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4 条记录 (耗时 0.028 秒)

    Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
    1.
    发明授权
    Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents 失效
    唑（thia）唑烷化合物，其制备方法和抗炎剂

    公开(公告)号：US07189751B2

    公开(公告)日：2007-03-13

    申请号：US10482231

    申请日：2002-06-25

    申请人： Masae Takagi ,  Tadayuki Nishibe ,  Keiichi Ishimitsu

    发明人： Masae Takagi ,  Tadayuki Nishibe ,  Keiichi Ishimitsu

    IPC分类号： A61K31/42 ,  C07D263/02

    CPC分类号： C07D263/10 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  C07D263/14 ,  C07D263/16 ,  C07D277/10 ,  C07D277/12 ,  C07D277/16 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

    摘要： The present invention provides medicinal compositions characterized by comprising as the active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; [wherein X represents oxygen or sulfur; R1 represents e.g., C1-4 alkyl, phenyl optionally substituted, etc.; Q1 represents spacer consisted of 0 to 3 carbon atoms; R2 represents, e.g., phenyl optionally substituted; R3 represents, e.g., hydrogen, C1-4 alkyl, or a group represented by the following formulae; —CONH—R6; R4 and R5 represent e.g., nitro, cyano, C1-4 alkylcarbonyl, respectively]; in particular, medicine which is useful as therapeutic and/or protective drugs for inflammatory diseases and/or allergic diseases by improving sick conditions accompanied with the stimulated phospholipase A(2) activity.

    摘要翻译： 本发明提供药物组合物，其特征在于包含作为活性成分的由式[I]表示的化合物或其药学上可接受的复合物; [式中，X表示氧或硫; R 1表示例如C 1-4烷基，任选取代的苯基等; Q 1表示由0至3个碳原子组成的间隔基; R 2表示例如任选取代的苯基; R 3表示例如氢，C 1-4烷基或由下式表示的基团; -CONH-R 6; R 4和R 5分别表示硝基，氰基，C 1-4烷基羰基]; 特别是通过改善伴随刺激的磷脂酶A（2）活性的病症，可用作炎性疾病和/或过敏性疾病的治疗和/或保护性药物的药物。

    Phenylazole compounds, process for producing the same and drugs for hyperlipemia
    4.
    发明授权
    Phenylazole compounds, process for producing the same and drugs for hyperlipemia 失效
    苯唑化合物，其制备方法和高脂血症药物

    公开(公告)号：US06342516B1

    公开(公告)日：2002-01-29

    申请号：US09744786

    申请日：2001-01-26

    申请人： Nobuhiro Umeda ,  Nobuo Mochizuki ,  Seiichi Uchida ,  Tadayuki Nishibe ,  Hirokazu Yamada ,  Kunihito Ito ,  Hiromi Horikoshi

    发明人： Nobuhiro Umeda ,  Nobuo Mochizuki ,  Seiichi Uchida ,  Tadayuki Nishibe ,  Hirokazu Yamada ,  Kunihito Ito ,  Hiromi Horikoshi

    IPC分类号： C07D23358

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/12

    摘要： Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A represents imidazolyl, pyrazolyl, etc.; B represents (1a) or (1b) (wherein R2 and R3 represent each hydrogen, C1-6 alkyl, etc; and k is 0 or an integer of 1 to 15); Y represents O, S, a bond, etc.; and Z represents an optionally substituted and saturated or unsaturated heterocycle containing 1 to 4 N, O or S atoms. Among all, compounds wherein Z is substituted chroman-2-yl, 2,3-dihydrobenzofuran-2-yl, etc. have an effect of inhibiting the formation of lipid peroxides too.

    摘要翻译： 由通式（1）表示的苯唑化合物或其药学上可接受的盐和含有这些化合物作为活性成分的高脂血症药物，其中A表示咪唑基，吡唑基等; B表示（1a）或（1b）（其中R2和R3表示各个氢，C1-6烷基等;和k为0或1〜15的整数）; Y表示O，S，键等; Z表示任选取代的饱和或不饱和的含有1至4个N，O或S原子的杂环。 其中Z为取代苯并二氢吡喃-2-基，2,3-二氢苯并呋喃-2-基等的化合物也具有抑制脂质过氧化物形成的作用。