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公开(公告)号：US06744848B2
公开(公告)日：2004-06-01
申请号：US09781787
申请日：2001-02-12
IPC分类号： G01B1502
CPC分类号： A61B6/466 , A61B6/032 , A61B6/4085 , A61B6/4488 , A61B6/502 , G01B15/025 , G01N23/046 , G01N2223/419 , G06T11/006 , G06T2211/436
摘要： The present invention provides a system for imaging an object by irradiating it with low doses of radiation, such as x-ray, from a plurality of positions angularly distributed about the object, and analyzing the intensity of the radiation transmitted through the object. A system according to the invention can include a radiation source, a low noise detector, and an image processor. The radiation source emits radiation toward a target scene, containing an object to be imaged, from a plurality of angular positions. In one embodiment, the plurality of angular positions defines an arc about the target scene. In another embodiment, the radiation source moves in a series of steps of varying angular spacing along the arc to generate the multiple images of the scene. The detector is positioned to detect radiation transmitted through the scene and produces radiation transmission data representing the intensity of the radiation transmitted through the scene. The image processor receives the radiation transmission data from the detector and produces a three-dimensional image of the scene. In some embodiments of the invention, the resolution of the detector can be varied. In such embodiments, the system of the invention further includes a resolution controller that varies the spatial resolution of the detector in response to the angular position from which radiation is emitted toward the scene.
摘要翻译： 本发明提供了一种用于通过从关于物体分布的多个位置的低剂量辐射（例如x射线）照射物体并分析透过物体的辐射的强度来对物体进行成像的系统。 根据本发明的系统可以包括辐射源，低噪声检测器和图像处理器。 辐射源从多个角位置向包含待成像对象的目标场景发射辐射。 在一个实施例中，多个角位置限定关于目标场景的弧。 在另一个实施例中，辐射源沿着弧线改变角度间隔的一系列步骤移动，以产生场景的多个图像。 检测器被定位成检测通过场景传播的辐射，并产生表示通过场景传播的辐射的强度的辐射传输数据。 图像处理器从检测器接收辐射传输数据，并产生场景的三维图像。 在本发明的一些实施例中，可以改变检测器的分辨率。 在这样的实施例中，本发明的系统还包括分辨率控制器，其响应于向其发射辐射的角位置来改变检测器的空间分辨率。
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公开(公告)号：US20090274272A1
公开(公告)日：2009-11-05
申请号：US12497074
申请日：2009-07-02
IPC分类号： G01N23/04 , G01N23/201 , G06K9/00
CPC分类号： A61B6/482 , A61B6/02 , A61B6/405 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/5258 , A61B6/542 , G01N23/04 , G01N2223/423
摘要： In one aspect, A method of imaging an object of interest positioned in an exposure area is provided. The method comprises obtaining projection data of the object by providing radiation to the exposure area and detecting at least some of the radiation exiting the object to form the projection data, performing a first reconstruction of the projection data to form at least one bootstrap image, obtaining first data based on information provided by the at least one bootstrap image, and performing a second reconstruction of the projection data based, at least in part, on the first data to form at least one second image.
摘要翻译： 在一个方面，提供了一种对曝光区域中的感兴趣物体进行成像的方法。 该方法包括：通过向曝光区域提供辐射并检测离开物体的至少一些辐射以形成投影数据，执行投影数据的第一重建以形成至少一个自举图像，获得物体的投影数据，获得 基于由所述至少一个自举图像提供的信息的第一数据，以及至少部分地基于第一数据执行投影数据的第二重建以形成至少一个第二图像。
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公开(公告)号：US08071734B2
公开(公告)日：2011-12-06
申请号：US11645362
申请日：2006-12-22
IPC分类号： C07H21/04
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00387 , B01J2219/005 , B01J2219/00529 , B01J2219/00576 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0072 , C40B30/04 , C40B40/06 , C40B60/12 , C40B70/00 , G01N21/6458 , G01N21/648
摘要： The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to a non-nucleotide target molecule, such as a protein, a steroid, or an inorganic molecule. New aptamer beacons having binding regions configured to bind to different target molecules can be used in solution-based and solid, array-based systems. The aptamer beacons can be attached to solid supports, e.g., at different predetermined points in two-dimensional arrays. The invention includes devices, methods, and computer software for carrying out the methods.
