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公开(公告)号：US07875293B2
公开(公告)日：2011-01-25
申请号：US10842716
申请日：2004-05-10
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译： 一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。 可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。
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公开(公告)号：US20060204536A1
公开(公告)日：2006-09-14
申请号：US11416734
申请日：2006-05-03
IPC分类号： A61F13/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
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公开(公告)号：US20050031689A1
公开(公告)日：2005-02-10
申请号：US10842716
申请日：2004-05-10
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译： 一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。 可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。
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公开(公告)号：US20050033132A1
公开(公告)日：2005-02-10
申请号：US10846150
申请日：2004-05-14
申请人： Mark Shults , James Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic , Stuart Updike , Rathbun Rhodes
发明人： Mark Shults , James Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic , Stuart Updike , Rathbun Rhodes
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US20060198864A1
公开(公告)日：2006-09-07
申请号：US11416825
申请日：2006-05-03
IPC分类号： A61F13/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译： 一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。 可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。
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公开(公告)号：US20080228051A1
公开(公告)日：2008-09-18
申请号：US12037812
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/145
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
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公开(公告)号：US07860545B2
公开(公告)日：2010-12-28
申请号：US12037812
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/00
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US20080228054A1
公开(公告)日：2008-09-18
申请号：US12037830
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/05
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US08882741B2
公开(公告)日：2014-11-11
申请号：US13460219
申请日：2012-04-30
申请人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
发明人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译： 提供了用于集成包括接收器，药物输送装置和任选的单点葡萄糖监测器的连续葡萄糖传感器的系统和方法。 手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。 设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间 例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。 设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。
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公开(公告)号：US20120238852A1
公开(公告)日：2012-09-20
申请号：US13460365
申请日：2012-04-30
申请人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
发明人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
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