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公开(公告)号：US07860545B2
公开(公告)日：2010-12-28
申请号：US12037812
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/00
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US20080228051A1
公开(公告)日：2008-09-18
申请号：US12037812
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/145
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
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公开(公告)号：US20080228054A1
公开(公告)日：2008-09-18
申请号：US12037830
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/05
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US20100041971A1
公开(公告)日：2010-02-18
申请号：US12608872
申请日：2009-10-29
申请人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
发明人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
IPC分类号： A61B5/1468 , H01R43/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
摘要翻译： 包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域的可植入分析物传感器。 将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。 传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。
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公开(公告)号：US07901354B2
公开(公告)日：2011-03-08
申请号：US12113724
申请日：2008-05-01
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/14 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B2560/0223
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
摘要翻译： 本发明一般涉及用于测量宿主中分析物的系统和方法。 更具体地，本发明涉及用于经皮和皮下测量宿主中葡萄糖的系统和方法。
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公开(公告)号：US08509871B2
公开(公告)日：2013-08-13
申请号：US12260017
申请日：2008-10-28
IPC分类号： A61B5/05
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/006 , G01N33/48707 , G01N33/48785
摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
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公开(公告)号：US20090045055A1
公开(公告)日：2009-02-19
申请号：US12260017
申请日：2008-10-28
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/006 , G01N33/48707 , G01N33/48785
摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
摘要翻译： 本发明提供了一种用于可植入装置的传感器头，其用于测量生物流体中分析物的浓度，其包括：非导电体; 工作电极，参考电极和对电极，其中电极穿过非导电体，其在身体的一个位置处形成电化学反应性表面，并在身体的另一位置形成电子连接，其中电化学反应性 对电极的表面大于工作电极的表面积; 以及附着在非导体上并覆盖工作电极，参比电极和对电极的多区域膜。 此外，本发明提供一种可植入装置，其包括本发明的至少一个传感器头和利用本发明的可植入装置监测主机中的葡萄糖水平的方法。
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公开(公告)号：US07875293B2
公开(公告)日：2011-01-25
申请号：US10842716
申请日：2004-05-10
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译： 一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。 可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。
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公开(公告)号：US08255033B2
公开(公告)日：2012-08-28
申请号：US11410392
申请日：2006-04-25
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
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公开(公告)号：US08255030B2
公开(公告)日：2012-08-28
申请号：US11410555
申请日：2006-04-25
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
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