摘要翻译： 本发明涉及用于使用适配子信标同时检测样品中一种或多种不同化合物的存在和量的组合物，系统和方法。 适配器信标是具有可结合非核苷酸靶分子如蛋白质，类固醇或无机分子的结合区的寡核苷酸。 具有配置成结合不同靶分子的结合区域的新适配子信标可用于基于溶液和固体的基于阵列的体系。 适配器信标可以连接到固体支持物，例如在二维阵列中的不同预定点处。 本发明包括用于执行方法的装置，方法和计算机软件。
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公开(公告)号：US20090262893A1
公开(公告)日：2009-10-22
申请号：US12463491
申请日：2009-05-11
IPC分类号： G01N23/04
CPC分类号： A61B6/482 , A61B6/02 , A61B6/4035 , A61B6/405 , A61B6/4085 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/542 , A61B6/583 , G01N23/046 , G01N2223/419 , G01N2223/423 , G01N2223/612
摘要： In one aspect, a method of obtaining projection data of an object from a plurality of view angles with respect to the object is provided. The method comprises acts of providing radiation, at each of the plurality of view angles, to an exposure area in which the object is positioned, controlling a radiation energy of the radiation provided at each of the plurality of view angles such that the respective radiation energy is different for at least two of the plurality of view angles, and detecting at least some of the radiation passing through the exposure area at each of the plurality of view angles to obtain the projection data.
摘要翻译： 一方面，提供从多个视角相对于物体获取物体的投影数据的方法。 该方法包括在多个视角中的每一个处将辐射提供给物体所在的曝光区域的动作，控制在多个视角中的每一个处提供的辐射的辐射能量，使得相应的辐射能量 对于多个视角中的至少两个视角不同，并且在多个视角中的每一个处检测通过曝光区域的至少一些辐射，以获得投影数据。
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公开(公告)号：US07570732B2
公开(公告)日：2009-08-04
申请号：US11603876
申请日：2006-11-22
IPC分类号： G01N23/04
CPC分类号： A61B6/482 , A61B6/02 , A61B6/405 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/5258 , A61B6/542 , G01N23/04 , G01N2223/423
摘要： In one aspect, A method of imaging an object of interest positioned in an exposure area is provided. The method comprises obtaining projection data of the object by providing radiation to the exposure area and detecting at least some of the radiation exiting the object to form the projection data, performing a first reconstruction of the projection data to form at least one bootstrap image, obtaining first data based on information provided by the at least one bootstrap image, and performing a second reconstruction of the projection data based, at least in part, on the first data to form at least one second image.
摘要翻译： 在一个方面，提供了一种对曝光区域中的感兴趣物体进行成像的方法。 该方法包括：通过向曝光区域提供辐射并检测离开物体的至少一些辐射以形成投影数据，执行投影数据的第一重建以形成至少一个自举图像，获得物体的投影数据，获得 基于由所述至少一个自举图像提供的信息的第一数据，以及至少部分地基于第一数据执行投影数据的第二重建以形成至少一个第二图像。
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公开(公告)号：US20080020939A1
公开(公告)日：2008-01-24
申请号：US11645362
申请日：2006-12-22
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00387 , B01J2219/005 , B01J2219/00529 , B01J2219/00576 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0072 , C40B30/04 , C40B40/06 , C40B60/12 , C40B70/00 , G01N21/6458 , G01N21/648
摘要： The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to a non-nucleotide target molecule, such as a protein, a steroid, or an inorganic molecule. New aptamer beacons having binding regions configured to bind to different target molecules can be used in solution-based and solid, array-based systems. The aptamer beacons can be attached to solid supports, e.g., at different predetermined points in two-dimensional arrays. The invention includes devices, methods, and computer software for carrying out the methods.
摘要翻译： 本发明涉及用于使用适配子信标同时检测样品中一种或多种不同化合物的存在和量的组合物，系统和方法。 适配器信标是具有可结合非核苷酸靶分子如蛋白质，类固醇或无机分子的结合区的寡核苷酸。 具有配置成结合不同靶分子的结合区域的新适配子信标可用于基于溶液和固体的基于阵列的体系。 适配器信标可以连接到固体支持物，例如在二维阵列中的不同预定点处。 本发明包括用于执行方法的装置，方法和计算机软件。
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公开(公告)号：US20070242868A1
公开(公告)日：2007-10-18
申请号：US11603844
申请日：2006-11-22
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G01N23/046 , G01N2223/419
摘要： In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution.
