公开(公告)号：US20080015447A1

公开(公告)日：2008-01-17

申请号：US11570669

申请日：2005-06-20

Applicant: Mark Towler ,  Declan Lyons

Inventor： Mark Towler ,  Declan Lyons

IPC: A61B18/20

CPC classification number: A61B5/0075 ,  A61B5/0059 ,  A61B5/441 ,  A61B5/4504 ,  A61B5/4509 ,  G01J3/44

Abstract: Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.

Abstract translation: 提供诊断骨质疏松症等骨疾病的方法。 所述方法包括检测角质化组织的物理或化学结构的变化作为疾病的相关性。 所述方法包括检测角化组织样品如指甲，毛发或皮肤中的硫键的硬度，模量或水平的变化，特别是二硫键的水平。 这些变量的变化用作与骨骼弹性和骨密度变化相关的骨骼疾病的诊断标记。

公开(公告)号：US11369633B2

公开(公告)日：2022-06-28

申请号：US15354289

申请日：2016-11-17

Applicant: Mark Towler

Inventor： Mark Towler

IPC: A61K33/42 ,  C03C3/097 ,  C03C4/00 ,  A61L26/00 ,  A61K33/30 ,  A61K33/24 ,  A61K33/08 ,  A61K33/00 ,  C03C11/00 ,  A61L15/18 ,  A61L15/46 ,  A61L15/28

Abstract: The present disclosure relates to mesoporous glasses as well as uses of such glasses, for example, as hemostats.

公开(公告)号：US20090012403A1

公开(公告)日：2009-01-08

申请号：US11994246

申请日：2006-06-29

Applicant: Keith Carron ,  Mark Towler

Inventor： Keith Carron ,  Mark Towler

IPC: A61B6/00 ,  G01N21/65

CPC classification number: G01N21/65 ,  A61B5/0059 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/7257 ,  A61B5/7275 ,  G06F19/00

Abstract: A method is disclosed for analyzing keratinized tissue, particularly fingernails, of a subject to diagnose osteoporosis and bone fracture risk. A Raman spectrum of a sample of keratinized tissue is generated. Broad spectral background features of the spectrum are removed, preferably by using Fourier transform analysis. Peak heights of Raman features of interest, particularly the S—S bond of cystine, are measured. These peak height measurements are normalized using reference peak heights of Raman features that are invariant between normal and osteoporotic subjects, such as the CH2 bending peak.

Abstract translation: 公开了用于分析受试者的角质化组织，特别是指甲的诊断骨质疏松症和骨折风险的方法。 产生角化组织样品的拉曼光谱。 优选通过使用傅立叶变换分析去除光谱的宽光谱背景特征。 测量了拉曼特征的峰值高度，特别是胱氨酸的S-S键。 使用在正常和骨质疏松受试者之间不变的拉曼特征的参考峰高度，例如CH2弯曲峰，使这些峰高度测量值被归一化。

公开(公告)号：US20180133251A1

公开(公告)日：2018-05-17

申请号：US15354289

申请日：2016-11-17

Applicant: Mark Towler

Inventor： Mark Towler

IPC: A61K33/42 ,  C03C3/097 ,  C03C4/00 ,  A61K33/30 ,  A61K33/24 ,  A61K33/08 ,  A61K33/00 ,  A61L26/00

CPC classification number: A61K33/42 ,  A61K33/00 ,  A61K33/08 ,  A61K33/24 ,  A61K33/30 ,  A61L15/18 ,  A61L15/28 ,  A61L15/46 ,  A61L26/0085 ,  A61L2300/10 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2400/04 ,  C03C3/097 ,  C03C4/0007 ,  C03C11/00 ,  C08L1/02

Abstract: The present disclosure relates to mesoporous glasses as well as uses of such glasses, for example, as hemostats

公开(公告)号：US07962199B2

公开(公告)日：2011-06-14

申请号：US11994246

申请日：2006-06-29

Applicant: Keith Carron ,  Mark Towler

Inventor： Keith Carron ,  Mark Towler

IPC: A61B5/05

CPC classification number: G01N21/65 ,  A61B5/0059 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/7257 ,  A61B5/7275 ,  G06F19/00

Abstract: A method is disclosed for analyzing keratinized tissue, particularly fingernails, of a subject to diagnose osteoporosis and bone fracture risk. A Raman spectrum of a sample of keratinized tissue is generated. Broad spectral background features of the spectrum are removed, preferably by using Fourier transform analysis. Peak heights of Raman features of interest, particularly the S—S bond of cystine, are measured. These peak height measurements are normalized using reference peak heights of Raman features that are invariant between normal and osteoporotic subjects, such as the CH2 bending peak.

Abstract translation: 公开了用于分析受试者的角质化组织，特别是指甲的诊断骨质疏松症和骨折风险的方法。 产生角化组织样品的拉曼光谱。 优选通过使用傅立叶变换分析去除光谱的宽光谱背景特征。 测量了拉曼特征的峰值高度，特别是胱氨酸的S-S键。 使用在正常和骨质疏松受试者之间不变的拉曼特征的参考峰高度，例如CH2弯曲峰，使这些峰高度测量值被归一化。

公开(公告)号：US20090099458A9

公开(公告)日：2009-04-16

申请号：US11570669

申请日：2005-06-20

Applicant: Mark Towler ,  Declan Lyons

Inventor： Mark Towler ,  Declan Lyons

IPC: A61B18/20

CPC classification number: A61B5/0075 ,  A61B5/0059 ,  A61B5/441 ,  A61B5/4504 ,  A61B5/4509 ,  G01J3/44

Abstract: Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.

Abstract translation: 提供诊断骨质疏松症等骨疾病的方法。 所述方法包括检测角质化组织的物理或化学结构的变化作为疾病的相关性。 所述方法包括检测角化组织样品如指甲，毛发或皮肤中的硫键的硬度，模量或水平的变化，特别是二硫键的水平。 这些变量的变化用作与骨骼弹性和骨密度变化相关的骨骼疾病的诊断标记。