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公开(公告)号：US20120265084A1
公开(公告)日：2012-10-18
申请号：US13084853
申请日：2011-04-12
IPC分类号： A61B5/0402
CPC分类号： A61B5/743 , A61B5/01 , A61B5/0215 , A61B5/0402 , A61B5/0422 , A61B5/055 , A61B5/14542 , A61B5/6852 , A61B6/12 , A61B6/503 , A61B8/0841 , A61B8/0883
摘要： A method of mapping electrophysiological information, including receiving imaging information for a tissue region; receiving a monophasic action potential signal from the tissue region; assigning a value corresponding to a depolarization segment of the monophasic action potential signal; receiving location information associated with the monophasic action potential signal; and generating an image based on the imaging information, the assigned value, and the location information.
摘要翻译： 一种映射电生理信息的方法，包括接收组织区域的成像信息; 从所述组织区域接收单相动作电位信号; 分配与单相动作电位信号的去极化部分对应的值; 接收与单相动作电位信号相关联的位置信息; 以及基于成像信息，分配值和位置信息生成图像。
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公开(公告)号：US20130296840A1
公开(公告)日：2013-11-07
申请号：US13460900
申请日：2012-05-01
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B90/06 , A61B2018/0022 , A61B2018/00285 , A61B2018/00345 , A61B2018/00577 , A61B2018/00642 , A61B2018/00708 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/1467 , A61B2090/065
摘要： Systems and methods for assessing tissue contact, including positioning an electrode adjacent a tissue region; delivering radiofrequency energy to the electrode, wherein the delivered radiofrequency energy is sufficient to ablate at least a portion of the tissue region; obtaining a plurality of impedance measurements from the electrode during the delivery of the radiofrequency energy; calculating a change in the impedance measurements over a pre-determined time period; and generating an alert if the calculated change is less than a pre-defined value.
摘要翻译： 用于评估组织接触的系统和方法，包括将电极定位在组织区域附近; 向所述电极提供射频能量，其中所输送的射频能量足以消融所述组织区域的至少一部分; 在传送射频能量期间从电极获得多个阻抗测量值; 计算预定时间段内的阻抗测量值的变化; 并且如果所计算的改变小于预定义值则产生警报。
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公开(公告)号：US20130006082A1
公开(公告)日：2013-01-03
申请号：US13604139
申请日：2012-09-05
申请人： Michael LAU , Randell WERNETH , Timothy J. CORVI , Sumita BHOLA , Mark T. STEWART , Michel HAISSAGUERRE , Meleze HOCINI
发明人： Michael LAU , Randell WERNETH , Timothy J. CORVI , Sumita BHOLA , Mark T. STEWART , Michel HAISSAGUERRE , Meleze HOCINI
CPC分类号： A61B5/042 , A61B5/6858 , A61B18/1492 , A61B2018/00214 , A61B2018/00839 , A61B2018/00898 , A61N1/06
摘要： Catheters and methods for obtaining monophasic action potential (“MAP”) electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.
摘要翻译： 用于获得单相动作电位（MAP）电描记图的导管和方法包括限定纵向轴线的柔性导管主体，以及固定到导管主体远端的远端组件，其限定远端尖端。 远端组件具有至少三个MAP记录电极和用于确定参考电位的至少一个参考电极。 记录电极各自在至少三个不同的径向方向上与纵向轴线径向距离，限定基本上具有径向对称性的记录几何形状。 参考电极是与记录几何形状的纵向距离。 可选功能包括可导向的导管轴，一个或多个射频消融电极和专用起搏电极。 不同的可能实施例包括具有固定空间布置的记录电极的圆顶壳体和在至少三个柔性环形元件上具有电极阵列的远端环组件。
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4.发明申请MULTI FREQUENCY AND MULTI POLARITY COMPLEX IMPEDANCE MEASUREMENTS TO ASSESS ABLATION LESIONS 有权多频和多极性复合阻抗测量用于评估消除距离公开(公告)号：US20120197243A1
公开(公告)日：2012-08-02
申请号：US13017122
申请日：2011-01-31
CPC分类号： A61B18/1492 , A61B5/4848 , A61B18/02 , A61B18/12 , A61B2017/00128 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00279 , A61B2018/00285 , A61B2018/00404 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00666 , A61B2018/00869 , A61B2018/00875 , A61B2018/0212
摘要： A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.
摘要翻译： 一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 用所述医疗装置测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用所述医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。
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公开(公告)号：US20130030425A1
公开(公告)日：2013-01-31
申请号：US13194180
申请日：2011-07-29
申请人： Mark T. STEWART , Jordon D. HONECK
发明人： Mark T. STEWART , Jordon D. HONECK
CPC分类号： A61B18/1492 , A61B18/02 , A61B2018/0022 , A61B2018/00357 , A61B2018/00577 , A61B2018/00613 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00994 , A61B2018/0212 , A61B2018/0237 , A61B2018/0262 , A61B2018/1437
摘要： A medical system, including a catheter body, an elongate body disposed in the catheter body; an expandable element having a proximal portion coupled to the catheter body and a distal portion coupled to the elongate body, the distal portion of the expandable element defining the distal-most portion of the medical device; a mesh or array of longitudinal splines substantially surrounding the expandable element, at least a portion of the mesh or splines being electrically conductive; and a coolant source in fluid communication with the expandable element.
