公开(公告)号：US20070197598A1

公开(公告)日：2007-08-23

申请号：US11598238

申请日：2006-11-13

申请人： Martin Henriksson ,  Evert Homan ,  Lars Johansson ,  Jerk Vallgarda ,  Meredith Williams ,  Eric Bercot ,  Christopher Fotsch ,  Aiwen Li ,  Guolin Cai ,  Randall Hungate ,  Chester Yuan ,  Christopher Tegley ,  David Jean ,  Nianhe Han ,  Qi Huang ,  Qingyian Liu ,  Michael Bartberger ,  George Moniz ,  Matthew Frizzle ,  Teresa Marshall

发明人： Martin Henriksson ,  Evert Homan ,  Lars Johansson ,  Jerk Vallgarda ,  Meredith Williams ,  Eric Bercot ,  Christopher Fotsch ,  Aiwen Li ,  Guolin Cai ,  Randall Hungate ,  Chester Yuan ,  Christopher Tegley ,  David Jean ,  Nianhe Han ,  Qi Huang ,  Qingyian Liu ,  Michael Bartberger ,  George Moniz ,  Matthew Frizzle ,  Teresa Marshall

IPC分类号： A61K31/454 ,  A61K31/4439 ,  A61K31/426 ,  C07D417/02 ,  C07D277/34

CPC分类号： C07D277/54 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

摘要翻译： 本发明涉及噻唑啉酮以及包含该化合物的药物组合物，以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶有关的病症的用途的方法以及用于制备作用于 人类11-β-羟基类固醇脱氢酶1型酶。

公开(公告)号：US20060142357A1

公开(公告)日：2006-06-29

申请号：US11135662

申请日：2005-05-24

申请人： Martin Henriksson ,  Evert Homan ,  Lars Johansson ,  Jerk Vallgarda ,  Meredith Williams ,  Eric Bercot ,  Christopher Fotsch ,  Aiwen Li ,  Guolin Cai ,  Randall Hungate ,  Chester Yuan ,  Christopher Tegley ,  David Jean ,  Nianhe Han ,  Qi Huang ,  Qingyian Liu ,  Michael Bartberger ,  George Moniz ,  Matthew Frizzle

发明人： Martin Henriksson ,  Evert Homan ,  Lars Johansson ,  Jerk Vallgarda ,  Meredith Williams ,  Eric Bercot ,  Christopher Fotsch ,  Aiwen Li ,  Guolin Cai ,  Randall Hungate ,  Chester Yuan ,  Christopher Tegley ,  David Jean ,  Nianhe Han ,  Qi Huang ,  Qingyian Liu ,  Michael Bartberger ,  George Moniz ,  Matthew Frizzle

IPC分类号： A61K31/426 ,  A61K31/421 ,  C07D277/04 ,  C07D263/04

CPC分类号： C07D417/06 ,  C07D263/34 ,  C07D263/48 ,  C07D275/03 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/1804

摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

摘要翻译： 本发明涉及具有式（I），（II），（III）或（IV）的化合物：其中R 1，R 2，R 2， 3，R 4，R 5，R 6，R 7，X和Z分别为 以及包含该化合物的药物组合物的使用方法，以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的病症和用于制备作用于人的药物的方法 11-β-羟基类固醇脱氢酶1型酶。

公开(公告)号：US20070133755A1

公开(公告)日：2007-06-14

申请号：US11638909

申请日：2006-12-14

申请人： David Jean ,  Judy Marcopulos ,  Rita Scherer

发明人： David Jean ,  Judy Marcopulos ,  Rita Scherer

IPC分类号： H04M1/24 ,  H04M3/08 ,  H04M3/22

CPC分类号： H04M3/51 ,  H04M3/08 ,  H04M3/22 ,  H04M3/247 ,  H04M3/26 ,  H04M3/493 ,  H04M2203/1058

摘要： Processes and systems are disclosed for creating and for managing trouble tickets and work orders. One embodiment includes communicating with a communications network and receiving a request to create a trouble ticket. The trouble ticket is created to investigate a problem with a communications system. The trouble ticket is assigned a work item number, with the work item number including a telephone number experiencing the problem with the communications system. The trouble ticket is tracked, from initial creating to final closure, using the assigned work item number.

