公开(公告)号：US20090099458A9

公开(公告)日：2009-04-16

申请号：US11570669

申请日：2005-06-20

Applicant: Mark Towler ,  Declan Lyons

Inventor： Mark Towler ,  Declan Lyons

IPC: A61B18/20

CPC classification number: A61B5/0075 ,  A61B5/0059 ,  A61B5/441 ,  A61B5/4504 ,  A61B5/4509 ,  G01J3/44

Abstract: Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.

Abstract translation: 提供诊断骨质疏松症等骨疾病的方法。 所述方法包括检测角质化组织的物理或化学结构的变化作为疾病的相关性。 所述方法包括检测角化组织样品如指甲，毛发或皮肤中的硫键的硬度，模量或水平的变化，特别是二硫键的水平。 这些变量的变化用作与骨骼弹性和骨密度变化相关的骨骼疾病的诊断标记。

公开(公告)号：US20080015447A1

公开(公告)日：2008-01-17

申请号：US11570669

申请日：2005-06-20

Applicant: Mark Towler ,  Declan Lyons

Inventor： Mark Towler ,  Declan Lyons

IPC: A61B18/20

CPC classification number: A61B5/0075 ,  A61B5/0059 ,  A61B5/441 ,  A61B5/4504 ,  A61B5/4509 ,  G01J3/44

Abstract: Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.

Abstract translation: 提供诊断骨质疏松症等骨疾病的方法。 所述方法包括检测角质化组织的物理或化学结构的变化作为疾病的相关性。 所述方法包括检测角化组织样品如指甲，毛发或皮肤中的硫键的硬度，模量或水平的变化，特别是二硫键的水平。 这些变量的变化用作与骨骼弹性和骨密度变化相关的骨骼疾病的诊断标记。

公开(公告)号：US08535238B2

公开(公告)日：2013-09-17

申请号：US11570669

申请日：2005-06-20

Applicant: Mark Robert Towler ,  Declan Lyons

Inventor： Mark Robert Towler ,  Declan Lyons

IPC: A61B10/00

CPC classification number: A61B5/0075 ,  A61B5/0059 ,  A61B5/441 ,  A61B5/4504 ,  A61B5/4509 ,  G01J3/44

Abstract: Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.

公开(公告)号：US10124172B2

公开(公告)日：2018-11-13

申请号：US15193927

申请日：2016-06-27

Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY ,  Declan Lyons ,  Colin Quinn

Inventor： Declan Lyons ,  Colin Quinn ,  Gearóid Ó Laighin ,  Paul Breen ,  Brian Deegan ,  Fabio Quondamatteo

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/365 ,  A61B5/0245 ,  A61B5/0205 ,  A61B5/0402 ,  A61B5/0488 ,  A61B5/00 ,  A61N1/372 ,  A61N1/378 ,  A61N1/05 ,  A61B5/11 ,  A61B5/08 ,  A61B5/024

Abstract: A monitoring system has biomechanical sensors, physiological sensors and a controller which receive sensory inputs from the sensors to provide output signals for the output device, and it detects from the sensory inputs risk of a syncopal event The bio-mechanical sensors include sensors arranged to allow the processor to detect a user postures and posture transitions. The processor operates a finite state machine, in which there is a state corresponding to each of a plurality of user physical postures and to each of a plurality of transitions between said postures, and the processor determines a relevant state depending on the sensory inputs. A device output may be muscle stimulation to prevent syncope, and there are stimulation permissions associated with the finite state machine states.