摘要翻译： 医疗系统，包括导管主体，设置在导管主体中的细长主体; 可扩张元件，其具有联接到导管主体的近端部分和联接到细长主体的远端部分，可扩张元件的远端部分限定医疗装置的最远部分; 基本上围绕所述可膨胀元件的纵向花键的网状物或阵列，所述网状物或花键的至少一部分是导电的; 以及与可膨胀元件流体连通的冷却剂源。
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公开(公告)号：US20120232374A1
公开(公告)日：2012-09-13
申请号：US13044698
申请日：2011-03-10
申请人： Randell L. WERNETH , Meleze HOCINI , Mark T. STEWART , Dan WITTENBERGER , Timothy J. CORVI , Michael LAU , Vinod SHARMA
发明人： Randell L. WERNETH , Meleze HOCINI , Mark T. STEWART , Dan WITTENBERGER , Timothy J. CORVI , Michael LAU , Vinod SHARMA
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.
摘要翻译： 一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。 控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。
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公开(公告)号：US20130296679A1
公开(公告)日：2013-11-07
申请号：US13460877
申请日：2012-05-01
IPC分类号： A61B5/02
CPC分类号： A61B18/1492 , A61B5/068 , A61B5/6856 , A61B5/6858 , A61B34/20 , A61B2018/00351 , A61B2018/00577 , A61B2018/00875 , A61B2018/1467
摘要： Systems and methods for assessing electrode position, including positioning a plurality of electrodes within a heart and proximate a pulmonary vein; obtaining an impedance measurement from each of the plurality of electrodes; determining whether any of the plurality of electrodes is located within the pulmonary vein based at least in part on the obtained impedance measurements; and generating an indication if at least one of the plurality of electrodes is determined to be located within the pulmonary vein.
摘要翻译： 用于评估电极位置的系统和方法，包括将多个电极定位在心脏内并且靠近肺静脉; 从所述多个电极中的每一个获得阻抗测量; 至少部分地基于获得的阻抗测量来确定多个电极中的任何一个是否位于肺静脉内; 以及如果所述多个电极中的至少一个被确定为位于所述肺静脉内，则产生指示。
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公开(公告)号：US20130296839A1
公开(公告)日：2013-11-07
申请号：US13460864
申请日：2012-05-01
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/00267 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00779 , A61B2018/00875 , A61B2018/00898
摘要： A method and system for detecting microbubble formation during a radiofrequency ablation procedure. The method includes measuring an impedance of a pair of electrodes, at least one electrode in the pair of electrodes being coupled to a treatment assembly of a medical device. Radiofrequency ablation energy is transmitted between the pair of electrodes. The transmission of radiofrequency ablation energy between the pair of electrodes is terminated when after a predetermined period of time the measured impedance in either of the electrodes in the pair of electrodes is a predetermined percentage above a measured minimum impedance and a measured power is above a predetermined power threshold. An alert is generated indicating at least one of the formation and release of microbubbles proximate the pair of electrodes.
摘要翻译： 一种用于在射频消融过程中检测微泡形成的方法和系统。 该方法包括测量一对电极的阻抗，该对电极中的至少一个电极耦合到医疗装置的治疗组件。 射频消融能量在一对电极之间传输。 在一对电极之间的射频消融能量的传输终止，在预定时间段之后，该对电极中的任一个电极中的测量阻抗比测量的最小阻抗高出预定百分比，并且测量的功率高于预定的时间 功率阈值。 产生警报，指示邻近该对电极的微泡的形成和释放中的至少一个。
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9.发明申请公开(公告)号：US20130030430A1
公开(公告)日：2013-01-31
申请号：US13194259
申请日：2011-07-29
申请人： Mark T. STEWART , Jordon D. HONECK
发明人： Mark T. STEWART , Jordon D. HONECK
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/1435 , A61N1/327
摘要： A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.
摘要翻译： 一种医疗系统，包括具有多个可展开臂的医疗装置，以及至少一个所述多个臂中的至少一个的至少一个电极; 以及电信号发生器，其与医疗装置通信，该电信号发生器被编程为将脉冲能量传送到医疗装置，足以引起不可逆的电穿孔消融。
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公开(公告)号：US20110028966A1
公开(公告)日：2011-02-03
申请号：US12533903
申请日：2009-07-31
CPC分类号： A61B5/042 , A61B5/6858 , A61B18/1492 , A61B2018/00214 , A61B2018/00839 , A61B2018/00898 , A61N1/06
摘要： Catheters and methods for obtaining monophasic action potential (“MAP”) electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.
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