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    S/O Type Pharmaceutical Preparation and Method for Producing the Same
    1.
    发明申请
    S/O Type Pharmaceutical Preparation and Method for Producing the Same 审中-公开
    S / O型药物制备及其制备方法

    公开(公告)号：US20070207138A1

    公开(公告)日：2007-09-06

    申请号：US11547090

    申请日：2005-03-31

    申请人： Masahiro Goto ,  Noriho Kamiya ,  Aklhiko Hirata ,  Takeru Fujii

    发明人： Masahiro Goto ,  Noriho Kamiya ,  Aklhiko Hirata ,  Takeru Fujii

    IPC分类号： A61K9/20 ,  A61K38/46 ,  A61K38/47 ,  A61K31/727 ,  A61K31/405 ,  A61K31/192

    CPC分类号： A61K9/167 ,  A61K9/10 ,  A61K31/196 ,  A61K31/405

    摘要： The present invention provides a pharmaceutical preparation that significantly reduces leakage of a low-molecule medicine in a strong acidic environment, while allowing release of the low-molecule medicine in the enteric canal or the like which is in a weak acidic to neutral environment. The S/O type pharmaceutical preparation of the present invention is characterized in comprising a medicine-containing complex dissolved or dispersed in an oil phase, wherein the complex contains a mixture and a surfactant, the mixture is covered by the surfactant, and the mixture contains a hydrophilic low molecule medicine, and a hydrophilic medicine-leakage-suppressive protein and/or a medicine-leakage-suppressive polysaccharide.

    摘要翻译： 本发明提供了一种药物制剂，其在强酸性环境中显着降低低分子药物的泄漏，同时允许在弱酸性至中性环境中释放肠道等中的低分子药物。 本发明的S / O型药物组合物的特征在于，含有溶解或分散在油相中的含药复合物，其中复合物含有混合物和表面活性剂，混合物被表面活性剂覆盖，混合物含 亲水性低分子药物和亲水性药物泄漏抑制蛋白质和/或药物渗漏抑制性多糖。

    S/O TYPE TRANSDERMAL IMMUNIZING AGENT
    2.
    发明申请
    S/O TYPE TRANSDERMAL IMMUNIZING AGENT 审中-公开
    S / O型超声波灭菌剂

    公开(公告)号：US20110159035A1

    公开(公告)日：2011-06-30

    申请号：US13055989

    申请日：2008-08-01

    申请人： Masahiro Goto ,  Noriho Kamiya ,  Akihiko Hirata ,  Takeru Fujii

    发明人： Masahiro Goto ,  Noriho Kamiya ,  Akihiko Hirata ,  Takeru Fujii

    IPC分类号： A61K39/02 ,  A61K39/00 ,  A61K39/12 ,  A61P37/04

    CPC分类号： A61K39/39 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/113 ,  A61K2039/54 ,  A61K2039/55555

    摘要： It is an objective of the present invention to provide a non-invasive transdermal immunizing technology by which inflammation and lump do not appear at the skin unlike conventional transdermal immunizing methods with subcutaneous administration and the development amount of antibody in serum is increased. The S/O type transdermal immunizing agent according to the present invention comprises an antigen-surfactant complex and an oil phase; wherein the antigen is covered with the surfactant in the complex; the complex is in a solid state; and the complex is dissolved or dispersed in the oil phase.

    摘要翻译： 本发明的目的是提供一种非侵入性透皮免疫技术，通过皮下给药，常规的经皮免疫方法，炎症和肿块不会出现在皮肤上，并且血清中抗体的显影量增加。 根据本发明的S / O型透皮免疫剂包含抗原 - 表面活性剂复合物和油相; 其中所述抗原被所述复合物中的表面活性剂覆盖; 复合体处于固体状态; 并且复合物溶解或分散在油相中。

    S/O type external preparation
    3.
    发明申请
    S/O type external preparation 审中-公开
    S / O型外用剂

    公开(公告)号：US20090238846A1

    公开(公告)日：2009-09-24

    申请号：US11661292

    申请日：2005-08-31

    申请人： Takeru Fujii ,  Akihiko Hirata ,  Masahiro Goto ,  Noriho Kamiya

    发明人： Takeru Fujii ,  Akihiko Hirata ,  Masahiro Goto ,  Noriho Kamiya

    IPC分类号： A61K9/00 ,  A61K31/196

    CPC分类号： A61K9/0014 ,  A61K9/113 ,  A61K31/196 ,  A61K31/405

    摘要： The present invention provides an external preparation which can improve a skin permeability of a hydrophilic medicine such as NSAID so that the medicine can act directly on a diseased area without passing through gastrointestinal tract or mucosa. The S/O type external preparation external preparation excellent in percutaneous absorbability of the present invention comprises a medicine-containing complex dissolved or dispersed in an oil phase, wherein the complex contains a hydrophilic medicine covered with a surfactant and is in a form of a solid.

