摘要:
The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein.
摘要:
The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein.
摘要:
Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
摘要:
Systems, methods, and apparatus are described that employ specially designed interference patterns to build an in-band side channel without degrading the effective throughput of the main channel. A first device (100) includes a control component (130) that generates control information and an interference component (140) that transmits the control information (450) through emission of patterned interference data concurrently while other users are transmitting other data (420). A second device (300) receives the patterned interference data and the other data via a single antenna (350) and decodes the patterned interference data to extract the control data (450). The first device (100) transmits the other data (420) on a side channel (440) that resides in the same spectrum as the main channel (410) in which the other data (420) is emitted. The first device (100) encodes the interference patterns such that the control data (450) can be safely transmitted and extracted without effecting other data transmission. In one aspect, devices (100, 200, 300) can employ a dynamic cooperation multi-access channel (DC-MAC) protocol (1510) to schedule transmission of the other data (420) on the main channel (410), and to employ the side channel (440) for control and coordination.
摘要:
Disclosed is a wireless speaker having a structure with the outer cover. The outer cover can be easily detached from the speaker body, facilitating user's mounting external electronic products as desired, for example, various types of bulbs, such as an LED or energy-saving lamp, and a wireless router or a camera. Also disclosed is a wireless speaker system, where the wireless set and the wireless speaker use wireless transmitting and receiving modules, or may use WiFi, Bluetooth or other wireless transmission modes. The wireless set supports a plurality of wireless speakers, and the wireless receiving speaker may be mounted on the ceiling, wall, or hidden place in a kitchen, living room, bedroom, bathroom or even bar, and restaurant; or even mounted on a table or floor lamp, or transportation means such as trains and planes, serving as a video and audio center for households and entertainment places by free combinations.
摘要:
A method and device for detaching a user equipment (UE) are disclosed in the present invention. The UE is registered with a mobility management entity (MME) in a packet switched (PS) network and a mobile switching center (MSC) in a circuit switched (CS) network. When the UE needs to detach from the PS network, the MSC receives a Detach Request with a Detach Type indicating the detaching from the PS network only; after receiving the Detach Request, the MSC deletes the context of the PS core network entity and clears the connection between the MSC and the MME. An MME for performing UE detachment is also disclosed in the present invention. The present invention helps reduce the time delay during the subsequent handover and quickly provide users with communications services, so as to improve user's experience and meet the carriers' requirements.
摘要:
Diagnostic methods for in vivo and ex vivo detection of circulating tumor cells (CTCs) for the diagnosis and treatment of cancer are provided. The diagnostic methods employ oncolytic viruses alone or in combination with one or more tumor cell enrichment and/or detection methods. Combinations and kits for use in the practicing the methods also are provided.
摘要:
A wireless illuminative speaker system, comprising a wireless transmitter comprising a transmitter body, a wireless transmit module, a main board printed board circuit assembly (PCBA), and a support, and at least one wireless illuminative receiving speaker comprising a speaker body, an illuminating part, a speaker part, and a wireless receiving module. The wireless transmitter operates to obtain audio data from an external electronic device and to transmit the audio data in the form of wireless audio digital signals, the wireless transmit module is disposed in the transmitter body, the main board PCBA operates to control the wireless transmit module, the support operates to mount an audio playing device thereon, the wireless illuminative receiving speaker operates to receive the wireless audio digital signals from the wireless transmitter and to plays the received wireless audio digital signals after digital-to-analog conversion, and the illuminating part is disposed in the speaker body.
摘要:
A method and device for detaching a user equipment (UE) are disclosed in the present invention. The UE is registered with a mobility management entity (MME) in a packet switched (PS) network and a mobile switching center (MSC) in a circuit switched (CS) network. When the UE needs to detach from the PS network, the MSC receives a Detach Request with a Detach Type indicating the detaching from the PS network only; after receiving the Detach Request, the MSC deletes the context of the PS core network entity and clears the connection between the MSC and the MME. An MME for performing UE detachment is also disclosed in the present invention. The present invention helps reduce the time delay during the subsequent handover and quickly provide users with communications services, so as to improve user's experience and meet the carriers' requirements.