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    Fluorescent and DNA cleavage properties of peptide/dye conjugates
    1.
    发明授权
    Fluorescent and DNA cleavage properties of peptide/dye conjugates 失效
    肽/染料缀合物的荧光和DNA切割性质

    公开(公告)号：US06348317B1

    公开(公告)日：2002-02-19

    申请号：US09713950

    申请日：2000-11-16

    申请人： Martin Thompson ,  Neal W. Woodbury

    发明人： Martin Thompson ,  Neal W. Woodbury

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6825 ,  C07K14/721 ,  C12Q2563/125 ,  C12Q2563/107

    摘要： A method of identifying the presence or absence of a DNA molecule in a test sample comprising a specific DNA sequence is disclosed. In one embodiment, the method comprises the steps of mixing a test sample with a peptide/dye conjugate comprising a covalently linked peptide and a dye, wherein the peptide binds to the specific DNA sequence and wherein the peptide/dye conjugate will fluoresce if the peptide is bound to the specific DNA sequence, and measuring fluorescence, wherein specific fluorescence above background level indicates that the conjugate is bound to the specific DNA sequence. In another embodiment, the present invention is a method of cleaving a specific DNA molecule and a test sample. The method comprises mixing a test sample with a peptide dye conjugate comprising a covalently linked peptide and a dye, wherein the peptide binds to the specific DNA sequence and wherein the peptide dye conjugate will cleave if the peptide is bound to a specific DNA sequence.

    摘要翻译： 公开了一种鉴定包含特定DNA序列的测试样品中DNA分子的存在或不存在的方法。 在一个实施方案中，该方法包括以下步骤：将测试样品与包含共价连接的肽和染料的肽/染料缀合物混合，其中所述肽结合特异性DNA序列，并且其中肽/染料缀合物将如果肽 与特定DNA序列结合，并测量荧光，其中高于背景水平的特异性荧光指示缀合物与特定DNA序列结合。 在另一个实施方案中，本发明是切割特定DNA分子和测试样品的方法。 该方法包括将测试样品与包含共价连接的肽和染料的肽染料缀合物混合，其中所述肽结合特异性DNA序列，并且其中肽染料缀合物如果肽与特定DNA序列结合则将切割。

    SYSTEMS, METHODS, AND MEDIA FOR MOLECULE DESIGN USING MACHINE LEARNING MECHANISMS
    4.
    发明申请
    SYSTEMS, METHODS, AND MEDIA FOR MOLECULE DESIGN USING MACHINE LEARNING MECHANISMS 有权

    公开(公告)号：US20220130494A1

    公开(公告)日：2022-04-28

    申请号：US17427786

    申请日：2020-02-11

    申请人： Neal W. Woodbury ,  Alexander T. Taguchi

    发明人： Neal W. Woodbury ,  Alexander T. Taguchi

    IPC分类号： G16C20/50 ,  G16B40/10 ,  G16B40/20

    摘要： Mechanisms for molecule design using machine learning include: forming a first training set for a neural network using, for each of a first plurality of known molecules, a plurality of input values that represent the structure of the known molecule and a plurality of functional property values for the known molecule; training the neural network using the first training set; proposing a first plurality of proposed molecules, and predicting first predicted functional property values of the first plurality of proposed molecules that have the desired function property values; causing the first plurality of proposed molecules to be synthesized to form a first plurality of synthesized molecules; receiving first measured functional property values of the first plurality of synthesized molecules; and adding data regarding the first plurality of synthesized molecules to the first training set to form a second training set and retrain the neural network using the second training set.

    MICROARRAY OF THREE-DIMENSIONAL HETEROPOLYMER MICROSTRUCTURES AND METHOD THEREFOR
    5.
    发明申请
    MICROARRAY OF THREE-DIMENSIONAL HETEROPOLYMER MICROSTRUCTURES AND METHOD THEREFOR 审中-公开
    三维异构体微结构微观结构及其方法

    公开(公告)号：US20090042741A1

    公开(公告)日：2009-02-12

    申请号：US10599770

    申请日：2005-05-06

    申请人： Trent R. Northen ,  Neal W. Woodbury

    发明人： Trent R. Northen ,  Neal W. Woodbury

    IPC分类号： C40B40/14 ,  C40B50/14

    CPC分类号： G01N33/54386 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00644 ,  B01J2219/00722 ,  B01J2219/00725

    摘要： A microarray has a substrate and a plurality of three-dimensional microstructures formed on the substrate. Each of the three-dimensional microstructures is made with polymer material and has a plurality of reactive sites formed on its surface and interior pores. The polymer material is polymer gel or other porous polymer. The combination of three-dimensional microstructure and porous polymer material increases the surface area of the microstructure and density of the reactive sites on the surface of the microstructures. The higher density of reactive sites increases the luminescence, visibility or instrument detectability of the interaction between analytes and reactive microstructure sites on the microarray. A plurality of chemical groups are respectively attached to the reactive sites. The chemical groups each include at least one monomer. The chemical groups may have different chemical structures. A plurality of microchannels can be formed around the microstructures for isolation.

    摘要翻译： 微阵列具有在基板上形成的基板和多个三维微结构。 每个三维微结构由聚合物材料制成，并且在其表面和内部孔上形成多个反应性位点。 聚合物材料是聚合物凝胶或其它多孔聚合物。 三维微结构和多孔聚合物材料的组合增加了微观结构的表面积和微结构表面上的反应位点的密度。 反应性位点的较高密度增加了微阵列上分析物和反应性微结构位点之间的相互作用的发光，可见性或仪器可检测性。 多个化学基团分别连接到反应性位点。 化学基团各自包含至少一种单体。 化学基团可能具有不同的化学结构。 可以在微结构周围形成多个微通道用于隔离。