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    Uses of polypeptides
    5.
    发明申请
    Uses of polypeptides 审中-公开
    多肽的用途

    公开(公告)号：US20070232538A1

    公开(公告)日：2007-10-04

    申请号：US11647076

    申请日：2006-12-27

    申请人： Yoshio Matsumoto ,  Takuya Watanabe ,  Hideki Takahashi ,  Masaaki Mori

    发明人： Yoshio Matsumoto ,  Takuya Watanabe ,  Hideki Takahashi ,  Masaaki Mori

    IPC分类号： A61K48/00 ,  A61K38/17

    CPC分类号： C07D223/16 ,  A61K31/4025 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/55 ,  A61K38/00 ,  A61K48/00 ,  C07D295/13 ,  C07D471/04 ,  C07K14/47

    摘要： The present invention provides uses of a polypeptide having a ligand activity to a sensory epithelium neuropeptide-like receptor (SENR) which is a G protein-coupled receptor protein, and a DNA encoding the same. More specifically, the present invention provides an anti-attention-deficit-disorder or anti-narcolepsy agent, which comprises a polypeptide having a ligand activity for SENR or a salt thereof, as well as a method for screening compounds having an anti-attention-deficit-disorder or anti-narcolepsy activity or compounds having an anti-anxiety, anti-depression, anti-insomnia, anti-schizophrenia or anti-fear activity or salts thereof, which comprises using the above polypeptide or a precursor protein of the polypeptide or a salt thereof.

    摘要翻译： 本发明提供了作为G蛋白偶联受体蛋白质的感觉上皮神经肽样受体（SENR）具有配体活性的多肽及其编码的DNA的用途。 更具体地，本发明提供了包含对SENR具有配体活性的多肽或其盐的抗注意力缺陷障碍或抗发作性睡病剂，以及用于筛选具有抗注意力缺陷型或抗发作性睡病的化合物的方法， 包括使用上述多肽或该多肽的前体蛋白，或者，具有抗焦虑，抗抑郁，抗失眠，抗精神分裂症或抗恐惧活性的化合物或抗发作性睡病活动， 其盐。

    Polypeptides and use thereof
    7.
    发明授权
    Polypeptides and use thereof 失效
    多肽及其用途

    公开(公告)号：US5801147A

    公开(公告)日：1998-09-01

    申请号：US766725

    申请日：1996-12-13

    申请人： Chieko Kitada ,  Takuya Watanabe

    发明人： Chieko Kitada ,  Takuya Watanabe

    IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K14/575 ,  C07K14/00

    CPC分类号： C07K1/006 ,  C07K14/57563 ,  A61K38/00

    摘要： Disclosed are (1) a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof: His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO:13 (I) wherein X is hydrogen atom; or a lower alkyl group which may be substituted with a member selected from the group consisting of hydroxy group, substituted or unsubstituted amino group, carboxyl group, carbamoyl group, and substituted or unsubstituted aromatic group; and Y is one of amino acids or peptides consisting of 1 to 16 amino acid residues counted from the N-terminal side of Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys SEQ ID NO:20, and (2) a pharmaceutical composition comprising a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof, which has remarkable c-AMP activity and is useful as a nerve activating agent.

    摘要翻译： 公开了（1）式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐：His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr -Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO：13（I）其中X是氢原子; 或可以被选自羟基，取代或未取代的氨基，羧基，氨基甲酰基和取代或未取代的芳基的成员取代的低级烷基; Y是从Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val的N-末端计数的1至16个氨基酸残基组成的氨基酸或肽之一 -Lys-Asn-Lys SEQ ID NO：20，和（2）包含由式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐的药物组合物，其具有显着的c-AMP活性并且是有用的 作为神经活化剂。

    G protein-coupled receptor protein, its DNA and ligand thereof
    9.
    发明授权
    G protein-coupled receptor protein, its DNA and ligand thereof 失效
    G蛋白偶联受体蛋白，其DNA及其配体

    公开(公告)号：US07192723B2

    公开(公告)日：2007-03-20

    申请号：US10719587

    申请日：2003-11-21

    申请人： Takuya Watanabe ,  Kuniko Kikuchi ,  Yasuko Terao ,  Yasushi Shintani ,  Shuji Hinuma ,  Shoji Fukusumi ,  Ryo Fujii ,  Masaki Hosoya ,  Chieko Kitada

    发明人： Takuya Watanabe ,  Kuniko Kikuchi ,  Yasuko Terao ,  Yasushi Shintani ,  Shuji Hinuma ,  Shoji Fukusumi ,  Ryo Fujii ,  Masaki Hosoya ,  Chieko Kitada

    IPC分类号： C07K7/08 ,  C07K14/47 ,  G01N33/566

    CPC分类号： C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

    摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

    摘要翻译： 本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如 作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤 肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。