公开(公告)号：US06458618B1

公开(公告)日：2002-10-01

申请号：US09697212

申请日：2000-10-26

申请人： Mark G. Allen ,  Sung-Pil Chang ,  Jeong-Bong Lee

发明人： Mark G. Allen ,  Sung-Pil Chang ,  Jeong-Bong Lee

IPC分类号： H01L2100

CPC分类号： G01L9/0073

摘要： The use of robust substrates on the surface micro-machined structures combines (1) the use of micro-machining technology; (2) the use of electronic packaging technologies; and (3) the use of conventional machining techniques to create a new class of micro-machined structures. A particular robust substrate-based micro-machine structure is a capacitive pressure sensor that includes a pressure sensitive diaphragm and an electrode.

摘要翻译： 在表面微加工结构上使用坚固的基材结合（1）使用微加工技术; （2）使用电子封装技术; 和（3）使用常规的加工技术来创建一类新的微加工结构。 特别坚固的基于基板的微机结构是包括压敏膜和电极的电容式压力传感器。

公开(公告)号：US09290756B2

公开(公告)日：2016-03-22

申请号：US12615778

申请日：2009-11-10

申请人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

发明人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

IPC分类号： G01N33/487 ,  C12N13/00 ,  C12M1/42 ,  G01N33/483

CPC分类号： C12N13/00 ,  B32B2535/00 ,  C12M1/42 ,  G01N33/4836 ,  G01N33/48728 ,  G01N33/48735 ,  Y10T156/10

摘要： Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.

摘要翻译： 本文提供了与开发用于高通量网络电生理学和细胞分析的仪器相关的装置和方法。 更具体地，本文提供了多孔微电极阵列（MEA）和用于以便宜的方式开发这种装置的方法，其具有柔性的符合ANSI / SBS（美国国家标准协会/生物分子筛选学会）的格式。 微电极阵列是用于刺激和感测电活性细胞，网络和组织的紧密间隔的微电极的网格。 本文所述的技术涉及使用微加工与已经用于实现符合ANSI / SBS的培养孔格式的多孔MEA的某些大面积方法的组合，其对于倒置/背面显微镜兼容性也是透明的。 这些多孔MEA可用于以高通量方式研究电活性细胞和组织如心脏，神经和肌肉的两维和三维网络。 同样符合ANSI / SBS标准，它们与制药行业开发用于药物筛选应用的机械和机器人兼容。

公开(公告)号：US20100019778A1

公开(公告)日：2010-01-28

申请号：US12506170

申请日：2009-07-20

申请人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

发明人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

IPC分类号： G01R27/28 ,  G05F1/10

CPC分类号： H02J50/00 ,  A61B5/0031 ,  A61B2560/0219 ,  G01K13/00 ,  G01L1/00 ,  G01L7/00 ,  H02J5/005 ,  H02J7/025

摘要： Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

摘要翻译： 无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。 一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。 电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。 转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。 此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

公开(公告)号：US07466120B2

公开(公告)日：2008-12-16

申请号：US11717967

申请日：2007-03-14

申请人： Donald J. Miller ,  Michael G. Ellis ,  Mark G. Allen

发明人： Donald J. Miller ,  Michael G. Ellis ,  Mark G. Allen

IPC分类号： G01R23/12 ,  G01R35/00

CPC分类号： A61B5/0031 ,  A61B5/02014 ,  A61B5/073 ,  A61B5/076 ,  A61B2560/0219

摘要： Aspects of the present invention determine the resonant frequency of a sensor by obtaining sensor signals in response to three energizing signals, measuring the phase of each sensor signal, and using a group phase delay to determine the resonant frequency. The phase difference between the first and second signal is determined as a first group phase delay. The phase difference between the second and third signal is determined as a second group phase delay. The first group phase delay and second group phase delay are compared. Based on the comparison, the system may lock on the resonant frequency of the sensor or adjust a subsequent set of three energizing signals.

摘要翻译： 本发明的方面通过响应于三个激励信号获得传感器信号，测量每个传感器信号的相位以及使用组相位延迟来确定谐振频率来确定传感器的谐振频率。 第一和第二信号之间的相位差被确定为第一组相位延迟。 第二和第三信号之间的相位差被确定为第二组相位延迟。 比较第一组相位延迟和第二组相位延迟。 基于比较，系统可以锁定传感器的谐振频率或调整后续的一组三个通电信号。

公开(公告)号：US07461882B2

公开(公告)日：2008-12-09

申请号：US11271450

申请日：2005-11-11

申请人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

发明人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

IPC分类号： B25J15/12 ,  B25J7/00

CPC分类号： C25D1/00 ,  B25J7/00 ,  B81C99/002 ,  Y10S294/902

摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.

摘要翻译： 公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。 微型工具包括具有柔性臂的镊子和致动机构。 通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。 致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。 在某些实施方案中，致动器运动由系留电缆远程控制。 还公开了一种用于生产微型工具，特别是通过微图案化的方法。 可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。 在某些实施方案中，镊子和致动机构被完全组装。 在其他实施方式中，镊子和致动机构分开制造并组装在一起。

公开(公告)号：US20080284187A1

公开(公告)日：2008-11-20

申请号：US11851579

申请日：2007-09-07

申请人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

发明人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

IPC分类号： B66C1/00

CPC分类号： C25D1/00 ,  B25J7/00 ,  B81C99/002 ,  Y10S294/902

摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.

