公开(公告)号：US09041416B2

公开(公告)日：2015-05-26

申请号：US13588518

申请日：2012-08-17

申请人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

发明人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

IPC分类号： A61B19/00 ,  A61B5/00 ,  H02J7/02

CPC分类号： H02J50/00 ,  A61B5/0031 ,  A61B2560/0219 ,  G01K13/00 ,  G01L1/00 ,  G01L7/00 ,  H02J5/005 ,  H02J7/025

摘要： Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

摘要翻译： 无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。 一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。 电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。 转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。 此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

公开(公告)号：US08264240B2

公开(公告)日：2012-09-11

申请号：US12506170

申请日：2009-07-20

申请人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

发明人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

IPC分类号： G01R27/28

CPC分类号： H02J50/00 ,  A61B5/0031 ,  A61B2560/0219 ,  G01K13/00 ,  G01L1/00 ,  G01L7/00 ,  H02J5/005 ,  H02J7/025

摘要： Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

摘要翻译： 无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。 一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。 电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。 转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。 此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

公开(公告)号：US20100019778A1

公开(公告)日：2010-01-28

申请号：US12506170

申请日：2009-07-20

申请人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

发明人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

IPC分类号： G01R27/28 ,  G05F1/10

CPC分类号： H02J50/00 ,  A61B5/0031 ,  A61B2560/0219 ,  G01K13/00 ,  G01L1/00 ,  G01L7/00 ,  H02J5/005 ,  H02J7/025

摘要： Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

摘要翻译： 无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。 一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。 电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。 转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。 此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

公开(公告)号：US20120313649A1

公开(公告)日：2012-12-13

申请号：US13588518

申请日：2012-08-17

申请人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

发明人： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

IPC分类号： G01R27/28

CPC分类号： H02J50/00 ,  A61B5/0031 ,  A61B2560/0219 ,  G01K13/00 ,  G01L1/00 ,  G01L7/00 ,  H02J5/005 ,  H02J7/025

摘要： Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

摘要翻译： 无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。 一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。 电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。 转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。 此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

公开(公告)号：US07196666B2

公开(公告)日：2007-03-27

申请号：US11145911

申请日：2005-06-06

申请人： Mark G. Allen ,  Yong-Kyu Yoon ,  Jin-Woo Park ,  Yeun-Ho Joung ,  Florent Cros ,  Ioannis Papapolymerou ,  Emmanouil Tentzeris ,  Bo Pan

发明人： Mark G. Allen ,  Yong-Kyu Yoon ,  Jin-Woo Park ,  Yeun-Ho Joung ,  Florent Cros ,  Ioannis Papapolymerou ,  Emmanouil Tentzeris ,  Bo Pan

IPC分类号： H01Q1/38

CPC分类号： H01Q19/32 ,  H01Q9/0407 ,  H01Q9/30

摘要： A surface micromachined electromagnetically radiating antenna includes a coplanar waveguide on a ground plane coated substrate having a conductor path. The conductor path is coupled to a monopole conductor, which has a generally-cylindrical backbone erected vertically from the substrate and a metal layer deposited on the backbone at a predetermined thickness. The antenna may be fabricated by depositing an epoxy on the ground plane coated substrate to a predetermined depth and according to a pattern. The epoxy is exposed to an ultraviolet source that develops one or more columns according to the pattern. A seed layer of metal may be formed on the developed column. A conductive metal is electrodeposited over the column surface to produce the monopole antenna. Other antenna may be created by adding monopoles and/or conductive metal patches and/or strips that are positioned atop the monopoles and elevated from the substrate.

摘要翻译： 表面微加工电磁辐射天线包括在具有导体路径的接地平面涂覆的基板上的共面波导。 导体路径耦合到单极导体，单极导体具有从衬底垂直竖立的通常为圆柱形的主体和以预定厚度沉积在骨架上的金属层。 天线可以通过在接地平面涂覆的基底上沉积环氧树脂至预定深度并根据图案来制造。 环氧树脂暴露于根据图案形成一个或多个柱的紫外线源。 可以在显影柱上形成金属种子层。 将导电金属电沉积在柱表面上以产生单极天线。 可以通过添加单极子和/或定位在单极子顶部并从衬底升高的导电金属贴片和/或条带来产生其它天线。

公开(公告)号：US06566251B2

公开(公告)日：2003-05-20

申请号：US09871200

申请日：2001-05-31

申请人： Mark G. Allen ,  Florent Cros ,  Jin-Woo Park ,  Kim Kieun

发明人： Mark G. Allen ,  Florent Cros ,  Jin-Woo Park ,  Kim Kieun

IPC分类号： H01L214763

CPC分类号： B81C99/009 ,  B81C2201/0188

摘要： Methods for creating one or more structures in a micromachined device. In one arrangement, the methods include the steps of providing a substrate, forming upstanding nonconductive mold walls on the substrate so that first and second wells are formed, the second well being wider than the first well. The method further includes applying a first material to the surface of the wells so that the first well fills with the first material before the second well, and removing the first material from the second well while leaving a portion in the first well.

