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    ANALYSIS OF SACCHARIDE VACCINES WITHOUT INTERFERENCE
    4.
    发明申请
    ANALYSIS OF SACCHARIDE VACCINES WITHOUT INTERFERENCE 审中-公开
    没有干扰的沙门菌疫苗的分析

    公开(公告)号：US20120171241A1

    公开(公告)日：2012-07-05

    申请号：US13418211

    申请日：2012-03-12

    申请人： Angela Bardotti ,  Daniela Proietti ,  Stefano Ricci

    发明人： Angela Bardotti ,  Daniela Proietti ,  Stefano Ricci

    IPC分类号： A61K39/385 ,  A61P37/04 ,  G01N33/48

    CPC分类号： G01N33/56911 ,  A61K39/095 ,  A61K2039/6087 ,  G01N30/02 ,  G01N33/5308 ,  G01N2333/22 ,  G01N2400/10 ,  Y10T436/143333 ,  B01D15/363

    摘要： The invention is based on methods that allow analysis of mixed meningococcal saccharides from multiple serogroups even though they share monosaccharide units. With a combination of saccharides from serogroups C, W135 and Y, the invention analyses sialic acid, glucose and galactose content. The glucose and galactose results are used to directly quantify saccharides from serogroups Y and W135, respectively, and the combined glucose and galactose content is subtracted from the sialic acid content to quantify saccharides from serogroup C. The three serogroups can thus be resolved even though their monosaccharide contents overlap. The three different monosaccharide analyses can be performed on the same material, without interference between the monosaccharides and without interference from any other saccharide materials in the composition (e.g. lyophilisation stabilisers). The method can be used to analyse total and free saccharide in conjugate vaccines and simplifies quality control of vaccines containing capsular saccharides from multiple serogroups.

    摘要翻译： 本发明基于允许分析来自多个血清群的混合脑膜炎球菌糖的方法，即使它们共享单糖单元。 利用来自血清群C，W135和Y的糖的组合，本发明分析唾液酸，葡萄糖和半乳糖含量。 葡萄糖和半乳糖结果分别用于从血清组Y和W135直接定量糖，并从唾液酸含量中减去葡萄糖和半乳糖的含量，从血清群C中定量糖。因此，三个血清群可以被解决，即使它们 单糖含量重叠。 三种不同的单糖分析可以在相同的材料上进行，而不影响单糖之间的干扰，并且不受组合物中任何其他糖类物质（例如冻干稳定剂）的干扰。 该方法可用于分析结合疫苗中的总和游离糖，并简化了来自多个血清群的含有荚膜糖的疫苗的质量控制。

    Analysis of saccharide vaccines without interference
    5.
    发明授权
    Analysis of saccharide vaccines without interference 有权
    分析糖类疫苗无干扰

    公开(公告)号：US08137680B2

    公开(公告)日：2012-03-20

    申请号：US10593005

    申请日：2005-03-17

    申请人： Angela Bardotti ,  Daniela Proietti ,  Stefano Ricci

    发明人： Angela Bardotti ,  Daniela Proietti ,  Stefano Ricci

    IPC分类号： A61K39/095 ,  G01N31/00 ,  G01N31/02 ,  G01N21/00 ,  G01N30/02 ,  G01J3/42

    CPC分类号： G01N33/56911 ,  A61K39/095 ,  A61K2039/6087 ,  G01N30/02 ,  G01N33/5308 ,  G01N2333/22 ,  G01N2400/10 ,  Y10T436/143333 ,  B01D15/363

    摘要： The invention is based on methods that allow analysis of mixed meningococcal saccharides from multiple serogroups even though they share monosaccharide units. With a combination of saccharides from serogroups C, W135 and Y, the invention analyses sialic acid, glucose and galactose content. The glucose and galactose results are used to directly quantify saccharides from serogroups Y and W135, respectively, and the combined glucose and galactose content is subtracted from the sialic acid content to quantify saccharides from serogroup C. The three serogroups can thus be resolved even though their monosaccharide contents overlap. The three different monosaccharide analyses can be performed on the same material, without interference between the monosaccharides and without interference from any other saccharide materials in the composition (e.g. lyophilisation stabilisers). The method can be used to analyse total and free saccharide in conjugate vaccines and simplifies quality control of vaccines containing capsular saccharides from multiple serogroups.

    摘要翻译： 本发明基于允许分析来自多个血清群的混合脑膜炎球菌糖的方法，即使它们共享单糖单元。 利用来自血清群C，W135和Y的糖的组合，本发明分析唾液酸，葡萄糖和半乳糖含量。 葡萄糖和半乳糖结果分别用于从血清组Y和W135直接定量糖，并从唾液酸含量中减去葡萄糖和半乳糖的含量，从血清群C中定量糖。因此，三个血清群可以被解决，即使它们 单糖含量重叠。 三种不同的单糖分析可以在相同的材料上进行，而不影响单糖之间的干扰，并且不受组合物中任何其他糖类物质（例如冻干稳定剂）的干扰。 该方法可用于分析结合疫苗中的总和游离糖，并简化了来自多个血清群的含有荚膜糖的疫苗的质量控制。

    Analysis of Liquid Chromatography Eluates
    6.
    发明申请
    Analysis of Liquid Chromatography Eluates 有权
    液相色谱洗脱液分析

    公开(公告)号：US20080258710A1

    公开(公告)日：2008-10-23

    申请号：US11597254

    申请日：2005-05-20

    申请人： Daniela Proietti ,  Angela Bardotti ,  Stefano Ricci

    发明人： Daniela Proietti ,  Angela Bardotti ,  Stefano Ricci

    IPC分类号： G01R19/00 ,  G01J3/28

    CPC分类号： G01N30/78 ,  G01N27/44721 ,  G01N27/4473 ,  G01N30/02 ,  G01N30/64 ,  G01N30/74 ,  G01N2030/8809 ,  G01N2030/8836 ,  B01D15/363

    摘要： When analysing saccharides by HPAEC, the eluate from the column is typically analysed using a amperometric detector. According to the invention, amperometric detection is coupled with ultraviolet detection, with both methods being applied to the eluate. Thus the invention provides a method for analysing the eluate from a liquid chromatography column, wherein the eluate is analysed by both (a) amperometric detection and (b) ultraviolet detection. The information content derivable from using both sorts of detection advantageously exceeds that derivable from either of the two detection methods alone.

    摘要翻译： 当通过HPAEC分析糖时，通常使用电流检测器分析来自色谱柱的洗脱液。 根据本发明，电流检测与紫外检测结合，两种方法都应用于洗脱液。 因此，本发明提供了一种从液相色谱柱分析洗脱液的方法，其中通过（a）电流检测和（b）紫外检测来分析洗脱液。 从使用两种检测导出的信息内容有利地超过了仅从两种检测方法中的任一种得出的信息内容。