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公开(公告)号:US08372608B2
公开(公告)日:2013-02-12
申请号:US13053404
申请日:2011-03-22
申请人: Mark J. Burk , Grace DeSantis , Brian Morgan , Zuolin Zhu
发明人: Mark J. Burk , Grace DeSantis , Brian Morgan , Zuolin Zhu
CPC分类号: C12P13/004 , C07C253/14 , C07C253/30 , C12P13/002 , C12P13/02 , C12P17/10 , C07C255/16
摘要: The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.
摘要翻译: 本发明提供了制备4-氰基-3-羟基丁酸乙酯的新方法,例如(R)-4-氰基-3-羟基丁酸乙酯和4-氰基-3-羟基丁酸。 本发明提供了通过全细胞过程,细胞裂解物过程,一锅法和多锅法使用各种参数制备4-氰基-3-羟基丁酸和4-氰基-3-羟基丁酸乙酯的方案。
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公开(公告)号:US07932064B2
公开(公告)日:2011-04-26
申请号:US10461925
申请日:2003-06-13
申请人: Mark J. Burk , Grace Desantis , Brian Morgan , Zoulin Zhu
发明人: Mark J. Burk , Grace Desantis , Brian Morgan , Zoulin Zhu
CPC分类号: C12P13/004 , C07C253/14 , C07C253/30 , C12P13/002 , C12P13/02 , C12P17/10 , C07C255/16
摘要: The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.
摘要翻译: 本发明提供了制备乙基-4-氰基-3-羟基丁酸酯的新方法,例如(R)-4-氰基-3-羟基丁酸乙酯和4-氰基-3-羟基丁酸。 本发明提供了通过全细胞过程制备和4-氰基-3-羟基丁酸和4-氰基-3-羟基丁酸乙酯的方案,细胞裂解物方法,“一锅法”和“多锅”方法,使用各种 参数。
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公开(公告)号:US20110059493A1
公开(公告)日:2011-03-10
申请号:US12763198
申请日:2010-04-19
申请人: Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
发明人: Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
摘要: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译: 本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。 在一个方面,酶如水解酶,例如酯酶,用于本发明的方法中。
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公开(公告)号:US20080182303A1
公开(公告)日:2008-07-31
申请号:US10576122
申请日:2004-10-20
申请人: Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zillin Huang , William Greenberg
发明人: Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zillin Huang , William Greenberg
CPC分类号: C12P17/06 , C07D309/30
摘要: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译: 本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。 在一个方面,酶如水解酶,例如酯酶,用于本发明的方法中。
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公开(公告)号:US07700329B2
公开(公告)日:2010-04-20
申请号:US10576122
申请日:2004-10-20
申请人: Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
发明人: Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
CPC分类号: C12P17/06 , C07D309/30
摘要: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译: 本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。 在一个方面,酶如水解酶,例如酯酶,用于本发明的方法中。
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公开(公告)号:US06443598B1
公开(公告)日:2002-09-03
申请号:US09550323
申请日:2000-04-14
申请人: Brian Morgan
发明人: Brian Morgan
IPC分类号: F21V704
CPC分类号: F21V11/02
摘要: An overhead lighting appliance having a longitudinally extending and horizontally disposed lamp tube (4) housed within a reflector assembly of opposed downwardly diverging side reflectors (6) and cross blades (10) which divide the reflector assembly into cells and determine cut-off angles thus to reduce glare. Each cross blade (10) has an outer region (10a) to prevent ladder flash, which is of reduced or tapering thickness outwardly of a line C being a plane extending from the bottom of the reflector assembly to a tangent to an upper region of the lamp tube (4). The reduced width portion (10a) thus minimises obstruction of light output in the upper outer edge region of the cross blade.
摘要翻译: 一种架空照明器具,其具有纵向延伸且水平布置的灯管(4),其容纳在反射器组件内,该反射器组件包括相对的向下发散侧面反射器(6)和横向叶片(10),该反射器将反射器组件分成单元并确定截止角度 以减少眩光。 每个十字叶片(10)具有外部区域(10a),以防止梯子闪光,其从线C的外侧减小或渐缩的厚度是从反射器组件的底部延伸到与反射器组件的上部区域相切的平面 灯管(4)。 因此,减小的宽度部分(10a)使得在十字叶片的上外边缘区域中的光输出的阻碍最小化。
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公开(公告)号:US4067892A
公开(公告)日:1978-01-10
申请号:US647727
申请日:1976-01-09
IPC分类号: C07C43/205 , C07D317/24 , C11C3/02 , C09F5/08
CPC分类号: C07C205/35 , C07C43/205 , C07C45/298 , C07C45/71 , C07C47/575 , C07C49/84 , C07D317/24 , Y10S514/866 , Y10S514/884
摘要: Pharmaceutical compositions having hypolipidaemic and/or hypoglycaemic activity, contain a substituted (4-carboxyphenoxy) phenyl alkane derivative.