摘要翻译： 一方面，提供一种显示数据的方法。 该方法包括通过以多个视角将物体暴露于辐射并且检测出离开物体的至少一些辐射以形成投影数据来获得物体的投影数据，操作计算机以重建分辨率重建投影数据 为了形成包括表示对象内的位置的多个体素的图像数据，多个体素中的每一个被分配指示相应位置处的主体密度的相关强度，确定用于显示的最大分辨率， 投影数据中的信息不支持相邻体素之间的强度，最大分辨率小于重建分辨率，并且以最大分辨率或低于最大分辨率显示图像数据。
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公开(公告)号：US20110012897A1
公开(公告)日：2011-01-20
申请号：US12842480
申请日：2010-07-23
CPC分类号： G06T11/008 , G01N23/046 , G01N2223/419
摘要： In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution.
摘要翻译： 一方面，提供一种显示数据的方法。 该方法包括通过以多个视角将物体暴露于辐射并且检测出离开物体的至少一些辐射以形成投影数据来获得物体的投影数据，操作计算机以重建分辨率重建投影数据 为了形成包括表示对象内的位置的多个体素的图像数据，多个体素中的每一个被分配指示相应位置处的主体密度的相关强度，确定用于显示的最大分辨率， 投影数据中的信息不支持相邻体素之间的强度，最大分辨率小于重建分辨率，并且以最大分辨率或低于最大分辨率显示图像数据。
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公开(公告)号：US07817773B2
公开(公告)日：2010-10-19
申请号：US11620214
申请日：2007-01-05
CPC分类号： G01N23/046 , A61B6/466 , A61B6/502 , G01N2223/419 , G01T1/2985
摘要： A method and apparatus for imaging an object including the steps of projecting radiation from a radiation source through an object and moving the radiation source through multiple imaging positions relative to the object without stopping movement of the radiation source. Movement is accomplished while projecting radiation at more than one of the imagining positions with the source having a source velocity for at least one imaging position that is different from a source velocity for a second imaging position. Radiation transmitted through the object is also detected. Radiation may be projected while moving the radiation source through the multiple imaging positions. In addition, the velocity at which the radiation source is moved through a select imaging position may be related to a resolution desired for data collection at the select imaging position. The velocity of the radiation source may be varied within a select imaging position. Furthermore, the motion of the radiation source may be stopped at one or more of the imaging positions.
摘要翻译： 一种用于对物体成像的方法和装置，包括以下步骤：将来自辐射源的辐射投射通过物体，并且使辐射源相对于物体移动多个成像位置，而不停止辐射源的移动。 在多于一个想象位置处投影辐射的同时实现移动，其中源具有与第二成像位置的源速度不同的至少一个成像位置的源速度。 也检测到透过物体的辐射。 当辐射源通过多个成像位置移动时，可以投影辐射。 此外，辐射源移动通过选择成像位置的速度可以与在选择成像位置处的数据收集所需的分辨率相关。 辐射源的速度可以在选择的成像位置内变化。 此外，可以在一个或多个成像位置停止辐射源的运动。
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公开(公告)号：US07545907B2
公开(公告)日：2009-06-09
申请号：US11595664
申请日：2006-11-09
IPC分类号： A61B6/04
CPC分类号： A61B6/482 , A61B6/02 , A61B6/4035 , A61B6/405 , A61B6/4085 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/542 , A61B6/583 , G01N23/046 , G01N2223/419 , G01N2223/423 , G01N2223/612
摘要： In one aspect, a method of obtaining projection data of an object from a plurality of view angles with respect to the object is provided. The method comprises acts of providing radiation, at each of the plurality of view angles, to an exposure area in which the object is positioned, controlling a radiation energy of the radiation provided at each of the plurality of view angles such that the respective radiation energy is different for at least two of the plurality of view angles, and detecting at least some of the radiation passing through the exposure area at each of the plurality of view angles to obtain the projection data.
摘要翻译： 一方面，提供从多个视角相对于物体获取物体的投影数据的方法。 该方法包括在多个视角中的每一个处将辐射提供给物体所在的曝光区域的动作，控制在多个视角中的每一个处提供的辐射的辐射能量，使得相应的辐射能量 对于多个视角中的至少两个视角不同，并且在多个视角中的每一个处检测通过曝光区域的至少一些辐射，以获得投影数据。
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