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33 条记录 (耗时 0.046 秒)

    Novel physiologically active peptide and use thereof
    4.
    发明申请
    Novel physiologically active peptide and use thereof 失效
    新型生理活性肽及其用途

    公开(公告)号：US20060088915A1

    公开(公告)日：2006-04-27

    申请号：US11304129

    申请日：2005-12-15

    申请人： Tetsuya Ohtaki ,  Yasushi Masuda ,  Yoshihiro Takatsu ,  Takuya Watanabe ,  Yasuko Terao ,  Yasushi Shintani ,  Syuji Hinuma

    发明人： Tetsuya Ohtaki ,  Yasushi Masuda ,  Yoshihiro Takatsu ,  Takuya Watanabe ,  Yasuko Terao ,  Yasushi Shintani ,  Syuji Hinuma

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N33/74 ,  G01N2500/02

    摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.

    摘要翻译： 本发明意图提供一种新的肽及其用途。 更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或 其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。 此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

    Physiologically active peptide and use thereof
    5.
    发明授权
    Physiologically active peptide and use thereof 失效
    生理活性肽及其用途

    公开(公告)号：US07045299B2

    公开(公告)日：2006-05-16

    申请号：US10333192

    申请日：2001-07-17

    申请人： Tetsuya Ohtaki ,  Yasushi Masuda ,  Yoshihiro Takatsu ,  Takuya Watanabe ,  Yasuko Terao ,  Yasushi Shintani

    发明人： Tetsuya Ohtaki ,  Yasushi Masuda ,  Yoshihiro Takatsu ,  Takuya Watanabe ,  Yasuko Terao ,  Yasushi Shintani

    IPC分类号： G01N33/53 ,  C12P2/06 ,  C07K14/00 ,  C07K2/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N33/74 ,  G01N2500/02

    摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.

    摘要翻译： 本发明意图提供一种新的肽及其用途。 更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或 其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。 此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

    Isolated physiologically active peptide and use thereof
    6.
    发明授权
    Isolated physiologically active peptide and use thereof 失效
    分离的生理活性肽及其用途

    公开(公告)号：US07419956B2

    公开(公告)日：2008-09-02

    申请号：US11304129

    申请日：2005-12-15

    申请人： Tetsuya Ohtaki ,  Yasushi Masuda ,  Yoshihiro Takatsu ,  Takuya Watanabe ,  Yasuko Terao ,  Yasushi Shintani ,  Syuji Hinuma

    发明人： Tetsuya Ohtaki ,  Yasushi Masuda ,  Yoshihiro Takatsu ,  Takuya Watanabe ,  Yasuko Terao ,  Yasushi Shintani ,  Syuji Hinuma

    IPC分类号： A61K38/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N33/74 ,  G01N2500/02

    摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.

    摘要翻译： 本发明意图提供一种新的肽及其用途。 更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或 其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。 此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

    Gonadal function improving agents
    9.
    发明申请
    Gonadal function improving agents 有权
    性腺功能改善剂

    公开(公告)号：US20060287227A1

    公开(公告)日：2006-12-21

    申请号：US10547974

    申请日：2004-03-11

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K48/00 ,  A61K38/24

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

    Physiologically active peptide and its use
    10.
    发明授权
    Physiologically active peptide and its use 失效
    生理活性肽及其用途

    公开(公告)号：US07064181B1

    公开(公告)日：2006-06-20

    申请号：US09646078

    申请日：1999-03-24

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： C07K14/00

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, a appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。