公开(公告)号：US08690865B2

公开(公告)日：2014-04-08

申请号：US11597969

申请日：2005-05-31

申请人： Mark R. Prausnitz ,  Mark G. Allen ,  Jung-Hwan Park ,  Yong-Kyu Yoon ,  Jin-Woo Park

发明人： Mark R. Prausnitz ,  Mark G. Allen ,  Jung-Hwan Park ,  Yong-Kyu Yoon ,  Jin-Woo Park

IPC分类号： A61B18/08 ,  A61N1/30

CPC分类号： A61K9/0004 ,  A61B5/14514 ,  A61B18/082 ,  A61B18/10 ,  A61B2018/00005 ,  A61B2018/00613 ,  A61K9/7023 ,  A61K41/0047 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0046 ,  A61N1/0412 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/327

摘要： The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.

摘要翻译： 本发明包括用于热处理屏障以增加屏障的渗透性的方法和装置。 增加屏障渗透性的一种形式包括形成微孔，该微孔可用于通过阻挡层施用活性剂，或可用于取样或收集流体，或可用于检测，测量或确定分析物，或者可以是 用于监测生理或其他条件。 本发明的装置可以包括由电感或欧姆加热电源部件激活的微热电。

公开(公告)号：US09290756B2

公开(公告)日：2016-03-22

申请号：US12615778

申请日：2009-11-10

申请人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

发明人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

IPC分类号： G01N33/487 ,  C12N13/00 ,  C12M1/42 ,  G01N33/483

CPC分类号： C12N13/00 ,  B32B2535/00 ,  C12M1/42 ,  G01N33/4836 ,  G01N33/48728 ,  G01N33/48735 ,  Y10T156/10

摘要： Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.

摘要翻译： 本文提供了与开发用于高通量网络电生理学和细胞分析的仪器相关的装置和方法。 更具体地，本文提供了多孔微电极阵列（MEA）和用于以便宜的方式开发这种装置的方法，其具有柔性的符合ANSI / SBS（美国国家标准协会/生物分子筛选学会）的格式。 微电极阵列是用于刺激和感测电活性细胞，网络和组织的紧密间隔的微电极的网格。 本文所述的技术涉及使用微加工与已经用于实现符合ANSI / SBS的培养孔格式的多孔MEA的某些大面积方法的组合，其对于倒置/背面显微镜兼容性也是透明的。 这些多孔MEA可用于以高通量方式研究电活性细胞和组织如心脏，神经和肌肉的两维和三维网络。 同样符合ANSI / SBS标准，它们与制药行业开发用于药物筛选应用的机械和机器人兼容。

公开(公告)号：US07466120B2

公开(公告)日：2008-12-16

申请号：US11717967

申请日：2007-03-14

申请人： Donald J. Miller ,  Michael G. Ellis ,  Mark G. Allen

发明人： Donald J. Miller ,  Michael G. Ellis ,  Mark G. Allen

IPC分类号： G01R23/12 ,  G01R35/00

CPC分类号： A61B5/0031 ,  A61B5/02014 ,  A61B5/073 ,  A61B5/076 ,  A61B2560/0219

摘要： Aspects of the present invention determine the resonant frequency of a sensor by obtaining sensor signals in response to three energizing signals, measuring the phase of each sensor signal, and using a group phase delay to determine the resonant frequency. The phase difference between the first and second signal is determined as a first group phase delay. The phase difference between the second and third signal is determined as a second group phase delay. The first group phase delay and second group phase delay are compared. Based on the comparison, the system may lock on the resonant frequency of the sensor or adjust a subsequent set of three energizing signals.

摘要翻译： 本发明的方面通过响应于三个激励信号获得传感器信号，测量每个传感器信号的相位以及使用组相位延迟来确定谐振频率来确定传感器的谐振频率。 第一和第二信号之间的相位差被确定为第一组相位延迟。 第二和第三信号之间的相位差被确定为第二组相位延迟。 比较第一组相位延迟和第二组相位延迟。 基于比较，系统可以锁定传感器的谐振频率或调整后续的一组三个通电信号。

公开(公告)号：US07461882B2

公开(公告)日：2008-12-09

申请号：US11271450

申请日：2005-11-11

申请人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

发明人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

IPC分类号： B25J15/12 ,  B25J7/00

CPC分类号： C25D1/00 ,  B25J7/00 ,  B81C99/002 ,  Y10S294/902

摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.

摘要翻译： 公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。 微型工具包括具有柔性臂的镊子和致动机构。 通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。 致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。 在某些实施方案中，致动器运动由系留电缆远程控制。 还公开了一种用于生产微型工具，特别是通过微图案化的方法。 可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。 在某些实施方案中，镊子和致动机构被完全组装。 在其他实施方式中，镊子和致动机构分开制造并组装在一起。