摘要翻译: 具有降血脂和/或低血糖活性的药物组合物含有取代的(4-羧基苯氧基)苯基烷烃衍生物。
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公开(公告)号:US20070204216A1
公开(公告)日:2007-08-30
申请号:US11361106
申请日:2006-02-24
申请人: Brian Morgan
发明人: Brian Morgan
IPC分类号: G06F15/00
CPC分类号: G06F17/212
摘要: A system, method, and program product are provided that receives a plurality of layout configuration selections from a user editing a layout configuration is provided. The layout configuration includes layout locations and each of the layout locations includes components, and each of the components includes attributes. The system, method, and program product receives attribute selections and trigger values from the user. The layout configuration, including the attribute selections and the trigger values, are stored in a nonvolatile storage area along with other layout configurations. When a request is received, the triggers stored in the nonvolatile storage area are compared to the request and one of the layout configurations is selected based on the comparison.
摘要翻译: 提供了一种系统,方法和程序产品,其从用户编辑提供的布局配置接收多个布局配置选择。 布局配置包括布局位置,每个布局位置包括组件,并且每个组件包括属性。 系统,方法和程序产品从用户接收属性选择和触发值。 包括属性选择和触发值的布局配置与其他布局配置一起存储在非易失性存储区域中。 当接收到请求时,将存储在非易失性存储区域中的触发与请求进行比较,并且基于比较来选择布局配置之一。
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公开(公告)号:US20070102575A1
公开(公告)日:2007-05-10
申请号:US11595525
申请日:2006-11-09
申请人: Brian Morgan , David Hagen
发明人: Brian Morgan , David Hagen
IPC分类号: B64C9/06
摘要: An aircraft attitude control configuration enables control surfaces to provide attitude control for an aircraft at hover or low air speed conditions. The aircraft attitude control configuration includes a thruster mounted to an aircraft for thrusting air, a first control surface kinematically coupled to the aircraft at a position downstream of the thruster, and a second control surface kinematically coupled to the aircraft at a position downstream of the thruster, the second control surface being differentially movable with respect to the first control surface such that a portion of the thrusted air from the thruster generates a first vector force on the first control surface and another portion of the thrusted air generates a second vector force on the second control surface, so that the first and the second vector forces provide a net roll moment about the Y-Roll axis.
摘要翻译: 飞机姿态控制配置使得控制面能够在悬停或低空气速度条件下为飞行器提供姿态控制。 飞行器姿态控制构型包括安装在飞行器上用于推动空气的推进器,在推进器下游的位置运动地联接到飞行器的第一控制表面,以及在推进器下游的位置运动地联接到飞行器的第二控制表面 所述第二控制表面可相对于所述第一控制表面差异移动,使得来自所述推进器的所述推动空气的一部分在所述第一控制表面上产生第一向量力,并且所述推动空气的另一部分在所述第二控制表面上产生第二向量力 第二控制表面,使得第一和第二向量力围绕Y-辊轴提供净滚动力矩。
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公开(公告)号:US09299223B2
公开(公告)日:2016-03-29
申请号:US13109510
申请日:2011-05-17
申请人: Andrew C. Guinn , Brian Morgan , James Palermo
发明人: Andrew C. Guinn , Brian Morgan , James Palermo
CPC分类号: G07F17/34 , G07F17/32 , G07F17/3258 , G07F17/329
摘要: A wagering game system and its operations are described herein. In some embodiments, the operations can include providing gaming content for use during a bingo game, where the gaming content includes a representation of a bingo game card that includes card identifiers, arranged in a distinct pattern, which are usable during the bingo game to track game identifiers, with equivalent values, when drawn during the bingo game. The operations can further include selecting a card identifier, in response to user input, which indicates a user prediction that a corresponding game identifier, with an equivalent value, will be drawn during the bingo game. The operations can further include placing a bet for a secondary wagering game on the selecting of the card identifier, detecting a draw of the corresponding game identifier during the bingo game, and using the draw of the game identifier as an outcome for the bet.
摘要翻译: 本文描述了投注游戏系统及其操作。 在一些实施例中,操作可以包括提供在宾果游戏期间使用的游戏内容,其中游戏内容包括宾夕法尼亚游戏卡的表示,宾果游戏卡包括布置在不同模式中的卡标识符,其可以在宾果游戏期间使用以跟踪 游戏标识符,具有等效值,在宾果游戏中绘制时。 操作可以进一步包括响应于用户输入选择卡标识符,其指示用户预测在宾果游戏期间将绘制具有等效值的相应游戏标识符。 该操作可以进一步包括在选择卡标识符时检测第二投注游戏的赌注,在宾果游戏期间检测相应的游戏标识符的绘制,以及使用游戏标识符的绘制作为投注的结果。
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