摘要翻译： 公开了用于创建和管理故障单和工单的过程和系统。 一个实施例包括与通信网络通信并接收创建故障单的请求。 创建故障单以调查通信系统的问题。 为故障单分配了一个工作号码，工作号码包括一个遇到通信系统问题的电话号码。 使用分配的工作项目编号跟踪故障单，从初始创建到最终关闭。

公开(公告)号：US07973677B2

公开(公告)日：2011-07-05

申请号：US12191481

申请日：2008-08-14

申请人： David Jean ,  Laetitia Lambinet ,  Remi Cabaret

发明人： David Jean ,  Laetitia Lambinet ,  Remi Cabaret

IPC分类号： G08B21/00

CPC分类号： H04L67/12

摘要： A system and a method for data transmission between at least one display screen and a remote client system. A first request to send a message via a first communication protocol is caused to be displayed on the display screen, and the message is transmitted to the remote client system via a second communication protocol. A control unit monitors the remote client system. The system induces the generation, and display on the display screen, of a request for confirmation of the first request, by the intermediary of a communication interface, which interface is designed to receive and generate messages in the first communication protocol, as well as to receive and generate messages suitable for being received by the control unit.

摘要翻译： 一种在至少一个显示屏和远程客户端系统之间进行数据传输的系统和方法。 使得经由第一通信协议发送消息的第一请求被显示在显示屏幕上，并且该消息经由第二通信协议被发送到远程客户端系统。 控制单元监视远程客户端系统。 该系统通过通信接口的中介，在显示屏幕上产生和显示对第一请求的确认请求，该通信接口被设计为在第一通信协议中接收和生成消息，以及 接收并产生适合于由控制单元接收的消息。

公开(公告)号：US20100029848A1

公开(公告)日：2010-02-04

申请号：US12304924

申请日：2007-06-19

申请人： Anna Forlin ,  Massimo Bergamo ,  Wells Carter ,  David Jean

发明人： Anna Forlin ,  Massimo Bergamo ,  Wells Carter ,  David Jean

IPC分类号： C08G65/22 ,  C07D301/03 ,  C08L63/00

CPC分类号： C07D301/12 ,  C07D303/38

摘要： A process for producing an epoxide such as a cycloaliphatic diepoxide by the reaction of an olefin such as a cycloaliphatic diene with hydrogen peroxide (H2O2) as an oxidant in the presence of a catalytic system under pH control for example at a pH of less than about 5. The present invention is advantageously used for the epoxidation of olefinic compounds such as olefins and aliphatic or aromatic dienes.

摘要翻译： 在pH控制下，例如在小于约pH的pH控制下，在催化体系存在下，通过烯烃如脂环族二烯与过氧化氢（H 2 O 2）作为氧化剂的反应来制备环氧化物如环脂族二环氧化物的方法， 本发明有利地用于烯烃化合物如烯烃和脂族或芳族二烯烃的环氧化。

公开(公告)号：US09187403B2

公开(公告)日：2015-11-17

申请号：US13383325

申请日：2010-07-30

申请人： Stacie Santhany ,  Patrick Ho Sing Au-Yeung ,  Gerald W. Dare ,  Shawn D. Feist ,  Barry B. Fish ,  Daniel A. Hickman ,  David Jean ,  Erich J. Molitor ,  Abraham D. Schuitman ,  Todd William Toyzan

发明人： Stacie Santhany ,  Patrick Ho Sing Au-Yeung ,  Gerald W. Dare ,  Shawn D. Feist ,  Barry B. Fish ,  Daniel A. Hickman ,  David Jean ,  Erich J. Molitor ,  Abraham D. Schuitman ,  Todd William Toyzan

IPC分类号： C07C209/00 ,  C07C209/86

CPC分类号： C07C209/86 ,  C07C2601/14 ,  C07C211/28

摘要： The instant invention provides a process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities, and aliphatic diamines obtained via such a process. The process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities according to the instant invention comprises the steps of: (1) feeding one or more cycloaliphatic cyanoaldehydes, hydrogen, ammonia, and optionally one or more solvents into a continuous reductive amination reactor system; (2) contacting said one or more cycloaliphatic cyanoaldehydes, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C. and a pressure in the range of from 700 to 3500 psig; (3) thereby forming a product mixture comprising one or more cycloaliphatic diamines, optionally one or more bicyclic by-products, optionally one or more cycloaliphatic aminonitriles, optionally one or more cycloaliphatic aminoalcohols, optionally one or more oligomeric by-products, ammonia, water, hydrogen, and optionally one or more solvents; (4) removing said product mixture from the reactor system; (5) removing at least a portion of said ammonia, said hydrogen, or mixture thereof from said product mixture via distillation; (6) removing at least a portion of said water and said one or more optional solvents via distillation; (7) removing at least a portion of one or more optional bicyclic by-products via distillation; (8) removing one or more optional cycloaliphatic aminonitriles, one or more optional cycloaliphatic aminoalcohols, one or more optional oligomeric by-products via distillation; and (9) thereby separating said one or more cycloaliphatic diamines from said product mixture.

