摘要:
The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
摘要:
The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
摘要:
Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.
摘要:
Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.
摘要:
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要:
This disclosure provides systems, methods, and apparatus related to freeze casting. In one aspect, a method comprises providing an apparatus. The apparatus comprises a container and a cooling surface. A bottom of the container comprises a wedge. The wedge comprises a first substantially planar surface and a second substantially planar surface with an angle between the first and the second substantially planar surfaces. An interior bottom of the container comprises the second substantially planar surface. The cooling surface is in contact with the first substantially planar surface. A slurry is deposited on the second substantially planar surface, the slurry comprising a plurality of particles in a liquid. The cooling surface is cooled to cool the slurry at a specified cooling rate.
摘要:
The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要:
Apparatus, systems, and methods may operate to receive a real image or real images of a coverage area of a surveillance camera. Building Information Model (BIM) data associated with the coverage area may be received. A virtual image may be generated using the BIM data. The virtual image may include at least one three-dimensional (3-D) graphics that substantially corresponds to the real image. The virtual image may be mapped with the real image. Then, the surveillance camera may be registered in a BIM coordination system using an outcome of the mapping.
摘要:
A process for sensor placement and analysis using a virtual environment includes receiving into a computer processor a model of an area, a position in the model that represents a placement of a virtual sensor, and an orientation of the virtual sensor. A shadow map of the area is generated as a function of the position and orientation of the virtual sensor. The shadow map is used to determine one or more portions of the area that can be sensed by the virtual sensor. The area of the model that is covered as a function of the position and orientation of the virtual sensor is determined, and information relating to the area of the model that is covered as a function of the position and orientation of the virtual sensor is transmitted to an output device.
摘要:
This disclosure provides systems, methods, and apparatus related to freeze casting. In one aspect, a method comprises providing an apparatus. The apparatus comprises a container and a cooling surface. A bottom of the container comprises a wedge. The wedge comprises a first substantially planar surface and a second substantially planar surface with an angle between the first and the second substantially planar surfaces. An interior bottom of the container comprises the second substantially planar surface. The cooling surface is in contact with the first substantially planar surface. A slurry is deposited on the second substantially planar surface, the slurry comprising a plurality of particles in a liquid. The cooling surface is cooled to cool the slurry at a specified cooling rate.