公开(公告)号：US20110144001A1

公开(公告)日：2011-06-16

申请号：US12895106

申请日：2010-09-30

申请人： Mark BROENSTRUP ,  Hans GUEHRING ,  Holger HOFFMANN ,  Joachim WINK ,  Roderich SUESSMUTH ,  Timo SCHMIEDERER

发明人： Mark BROENSTRUP ,  Hans GUEHRING ,  Holger HOFFMANN ,  Joachim WINK ,  Roderich SUESSMUTH ,  Timo SCHMIEDERER

IPC分类号： A61K38/10 ,  C07K7/00 ,  A61P31/12 ,  A61P31/04 ,  C12N15/31 ,  A61P29/00

CPC分类号： C07K7/08 ,  C07K14/36

摘要： The invention refers to so-called Labyrinthopeptin derivatives of the formula (I) wherein {A}, {B}, {C}, R1-R6, m and n are as defined herein, obtainable from microorganism strain Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, a pharmaceutical composition comprising it, prepro-Labyrinthopeptin, pro-Labyrinthopeptin, and DNA coding for prepro-Labyrinthopeptin and pro-Labyrinthopeptin.

摘要翻译： 本发明涉及可从微生物菌株放线菌（Actinomadura namibiensis）（DSM 6313）获得的所谓的式（I）的赖氨维内肽衍生物，其中{A}，{B}，{C}，R1-R6，m和n如本文所定义 ，其用于治疗细菌感染，病毒感染和/或疼痛的药物组合物，包含其的药物组合物，前体Labyrinthopeptin，前Labyrinthopeptin和编码前LabLinhopeptin和亲Labyrinthopeptin的DNA。

公开(公告)号：US20070065932A1

公开(公告)日：2007-03-22

申请号：US11555809

申请日：2006-11-02

申请人： Holger HOFFMANN ,  Sabine HAAG-RICHTER ,  Michael Kurz ,  Heiko Tietgen

发明人： Holger HOFFMANN ,  Sabine HAAG-RICHTER ,  Michael Kurz ,  Heiko Tietgen

IPC分类号： C12N1/20

CPC分类号： C12R1/01 ,  C07D223/12 ,  C12P17/10

摘要： The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611 (DSM 15898).

摘要翻译： 本发明涉及在发酵期间由微生物粘球菌ST200611（DSM15898）在治疗癌症疾病中用于治疗癌症疾病的孟加拉酰胺衍生物，涉及制备式（b）的班格酰胺的方法， V）和微生物粘液菌（Myxococcus virescens）ST200611（DSM 15898）。

公开(公告)号：US20070065929A1

公开(公告)日：2007-03-22

申请号：US11555804

申请日：2006-11-02

申请人： Holger HOFFMANN ,  Sabine HAAG-RICHTER ,  Michael KURZ ,  Heiko TIETGEN

发明人： Holger HOFFMANN ,  Sabine HAAG-RICHTER ,  Michael KURZ ,  Heiko TIETGEN

IPC分类号： C12P17/00

CPC分类号： C12R1/01 ,  C07D223/12 ,  C12P17/10

摘要： The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611 (DSM 15898).

公开(公告)号：US20100256049A1

公开(公告)日：2010-10-07

申请号：US12640273

申请日：2009-12-17

申请人： Holger HOFFMANN ,  Christine KLEMKE-JAHN ,  Dietmar SCHUMMER ,  Herbert KOGLER

发明人： Holger HOFFMANN ,  Christine KLEMKE-JAHN ,  Dietmar SCHUMMER ,  Herbert KOGLER

IPC分类号： A61K38/12 ,  C07K5/12 ,  A61P31/10 ,  C12P21/04 ,  C12N1/00

CPC分类号： C07D273/00 ,  C07K5/0808 ,  C12P17/00 ,  C12R1/01

摘要： The disclosure relates to compounds of the formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, or a pharmaceutically acceptable salt thereof; which is formed by the microorganism ST 201196 (DSM 18870); the use thereof for the treatment and/or prophylaxis of fungal disorders; medicaments containing a compound of formula (I); processes for production thereof; and the microorganism ST 201196 (DSM 18870).

摘要翻译： 本公开涉及式（I）的化合物：其中R 1，R 2，R 3和R 4如本公开内容所定义，或其药学上可接受的盐; 其由微生物ST 201196（DSM 18870）形成; 其用于治疗和/或预防真菌病症的用途; 含有式（I）化合物的药物; 生产过程; 和微生物ST 201196（DSM 18870）。