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    Optimized sensor geometry for an implantable glucose sensor
    8.
    发明授权
    Optimized sensor geometry for an implantable glucose sensor 有权
    优化的植入式葡萄糖传感器的传感器几何

    公开(公告)号：US07881763B2

    公开(公告)日：2011-02-01

    申请号：US11415631

    申请日：2006-05-02

    申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

    发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

    IPC分类号： A61B5/1473

    CPC分类号： A61B5/6882 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/415 ,  A61B5/418 ,  A61B2562/187

    摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

    摘要翻译： 一种用于测量体液中诸如葡萄糖的分析物的浓度的植入式传感器，其包括具有适于在所述传感器和所述体液之间输送分析物的感测区域的身体，其中所述感测区域位于弯曲部分上 使得当异物体胶囊围绕传感器形成时，异物胶囊朝向感测区域施加收缩力。 身体部分或完全弯曲，部分或完全覆盖有用于支撑组织向内生长的锚固材料，并被设计用于皮下组织植入。 几何设计，包括曲率，形状和其他因素最大限度地减少传感区域的慢性炎症反应，并有助于改善体内传感器的性能。

    Porous membranes for use with implantable devices
    9.
    发明申请
    Porous membranes for use with implantable devices 有权
    用于可植入装置的多孔膜

    公开(公告)号：US20100256779A1

    公开(公告)日：2010-10-07

    申请号：US11654135

    申请日：2007-01-17

    申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Mark A. Tapsak

    发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Mark A. Tapsak

    IPC分类号： A61F2/02 ,  A61B5/05

    CPC分类号： A61L31/146 ,  A61L31/10 ,  A61L31/14

    摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.

    摘要翻译： 用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是 对细胞和细胞过程不可渗透，并允许分析物通过。 该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。 膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。

    POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES
    10.
    发明申请
    POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES 审中-公开
    多孔膜与可植入的器件一起使用

    公开(公告)号：US20110313543A1

    公开(公告)日：2011-12-22

    申请号：US13210338

    申请日：2011-08-15

    申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Mark A. Tapsak

    发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Mark A. Tapsak

    IPC分类号： A61F2/02 ,  A61B5/00

    CPC分类号： A61L31/146 ,  A61L31/10 ,  A61L31/14

    摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.

    摘要翻译： 用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是 对细胞和细胞过程不可渗透，并允许分析物通过。 该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。 膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。