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7 条记录 (耗时 0.042 秒)

    Novel RGS-containing molecules and uses thereof
    1.
    发明申请
    Novel RGS-containing molecules and uses thereof 审中-公开
    新型含RGS的分子及其用途

    公开(公告)号：US20050153414A1

    公开(公告)日：2005-07-14

    申请号：US10989054

    申请日：2004-11-15

    申请人： Martin Hodge ,  David Yowe

    发明人： Martin Hodge ,  David Yowe

    IPC分类号： G01N33/53 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/566 ,  C12N9/16

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

    摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的RGS多肽，蛋白质和核酸分子。 除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。 本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    Novel kinases and uses thereof
    2.
    发明申请
    Novel kinases and uses thereof 失效
    新型激酶及其用途

    公开(公告)号：US20060141524A1

    公开(公告)日：2006-06-29

    申请号：US11358419

    申请日：2006-02-21

    申请人： Martin Hodge

    发明人： Martin Hodge

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12 ,  C07K16/40

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diganositc, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新型激酶多肽，蛋白质和核酸分子。 除了分离的全长激酶蛋白之外，本发明还提供分离的激酶融合蛋白，抗原肽和抗激酶抗体。 本发明还提供了激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已经导入或破坏了激酶基因的非人类转基因动物。 还提供了使用本发明组合物的Diganositc，筛选和治疗方法。

    Novel nucleic acid sequences encoding G-protein coupled receptors
    5.
    发明申请
    Novel nucleic acid sequences encoding G-protein coupled receptors 审中-公开
    编码G蛋白偶联受体的新型核酸序列

    公开(公告)号：US20060275866A1

    公开(公告)日：2006-12-07

    申请号：US11268745

    申请日：2005-11-07

    申请人： Katherine Galvin ,  Maria Glucksmann ,  Martin Hodge ,  John Hunter ,  Laura Rudolph-Owen ,  Inmaculada Silos-Santiago ,  Nadine Weich

    发明人： Katherine Galvin ,  Maria Glucksmann ,  Martin Hodge ,  John Hunter ,  Laura Rudolph-Owen ,  Inmaculada Silos-Santiago ,  Nadine Weich

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acids molecules, designated 2871, 14926, 44576, 23992, 1983, 52881, 2398, and 52872 nucleic acid molecules, which encode novel G protein-coupled receptor family members that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 gene has been introduced or disrupted. The invention still further provides isolated 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 proteins, fusion proteins, antigenic peptides and anti-2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为2871,14926,4457,239992,1983,52881,2988和52872核酸分子，其编码编码新多肽的新型G蛋白偶联受体家族成员。 本发明还提供反义核酸分子，含有2871,14926,4576,23992,1983,52881,2398或52872核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人转基因动物，其中 已经引入或破坏了2871,14926,44576,23992,1983,52881,2398或52872基因。 本发明还进一步提供了分离的2871,14926,4457,239992,1983,52881,2398或52872蛋白质，融合蛋白，抗原肽和抗-2871,14926,4457,23992,1983,52881,29898或52872抗体。 还提供了利用本发明组合物的诊断方法。

    Methods for identification of ligands or modulators of 2871 receptor, a G-protein coupled receptor
    6.
    发明申请
    Methods for identification of ligands or modulators of 2871 receptor, a G-protein coupled receptor 审中-公开
    鉴定2871受体，G蛋白偶联受体的配体或调节剂的方法

    公开(公告)号：US20050136472A1

    公开(公告)日：2005-06-23

    申请号：US11051689

    申请日：2005-02-04

    申请人： Martin Hodge ,  Guiquan Jia

    发明人： Martin Hodge ,  Guiquan Jia

    IPC分类号： G01N33/566 ,  G01N33/74 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  G01N33/574

    CPC分类号： G01N33/74 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

    摘要： The present invention relates to ligand identification for the 2871 G-protein-coupled receptor. The invention also relates to methods for identification of agents which can bind 2871 receptor protein and/or modulate 2871 receptor protein function. The invention further relates to agents which bind 2871 receptor protein. The invention further encompasses agents (e.g., agonists and antagonists) which modulate 2871 receptor protein function. The invention further relates to methods of modulating 2871 receptor protein function, and to the use of agents (e.g., agonists and antagonists) in methods for diagnosis and treatment of 2871 receptor related disorders.

    摘要翻译： 本发明涉及2871 G蛋白偶联受体的配体鉴定。 本发明还涉及可以结合2871受体蛋白质和/或调节2871受体蛋白质功能的药剂的鉴定方法。 本发明还涉及结合2871受体蛋白的试剂。 本发明还包括调节2871受体蛋白功能的药剂（例如激动剂和拮抗剂）。 本发明还涉及调节2871受体蛋白功能的方法，以及在诊断和治疗2871受体相关病症的方法中使用试剂（例如激动剂和拮抗剂）。

    Novel kinases and uses thereof
    7.
    发明申请
    Novel kinases and uses thereof 审中-公开
    新型激酶及其用途

    公开(公告)号：US20050089917A1

    公开(公告)日：2005-04-28

    申请号：US10989228

    申请日：2004-11-15

    申请人： Martin Hodge

    发明人： Martin Hodge

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12N9/12 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新型激酶多肽，蛋白质和核酸分子。 除了分离的全长激酶蛋白之外，本发明还提供分离的激酶融合蛋白，抗原肽和抗激酶抗体。 本发明还提供了激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已经导入或破坏了激酶基因的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。