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1.FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 审中-公开
标题翻译: 融合的杂环化合物化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US20080214643A1
公开(公告)日:2008-09-04
申请号:US12034690
申请日:2008-02-21
申请人: Mark E. Salvati , James Aaron Balog , Toomas Mitt
发明人: Mark E. Salvati , James Aaron Balog , Toomas Mitt
IPC分类号: A61K31/407
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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2.Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
标题翻译: 稠合的杂环琥珀酰亚胺化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US07655689B2
公开(公告)日:2010-02-02
申请号:US11338587
申请日:2006-03-20
申请人: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
发明人: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC分类号: C07D209/00 , A01N43/38
CPC分类号: C07D487/18
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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3.Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效
标题翻译: 稠合的杂环琥珀酰亚胺化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US07517904B2
公开(公告)日:2009-04-14
申请号:US11176810
申请日:2005-07-07
申请人: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
发明人: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC分类号: A61K31/407 , A61K31/34 , C07D491/08
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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公开(公告)号:US07141578B2
公开(公告)日:2006-11-28
申请号:US10974049
申请日:2004-10-25
申请人: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
发明人: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC分类号: A61K31/44 , A61K31/40 , C07D491/00 , C07D487/00
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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5.Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof 失效
标题翻译: 稠合杂环琥珀酰亚胺化合物及其类似物的制备方法公开(公告)号:US06953679B2
公开(公告)日:2005-10-11
申请号:US10024878
申请日:2001-12-19
申请人: Mark E. Salvati , Toomas Mitt , Ramesh N. Patel , Ronald L. Hanson , David Brzozowski , Animesh Goswami , Linda Nga Hoong Chu , Wen-sen Li , James H. Simpson , Michael J. Totleben , Weixuan He
发明人: Mark E. Salvati , Toomas Mitt , Ramesh N. Patel , Ronald L. Hanson , David Brzozowski , Animesh Goswami , Linda Nga Hoong Chu , Wen-sen Li , James H. Simpson , Michael J. Totleben , Weixuan He
IPC分类号: A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C12P17/10 , C12N1/00
CPC分类号: C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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公开(公告)号:US20060223832A1
公开(公告)日:2006-10-05
申请号:US10917031
申请日:2004-08-12
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/497 , C07D487/14
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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7.Fused Heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效
标题翻译: 融合的杂环琥珀酰亚胺化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US20050272799A1
公开(公告)日:2005-12-08
申请号:US11176810
申请日:2005-07-07
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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8.Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
标题翻译: 稠合的杂环琥珀酰亚胺化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US20050192253A1
公开(公告)日:2005-09-01
申请号:US10974049
申请日:2004-10-25
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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9.
公开(公告)号:US5608064A
公开(公告)日:1997-03-04
申请号:US457183
申请日:1995-06-01
申请人: Janak Singh , Gregory S. Bisacchi , Jollie D. Godfrey, Jr. , Toomas Mitt , Richard H. Mueller , Robert Zahler , Thomas P. Kissick
发明人: Janak Singh , Gregory S. Bisacchi , Jollie D. Godfrey, Jr. , Toomas Mitt , Richard H. Mueller , Robert Zahler , Thomas P. Kissick
IPC分类号: A61K31/52 , A61P31/12 , C07C211/63 , C07D473/00 , C07D473/32 , C07D473/40 , C07D473/18
CPC分类号: C07D473/00 , C07D473/40
摘要: A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl.
摘要翻译: 其中Y 1是氯,溴或碘,并且R 1,R 2,R 3和R 4独立地选自烷基和取代的烷基。
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10.
公开(公告)号:US06617323B2
公开(公告)日:2003-09-09
申请号:US10155274
申请日:2002-05-23
IPC分类号: A61K31535
CPC分类号: C07D413/12 , C07D263/32
摘要: The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I), wherein X is —C(O)—, —C(S)—, or —S(O)2—; A is an optionally-substituted saturated or unsaturated monocyclic or bicyclic ring; B is a saturated or unsaturated monocyclic or bicyclic ring system having at least one substituent Q which is selected from R7 and R8; R7 is selected from (C0-C6)alkyl, (C2-C6)alkenyl and (C2-C6)alkynyl and R7 is substituted with R8 is selected from (C0-C6)alkyl, (C2-C6)alkenyl and (C2-C6)alkynyl and R8 is substituted with and Z1 through Z5 are as defined in the specification.
摘要翻译: 本发明公开了可用于治疗或预防具有式(I)的IMPDH相关疾病如移植排斥反应和自身免疫性疾病的化合物,其中X是-C(O) - , - C(S) - 或-S (O)2 - ; A是任选取代的饱和或不饱和单环或双环; B是具有至少一个选自R7和R8的取代基Q的饱和或不饱和单环或双环体系; R 7选自(C 0 -C 6)烷基,(C 2 -C 6)烯基和(C 2 -C 6)炔基,R 7被R 8取代为(C 0 -C 6)烷基,(C 2 -C 6)烯基和(C 2 -C 6 )炔基和R8被Z取代,Z 1至Z 5如说明书中所定义。
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