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    Method and apparatus for aligning microbeads in order to interrogate the same
    5.
    发明授权
    Method and apparatus for aligning microbeads in order to interrogate the same 有权
    用于对准微珠以便询问它的方法和装置

    公开(公告)号：US07399643B2

    公开(公告)日：2008-07-15

    申请号：US10661836

    申请日：2003-09-12

    申请人： John Moon ,  Martin A. Putnam ,  Tuo Li ,  Joseph Traynor

    发明人： John Moon ,  Martin A. Putnam ,  Tuo Li ,  Joseph Traynor

    IPC分类号： G01N33/552

    CPC分类号： G03H1/0272 ,  B01J2219/00459 ,  B01J2219/00463 ,  B01J2219/0047 ,  B01J2219/005 ,  B01J2219/00547 ,  B01J2219/00576 ,  B01J2219/00702 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0636 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0487 ,  G03H2210/53 ,  G03H2230/10 ,  G03H2270/20 ,  G03H2270/24 ,  Y10T436/25

    摘要： A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positioning device so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads are typically cylindrically shaped glass beads between 25 and 250 microns (μm) in diameter and between 100 and 500 μm long, and have a holographic code embedded in the central region of the bead, which is used to identify it from the rest of the beads in a batch of beads with many different chemical probes. A cross reference is used to determine which probe is attached to which bead, thus allowing the researcher to correlate the chemical content on each bead with the measured fluorescence signal. Because the code consists of a diffraction grating typically disposed along an axis, there is a particular alignment required between the incident readout laser beam and the readout detector in two of the three rotational axes. The third axis, rotation about the center axis of the cylinder, is azimuthally symmetric and therefore does not require alignment.

    摘要翻译： 提供了一种用于对准光学元件或微珠的方法和装置，其中每个微珠具有细长体，其沿着其纵向轴线嵌入其中的代码，以被代码读取装置读取。 微珠与定位装置对准，使得微珠的纵向轴线相对于代码读取装置定位成固定的取向。 微珠通常为直径为25至250微米（母体）和长度为100至500毫米的圆柱形玻璃珠，并且具有嵌入珠的中心区域中的全息代码，其用于从其余部分识别它 珠子中有一批具有许多不同化学探针的珠粒。 交叉参考用于确定哪个探针连接到哪个珠，从而允许研究者将每个珠上的化学成分与测量的荧光信号相关联。 由于代码由通常沿轴线设置的衍射光栅组成，因此在三个旋转轴中的两个中存在入射读出激光束和读出检测器之间所需的特定对准。 第三轴，围绕气缸的中心轴的旋转是方位对称的，因此不需要对准。

    Hybrid random bead/chip based microarray
    7.
    发明授权
    Hybrid random bead/chip based microarray 有权
    混合随机珠/芯片基微阵列

    公开(公告)号：US07164533B2

    公开(公告)日：2007-01-16

    申请号：US10763995

    申请日：2004-01-22

    申请人： John Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    发明人： John Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    IPC分类号： G02B5/18

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method and apparatus f or performing an assay process, featuring providing microbeads in a solution; placing the microbeads on an alignment substrate; reading codes of the microbeads and the position thereof on the alignment substrate; reading the fluorescence on each microbead and the position order thereof on the alignment substrate; and determining an assay result based on bead position order and bead code of the earlier reading steps, where the microbead is an encoded particle having a particle substrate; a portion of the substrate being made of a substantially single material and having at least one diffraction grating embedded therein, the grating having a resultant refractive index variation within the single material at a grating location; and the grating providing an optical output signal indicative of a code when illuminated by an incident light signal propagating from outside said substrate, the optical output signal being a result of passive, non-resonant scattering from said grating when illuminated by said incident light signal.

    摘要翻译： f或执行测定过程的方法和装置，其特征在于在溶液中提供微珠; 将微珠放置在取向基板上; 读取微珠的代码及其位置; 读取每个微珠上的荧光及其在取向基板上的位置顺序; 并且基于早期阅读步骤的珠粒位置顺序和珠粒码确定测定结果，其中微珠是具有颗粒底物的编码颗粒; 衬底的一部分由基本上单一的材料制成并且具有嵌入其中的至少一个衍射光栅，所述光栅在光栅位置处具有单个材料内的折射率变化; 并且所述光栅提供指示当通过从所述衬底外部传播的入射光信号照射时的代码的光学输出信号，所述光学输出信号是当被所述入射光信号照亮时来自所述光栅的被动的非共振散射的结果。

    Optical grating-based filter
    8.
    发明授权
    Optical grating-based filter 有权
    基于光栅的滤光片

    公开(公告)号：US06834142B2

    公开(公告)日：2004-12-21

    申请号：US10098890

    申请日：2002-03-15

    申请人： Timothy J. Bailey ,  Martin A. Putnam ,  Jay W. Dawson ,  Joseph Pinto ,  James S. Sirkis ,  Paul S. Szczepanek

    发明人： Timothy J. Bailey ,  Martin A. Putnam ,  Jay W. Dawson ,  Joseph Pinto ,  James S. Sirkis ,  Paul S. Szczepanek

    IPC分类号： G02B602

    CPC分类号： G02B6/2932 ,  G02B6/02176 ,  G02B6/0218 ,  G02B6/022 ,  G02B6/266 ,  G02B6/29322 ,  G02B6/29323 ,  G02B6/29395 ,  G02B6/29398

    摘要： An optical filter for filtering a spectral profile of an optical signal for providing an output signal having a desire gain profile, such as a flatten gain profile. The filter comprises an optical waveguide that includes a core disposed within a cladding having an outer dimension greater than 0.3 mm. A Bragg grating is imparted or written in the core of the waveguide that attenuates the received optical input signal in accordance with a defined reflection or transmission filter profile. The Bragg grating may be a slanted grating. The filter profile is complementary to the spectral gain profile of the input signal to provide an output signal having a substantially flat spectral profile of a desired wavelength band. The cladding of the waveguide may have a mechanically advantageous outer geometry (e.g., a “dogbone” shape) for allowing an axial compressive force to tune the Bragg grating. The waveguide may be package within an athermal device, which tunes the grating to compensate for temperature dependent changes. Further, the waveguide may be packaged in a tuning device to selective tune the gratings to shift the center wavelength of the spectral profile of the filter, or to change the shape of the filter profile.

    摘要翻译： 一种滤光器，用于对光信号的光谱分布进行滤波，以提供具有期望增益分布的输出信号，例如平坦增益分布。 滤波器包括光波导，其包括设置在具有大于0.3mm的外部尺寸的包层内的芯。 布拉格光栅被传递或写入波导的核心，根据定义的反射或透射滤波器轮廓衰减接收到的光输入信号。 布拉格光栅可以是倾斜光栅。 滤波器曲线与输入信号的频谱增益分布互补，以提供具有期望波长带的基本上平坦的谱分布的输出信号。 波导的包层可以具有机械有利的外部几何形状（例如，“狗骨”形状），用于允许轴向压缩力调谐布拉格光栅。 波导可以封装在无热器件中，其调谐光栅以补偿温度依赖的变化。 此外，波导可以封装在调谐装置中以选择性调谐光栅以移动滤光器的光谱分布的中心波长，或者改变滤光片的形状。

    Optical reader system for substrates having an optically readable code
    9.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US08333325B2

    公开(公告)日：2012-12-18

    申请号：US13014298

    申请日：2011-01-26

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

    摘要翻译： 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

    Optical reader system for substrates having an optically readable code
    10.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US07900836B2

    公开(公告)日：2011-03-08

    申请号：US12174490

    申请日：2008-07-16

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译： 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。