Classification of Biological Samples Using Spectroscopic Analysis
    1.
    发明申请
    Classification of Biological Samples Using Spectroscopic Analysis 审中-公开
    使用光谱分析对生物样品进行分类

    公开(公告)号:US20120016818A1

    公开(公告)日:2012-01-19

    申请号:US13124208

    申请日:2009-10-30

    IPC分类号: G06F15/18 G06N5/04

    摘要: A method and system is described for rapidly classifying a sample of a biological fluid, comprising obtaining a spectrum of the biological fluid in response to excitation of the sample in a specified frequency range, and applying a multivariate classifier to one or more spectral regions of the spectrum to classify the biological sample into one class in a set of classes, the classes comprising at least two disease states having similar clinical symptoms. Methods and systems for developing the classifiers are also described. In one example the classification uses a vibrational spectrometer (5) to provide spectra from serum. The multivariate classifier may run on processor (9) to distinguish between disease states having similar clinical symptoms, such as malaria and cerebral malaria.

    摘要翻译: 描述了用于快速分类生物流体样品的方法和系统,包括响应于在特定频率范围内的样品的激发而获得生物流体的光谱,以及将多变量分类器应用于所述生物流体的一个或多个光谱区域 光谱将生物样品分成一组中的一类,该类包含至少两种具有相似临床症状的疾病状态。 还描述了用于开发分类器的方法和系统。 在一个示例中,分类使用振动光谱仪(5)来提供来自血清的光谱。 多变量分类器可以在处理器(9)上运行以区分具有类似临床症状的疾病状态,例如疟疾和脑疟疾。

    Method for specifically marking a protein
    3.
    发明授权
    Method for specifically marking a protein 有权
    专门标记蛋白质的方法

    公开(公告)号:US6156529A

    公开(公告)日:2000-12-05

    申请号:US367861

    申请日:1999-09-02

    CPC分类号: G01N33/6803 Y10S435/968

    摘要: The present invention relates to a method for the specific labeling of a protein containing selenocyst(e)ine and/or cyst(e)ine groups, comprising the following steps:at least one incubation of a protein-containing sample with at least one modifying agent specific for selenocyst(e)ine and/or cyst(e)ine groups, followed byat least one further incubation of said protein-containing sample with at least one labeling agent specific for selenocyst(e)ine and/or cyst(e)ine groups;wherein at least one substance interacting with said protein is added prior to and/or during and/or after at least one of said incubations.

    摘要翻译: PCT No.PCT / EP98 / 01229 Sec。 371 1999年9月2日第 102(e)1999年9月2日PCT 1998年3月5日PCT PCT。 公开号WO98 / 39660 日期:1998年9月11日本发明涉及含有硒蛋白(e)和/或囊肿(e)组的蛋白质的特异性标记方法,包括以下步骤:至少培养含蛋白质的样品 其中至少一种对硒代囊泡(e)和/或囊肿(e)组具有特异性的修饰剂,然后至少一次将所述含蛋白质样品与至少一种针对硒代囊泡(e)的特异性标记试剂和 /或囊肿(e)组; 其中与所述蛋白质相互作用的至少一种物质在所述孵育中的至少一种之前和/或之中和/或之后加入。