公开(公告)号：US06830914B2

公开(公告)日：2004-12-14

申请号：US09894749

申请日：2001-06-27

申请人： Martin R. Hodge ,  David Yowe

发明人： Martin R. Hodge ,  David Yowe

IPC分类号： C12N900

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的RGS多肽，蛋白质和核酸分子。 除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。 本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US06274362B1

公开(公告)日：2001-08-14

申请号：US09244314

申请日：1999-02-04

申请人： Martin R. Hodge ,  David Yowe

发明人： Martin R. Hodge ,  David Yowe

IPC分类号： C12N916

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的RGS多肽，蛋白质和核酸分子。 除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。 本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US06410240B1

公开(公告)日：2002-06-25

申请号：US09498959

申请日：2000-02-04

申请人： Martin R. Hodge ,  David Yowe

发明人： Martin R. Hodge ,  David Yowe

IPC分类号： C12Q168

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的RGS多肽，蛋白质和核酸分子。 除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。 本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US08710192B2

公开(公告)日：2014-04-29

申请号：US12965743

申请日：2010-12-10

申请人： Sarah Rue ,  Steve B. Cohen ,  Jun Li ,  David Yowe

发明人： Sarah Rue ,  Steve B. Cohen ,  Jun Li ,  David Yowe

IPC分类号： C07K16/40 ,  C07K16/00 ,  A61K39/395

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides antibody antagonists against proprotein convertase subtilisin/kexin type 9a (“PCSK9”) and methods of using such antibodies.

摘要翻译： 本发明提供抗前体蛋白转化酶枯草杆菌蛋白酶/ kexin型9a（“PCSK9”）的抗体拮抗剂和使用这些抗体的方法。

公开(公告)号：US06326481B1

公开(公告)日：2001-12-04

申请号：US09324455

申请日：1999-06-02

申请人： David Yowe

发明人： David Yowe

IPC分类号： C07K100

CPC分类号： C07K14/4747 ,  A01K2217/05 ,  A61K38/00

摘要： Novel AIP-6 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length AIP-6 proteins, the invention further provides isolated AIP-6 fusion proteins, antigenic peptides and anti-AIP-6 antibodies. The invention also provides AIP-6 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a AIP-6 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新型的AIP-6多肽，蛋白质和核酸分子。 除了分离的全长AIP-6蛋白，本发明还提供分离的AIP-6融合蛋白，抗原肽和抗AIP-6抗体。 本发明还提供了AIP-6核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了AIP-6基因的非人转基因动物，或 中断了 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20050153414A1

公开(公告)日：2005-07-14

申请号：US10989054

申请日：2004-11-15

申请人： Martin Hodge ,  David Yowe

发明人： Martin Hodge ,  David Yowe

IPC分类号： G01N33/53 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/566 ,  C12N9/16

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的RGS多肽，蛋白质和核酸分子。 除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。 本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。