摘要翻译： 公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。 微型工具包括具有柔性臂的镊子和致动机构。 通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。 致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。 在某些实施方案中，致动器运动由系留电缆远程控制。 还公开了一种用于生产微型工具，特别是通过微图案化的方法。 可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。 在某些实施方案中，镊子和致动机构被完全组装。 在其他实施方式中，镊子和致动机构分开制造并组装在一起。

公开(公告)号：US07115437B2

公开(公告)日：2006-10-03

申请号：US10935947

申请日：2004-09-08

申请人： Mark G. Allen ,  Charles C. Chung

发明人： Mark G. Allen ,  Charles C. Chung

IPC分类号： H01L21/00

CPC分类号： H01L21/761 ,  B81B3/0086 ,  B81B2201/033 ,  Y10S257/93

摘要： A micromachined structure having electrically isolated components is formed by thermomigrating a dopant through a substrate to form a doped region within the substrate. The doped region separates two portions of the substrate. The dopant is selected such that the doped region electrically isolates the two portions of the substrate from each other via junction isolation.

公开(公告)号：US07088567B2

公开(公告)日：2006-08-08

申请号：US10493131

申请日：2002-10-18

申请人： Andrew T. Hunt ,  Mark G. Allen

发明人： Andrew T. Hunt ,  Mark G. Allen

IPC分类号： H01G5/00

CPC分类号： H01G5/0132 ,  H01G7/00 ,  H01G7/04

摘要： Capacitors (10,20,40,50,70,80) having a fluid dielectric material that is transported or undergoes a phase change are disclosed. The dielectric medium change results in a change in the total dielectric constant of the material between the electrodes (12, 14, 72, 74, 81, 82), thus changing the capacitance of the capacitors. Transporting or phase changing the dielectric fluids into and out of a the electric field of the capacitor, changes the effective dielectric constant and the capacitance of the capacitor.

摘要翻译： 公开了具有运输或经历相变的流体介电材料的电容器（10,20,40,50,70,80）。 电介质变化导致电极（12,14,72,74,81,82）之间的材料的总介电常数的变化，从而改变电容器的电容。 将电介质流体输送或相位改变为电容器的电场，从而改变电容器的有效介电常数和电容。

公开(公告)号：US5655665A

公开(公告)日：1997-08-12

申请号：US353136

申请日：1994-12-09

申请人： Mark G. Allen ,  Chong-Hyuk Ahn

发明人： Mark G. Allen ,  Chong-Hyuk Ahn

IPC分类号： B03C1/035 ,  B03C1/00

CPC分类号： B03C1/035

摘要： A fully integrated micromachined magnetic particle manipulator and separator which can be used to influence magnetic particles suspended in a fluid. The magnetic particle manipulator and separator is integrated on a substrate, preferably a silicon wafer. The magnetic particle manipulator and separator is comprised of a fluid flow channel and integrated inductive components formed on each side of the channel. Each inductive component is comprised of a magnetic core and a conductor coil. Preferably, a meander-type inductor is used. The magnetic cores have ends located adjacent the fluid channel which function as electromagnet poles. When approximately 500 mA of DC current at less than 1 volt is supplied to the circuit, the inductive components produce magnetic fields and the magnetic particles suspended in the fluid clump onto the electromagnet poles. When the current is removed, the magnetic particles are released from the electromagnet poles.

摘要翻译： 一种完全集成的微加工磁性颗粒机械手和分离器，可用于影响悬浮在流体中的磁性颗粒。 磁性粒子机械手和分离器集成在基底上，优选硅晶片。 磁性颗粒机械手和分离器由流体流动通道和形成在通道的每一侧上的集成感应部件组成。 每个感应元件由磁芯和导体线圈构成。 优选地，使用曲折型电感器。 磁芯具有位于作为电磁铁极的流体通道附近的端部。 当小于1伏的大约500mA的DC电流被提供给电路时，感应元件产生磁场，悬浮在流体中的磁性颗粒聚集到电磁铁极上。 当电流被去除时，磁性颗粒从电磁铁极释放。

公开(公告)号：US5249954A

公开(公告)日：1993-10-05

申请号：US909911

申请日：1992-07-07

申请人： Mark G. Allen ,  Charles T. Butler ,  Stephen A. Johnson ,  Edmund Y. Lo ,  Farla M. Russo

发明人： Mark G. Allen ,  Charles T. Butler ,  Stephen A. Johnson ,  Edmund Y. Lo ,  Farla M. Russo

IPC分类号： F23N5/08 ,  F23H5/26

CPC分类号： F23N5/082 ,  F23N2023/52 ,  F23N2029/20

摘要： Disclosed is an integrated imaging sensor/neural network controller for combustion control systems. The controller uses electronic imaging sensing of chemiluminescence from a combustion system, combined with neural network image processing, to sensitively identify and control a complex combustion system. The imaging system used is not adversely affected by the normal emissions variations caused by changes in burner load and flame position. By incorporating neural networks to learn emission patterns associated with combustor performance, control using image technology is fast enough to be used in a real time, closed loop control system. This advance in sensing and control strategy allows use of the spatial distribution of important parameters in the combustion system in identifying the overall operation condition of a given combustor and in formulating a control response accorded to a pre-determined control model.

摘要翻译： 公开了一种用于燃烧控制系统的集成成像传感器/神经网络控制器。 控制器利用来自燃烧系统的化学发光的电子成像感测，结合神经网络图像处理，灵敏地识别和控制复杂的燃烧系统。 使用的成像系统不会受到燃烧器负载和火焰位置变化引起的正常排放变化的不利影响。 通过结合神经网络来学习与燃烧室性能相关的排放模式，使用图像技术的控制足够快以便在实时闭环控制系统中使用。 在传感和控制策略方面的进步允许在燃烧系统中使用重要参数的空间分布来识别给定燃烧器的总体运行状况，并根据预定的控制模型制定控制响应。