公开(公告)号：US20080274532A1

公开(公告)日：2008-11-06

申请号：US11663440

申请日：2006-03-15

申请人： Masaaki Minamoto ,  Kazuhiko Shimada

发明人： Masaaki Minamoto ,  Kazuhiko Shimada

IPC分类号： C12N9/74 ,  C12N9/48 ,  C12M1/16

CPC分类号： C12Q1/56 ,  C12N9/6429 ,  C12N9/96 ,  C12N13/00 ,  C12Y304/21005 ,  G01N33/86

摘要： The present invention provides a blood coagulation accelerator excellent under severe conditions at ordinary or higher temperatures and capable of exhibiting high blood coagulation performance stably over a long period of time, as well as a container for blood examination wherein the blood coagulation accelerator is accommodated. Disclosed is a blood coagulation accelerator comprising an enzyme capable of hydrolyzing in a peptide chain a bond between arginine and an arbitrary amino acid residue and/or a bond between lysine and an arbitrary amino acid residue, an inactivated enzyme product comprising the above-mentioned enzyme inactivated by radiation irradiation, and β-alanine.

摘要翻译： 本发明提供一种在常温或更高温度下在恶劣条件下能够长时间稳定显示出高凝血性能的凝血促进剂以及容纳血液凝固促进剂的血液检查用容器。 公开了一种凝血促进剂，其包括能够在肽链中水解精氨酸与任意氨基酸残基之间的键和/或赖氨酸与任意氨基酸残基之间的键的酶，包含上述酶的失活酶产物 通过辐射照射灭活，和β-丙氨酸。

公开(公告)号：US07790409B2

公开(公告)日：2010-09-07

申请号：US11663440

申请日：2006-03-15

申请人： Masaaki Minamoto ,  Kazuhiko Shimada

发明人： Masaaki Minamoto ,  Kazuhiko Shimada

IPC分类号： C12Q1/56

CPC分类号： C12Q1/56 ,  C12N9/6429 ,  C12N9/96 ,  C12N13/00 ,  C12Y304/21005 ,  G01N33/86

摘要： The present invention provides a blood coagulation accelerator excellent under severe conditions at ordinary or higher temperatures and capable of exhibiting high blood coagulation performance stably over a long period of time, as well as a container for blood examination wherein the blood coagulation accelerator is accommodated. Disclosed is a blood coagulation accelerator comprising an enzyme capable of hydrolyzing in a peptide chain a bond between arginine and an arbitrary amino acid residue and/or a bond between lysine and an arbitrary amino acid residue, an inactivated enzyme product comprising the above-mentioned enzyme inactivated by radiation irradiation, and β-alanine.

摘要翻译： 本发明提供一种在常温或更高温度下在恶劣条件下能够长时间稳定显示出高凝血性能的凝血促进剂以及容纳血液凝固促进剂的血液检查用容器。 公开了一种凝血促进剂，其包括能够在肽链中水解精氨酸与任意氨基酸残基之间的键和/或赖氨酸与任意氨基酸残基之间的键的酶，包含上述酶的失活酶产物 通过辐射照射灭活，和 - 丙氨酸。

公开(公告)号：US08685713B2

公开(公告)日：2014-04-01

申请号：US12168767

申请日：2008-07-07

申请人： Masaaki Minamoto ,  Hironobu Isogawa

发明人： Masaaki Minamoto ,  Hironobu Isogawa

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： G01N33/4905 ,  A61L33/068 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/161 ,  B01L2300/165 ,  C08L71/02

摘要： The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether or a polyoxyalkylene glycol ether, the present invention also relates to a stopper for a blood testing bottom tube and a blood testing container.

摘要翻译： 本发明涉及血液测试有底管，其包括具有开放的一端和封闭的另一端的管状构件，以及形成在与所述管状构件上的与血液接触的至少一部分上的涂层，所述涂层为 由聚氧化烯烷基醚或聚氧亚烷基二醇醚制成，本发明还涉及一种用于血液检测底管和血液检查容器的塞子。

公开(公告)号：US07595028B2

公开(公告)日：2009-09-29

申请号：US10507740

申请日：2003-05-29

申请人： Masaaki Minamoto ,  Hironobu Isogawa

发明人： Masaaki Minamoto ,  Hironobu Isogawa

IPC分类号： B01L3/00

CPC分类号： G01N33/4905 ,  A61L33/068 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/161 ,  B01L2300/165 ,  C08L71/02

摘要： The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether and/or a polyoxyalkylene glycol ether; the present invention also relates to a stopper for a blood testing bottomed tube and a blood testing container.

摘要翻译： 本发明涉及血液测试有底管，其包括具有开放的一端和封闭的另一端的管状构件，以及形成在与所述管状构件上的与血液接触的至少一部分上的涂层，所述涂层为 由聚氧化烯烷基醚和/或聚氧亚烷基二醇醚制成; 本发明还涉及一种用于血液测试底管和血液检查容器的塞子。

公开(公告)号：US20080274540A1

公开(公告)日：2008-11-06

申请号：US12168767

申请日：2008-07-07

申请人： Masaaki Minamoto ,  Hironobu Isogawa

发明人： Masaaki Minamoto ,  Hironobu Isogawa

IPC分类号： C12M1/34

CPC分类号： G01N33/4905 ,  A61L33/068 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/161 ,  B01L2300/165 ,  C08L71/02

摘要： The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether or a polyoxyalkylene glycol ether, the present invention also relates to a stopper for a blood testing bottom tube and a blood testing container.

摘要翻译： 本发明涉及血液测试有底管，其包括具有开放的一端和封闭的另一端的管状构件，以及形成在与所述管状构件上的与血液接触的至少一部分上的涂层，所述涂层为 由聚氧化烯烷基醚或聚氧亚烷基二醇醚制成，本发明还涉及一种用于血液检测底管和血液检查容器的塞子。

公开(公告)号：US20050106071A1

公开(公告)日：2005-05-19

申请号：US10507740

申请日：2003-05-29

申请人： Masaaki Minamoto ,  Hironobu Isogawa

发明人： Masaaki Minamoto ,  Hironobu Isogawa

IPC分类号： B01L3/14 ,  G01N33/49 ,  B01L3/00

CPC分类号： G01N33/4905 ,  A61L33/068 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/161 ,  B01L2300/165 ,  C08L71/02

摘要： It is an object of the present invention to provide a blood testing bottomed tube causing no adhesion of blood clot and the like in a blood test and exerting no influence on the tested value, a stopper for a blood testing bottomed tube capable of easily plugging a blood testing bottomed tube, causing no adhesion of blood clot and the like in a blood test, exerting no influence on the tested value, and also causing no stickiness and label-peeling of a blood testing bottomed tube, and a blood testing container comprising the blood testing bottomed tube and the stopper for a blood testing bottomed tube. The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene glycol and/or a polyoxyalkylene glycol derivative, a stopper for a blood testing bottomed tube and a blood testing container.

摘要翻译： 本发明的目的是提供一种血液检测有底管，其在血液检查中不粘附血块等，对试验值不产生影响，能够容易地堵塞血液检测底管的塞子 血液检查有底管，在血液检查中不粘附血块等，对测定值不产生影响，也不引起血液检测有底管的粘性和标签剥离，以及血液检查容器，其包含 血液测试底管和用于血液检测的底管的塞子。 本发明涉及血液测试有底管，其包括具有开放的一端和封闭的另一端的管状构件，以及形成在与所述管状构件上的与血液接触的至少一部分上的涂层，所述涂层为 由聚氧亚烷基二醇和/或聚氧亚烷基二醇衍生物制成，用于血液测试底管的塞子和血液检查容器。