公开(公告)号：US08716502B2

公开(公告)日：2014-05-06

申请号：US13990451

申请日：2011-12-07

申请人： Leming Gu ,  William W. Fan ,  David Jean ,  Eric B. Ripplinger ,  Bruce D. Hook ,  David H. West

发明人： Leming Gu ,  William W. Fan ,  David Jean ,  Eric B. Ripplinger ,  Bruce D. Hook ,  David H. West

IPC分类号： C07D301/03 ,  C07D301/12

CPC分类号： C07D301/16 ,  C07D303/04

摘要： A process for preparing a divinylarene oxide including (a) reacting (i) at least one divinylarene; (ii) at least one peroxycarboximidic acid; (iii) at least one solvent; and (iv) at least one basic compound, under reaction conditions to form a reaction effluent containing a divinylarene oxide product; and then (b) evaporating the reaction effluent of step (a) to form a concentrate containing the divinylarene oxide product; and wherein the concentrate separates into two liquid phases.

摘要翻译： 一种制备二乙烯基芳烃氧化物的方法，包括（a）使（i）至少一种二乙烯基芳烃反应; （ii）至少一种过氧羧甲酸; （iii）至少一种溶剂; 和（iv）至少一种碱性化合物，在反应条件下形成含有二乙烯基芳烃氧化物产物的反应流出物; 然后（b）蒸发步骤（a）的反应流出物以形成含有二乙烯基芳氧化物产物的浓缩物; 并且其中所述浓缩物分离成两个液相。

公开(公告)号：US08656313B2

公开(公告)日：2014-02-18

申请号：US12118494

申请日：2008-05-09

申请人： Remi Cabaret ,  David Jean ,  Nicolas Roux

发明人： Remi Cabaret ,  David Jean ,  Nicolas Roux

IPC分类号： G06F3/048 ,  G05D1/00

CPC分类号： G06F3/038 ,  G06F3/0481 ,  G06F2203/0382

摘要： A display system manages the states of two cursors that are situated on an interactive window of a display screen, as a function of the last actions carried out by the crew.

摘要翻译： 显示系统根据机组人员执行的最后动作来管理位于显示屏幕的交互式窗口上的两个光标的状态。

公开(公告)号：US08669384B2

公开(公告)日：2014-03-11

申请号：US13581333

申请日：2011-03-04

申请人： Eric B. Ripplinger ,  David Jean ,  David Burow ,  Khiet Pham ,  Maurice Marks ,  Gyongyi Gulyas

发明人： Eric B. Ripplinger ,  David Jean ,  David Burow ,  Khiet Pham ,  Maurice Marks ,  Gyongyi Gulyas

IPC分类号： C07D301/06

CPC分类号： C07D407/10 ,  C07D301/03 ,  C07D301/26 ,  C08G59/027 ,  C08G59/22

摘要： A process for preparing a divinylarene dioxide including (a) reacting at least one divinylarene with hypochlorous acid to form a chlorohydrin; and (b) treating the chlorohydrin formed in step (a) with at least one base, under conditions to form a divinylarene dioxide product.

摘要翻译： 一种制备二乙烯基芳烃二氧化物的方法，包括（a）使至少一种二乙烯基芳烃与次氯酸反应以形成氯代醇; 和（b）在条件下用至少一种碱处理步骤（a）中形成的氯代醇，以形成二乙烯基二氧化碳产品。

公开(公告)号：US20130267720A1

公开(公告)日：2013-10-10

申请号：US13990451

申请日：2011-12-07

申请人： Leming Gu ,  William W. Fan ,  David Jean ,  Eric B. Ripplinger ,  Bruce D. Hook ,  David H. West

发明人： Leming Gu ,  William W. Fan ,  David Jean ,  Eric B. Ripplinger ,  Bruce D. Hook ,  David H. West

IPC分类号： C07D301/16

CPC分类号： C07D301/16 ,  C07D303/04

摘要： A process for preparing a divinylarene oxide including (a) reacting (i) at least one divinylarene; (ii) at least one peroxycarboximidic acid; (iii) at least one solvent; and (iv) at least one basic compound, under reaction conditions to form a reaction of fluent containing a divinylarene oxide product; and then (b) evaporating the reaction effluent of step (a) to form a concentrate containing the divinylarene oxide product; and wherein the concentrate separates into two liquid phases.

摘要翻译： 一种制备二乙烯基芳烃氧化物的方法，包括（a）使（i）至少一种二乙烯基芳烃反应; （ii）至少一种过氧羧甲酸; （iii）至少一种溶剂; 和（iv）至少一种碱性化合物，在反应条件下形成含有二乙烯基芳烃氧化物产物的流动反应; 然后（b）蒸发步骤（a）的反应流出物以形成含有二乙烯基芳氧化物产物的浓缩物; 并且其中所述浓缩物分离成两个液相。