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    FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS
    8.
    发明申请
    FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS 审中-公开
    含有吡啶化合物的配方

    公开(公告)号：US20090325973A1

    公开(公告)日：2009-12-31

    申请号：US12298652

    申请日：2007-04-27

    申请人： D. Martin Watterson ,  Linda Van Eldik ,  Wenhui Hu

    发明人： D. Martin Watterson ,  Linda Van Eldik ,  Wenhui Hu

    IPC分类号： A61K31/501 ,  C07D403/04

    CPC分类号： A61K31/506 ,  A61K31/501 ,  C07D237/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

    摘要： The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula I are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, ═O, ═S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications.

    摘要翻译： 本发明涉及化合物，组合物和制备和使用它们的方法。 特别地，本发明提供选择的式I的哒嗪化合物独立地是氢，羟基，烷基，烯基，炔基，亚烷基，亚烯基，烷氧基，烯氧基，环烷基，环烯基，环炔基，环烷氧基，芳基，芳氧基，芳基烷氧基，芳酰基， 杂环，酰基，酰氧基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，硫酸根，亚磺酰基，亚磺酰基，磺酰基，磺酸酯，亚砜，甲硅烷基，甲硅烷氧基，甲硅烷基烷基，甲硅烷硫基， -S，膦酸酯，脲基，羧基，羰基，氨基甲酰基或甲酰胺; X是任选取代的嘧啶基或哒嗪基，异构体，药用盐或其衍生物。 本发明另外涉及包含该化合物的组合物，以及使用该化合物和组合物调节细胞途径，用于治疗或预防炎性疾病，用于研究，药物筛选和治疗应用的方法。