    摘要翻译： 本发明提供一种能够改善亲水性药物如NSAID的皮肤渗透性的外用制剂，使得药物可以直接作用于患病区域而不通过胃肠道或粘膜。 本发明的经皮吸收性优异的S / O型外用剂组合物含有溶解或分散在油相中的药物复合物，其中复合物含有用表面活性剂覆盖的亲水性药物，为固体形式 。

    Peptide having an affinity for gp120
    4.
    发明授权
    Peptide having an affinity for gp120 失效
    对gp120具有亲和力的肽

    公开(公告)号：US07291337B2

    公开(公告)日：2007-11-06

    申请号：US10909310

    申请日：2004-08-03

    申请人： Takeru Fujii ,  Hideakira Yokoyama ,  Hidetoshi Hamamoto

    发明人： Takeru Fujii ,  Hideakira Yokoyama ,  Hidetoshi Hamamoto

    IPC分类号： A61K39/15

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/005 ,  C12N2740/16122

    摘要： The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R(SEQ ID No. 1) (in the formula, H means hydrogen, A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue, A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue, A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue, A4 is alanine, tryptophan, or glycine residue, A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue, R is OH derived from carboxyl group or NH2 derived from acid amide group). The above peptide has an affinity to gp120 of the HIV envelope protein and is superior in stability.

    摘要翻译： 本发明中的肽是对由式（1）表示的gp120具有亲和性的肽：H-A1-A2-A3-A4-A5-R（SEQ ID No.1）（式中，H表示氢，A1为 天冬氨酸，赖氨酸，缬氨酸，谷氨酸，甘氨酸，天冬酰胺或酪氨酸残基，A2是缬氨酸，天冬氨酸，色氨酸，赖氨酸，苯丙氨酸，异亮氨酸，亮氨酸或酪氨酸残基，A3是赖氨酸，缬氨酸，天冬氨酸，精氨酸， 丙氨酸或色氨酸残基，A4是丙氨酸，色氨酸或甘氨酸残基，A5是甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，甲硫氨酸，天冬酰胺，谷氨酰胺，组氨酸，赖氨酸，精氨酸，苯丙氨酸，色氨酸， 或酪氨酸残基，R为衍生自酰胺基团的羧基或NH 2的OH）。 上述肽对HIV包膜蛋白的gp120具有亲和力，并且稳定性优异。

    Liquid matrix undergoing phase transfer in vivo and liquid oral preparations
    5.
    发明申请
    Liquid matrix undergoing phase transfer in vivo and liquid oral preparations 审中-公开
    液体基质在体内进行相转移和液体口服制剂

    公开(公告)号：US20050089577A1

    公开(公告)日：2005-04-28

    申请号：US10506512

    申请日：2003-03-03

    申请人： Hideakira Yokoyama ,  Akihiko Hirata ,  Hidetoshi Hamamoto ,  Keiko Yamasaki ,  Takeru Fujii

    发明人： Hideakira Yokoyama ,  Akihiko Hirata ,  Hidetoshi Hamamoto ,  Keiko Yamasaki ,  Takeru Fujii

    IPC分类号： A61K9/00 ,  A61K31/43 ,  A61K31/496 ,  A61K31/545 ,  A61K31/65 ,  A61K31/7048 ,  A61K47/04 ,  A61K9/14

    CPC分类号： A61K9/0095 ,  A61K31/43 ,  A61K31/496 ,  A61K31/545 ,  A61K31/65 ,  A61K31/7048

    摘要： It is intended to provide a liquid matrix for medicinal use in which medicine can be easily solubilized, dispersed or suspended and which can be easily swallowed because of being liquid, has favorable working properties in sterilization and so on and a high stability, also exhibits an effect of masking bitterness, and gels in vivo so as to control the release speed of the medicine, and liquid oral preparations using the same. Namely, a liquid matrix which is a liquid assistant for facilitating swallowing medicine characterized in comprising a water-soluble polymer gelling under acidic conditions, and the breaking stress of the gel is about 3.00×103 N/m2 or more. Liquid oral preparations have favorable slow release properties even though being a liquid.

    摘要翻译： 本发明提供一种医药用液体基质，其中药物易于溶解，分散或悬浮，并且由于液体容易吞咽，在消毒等中具有良好的加工性能和高稳定性，还表现出 掩蔽苦味的效果和体内凝胶，以控制药物的释放速度，以及使用其的液体口服制剂。 即，作为促进吞咽药物的液体助剂的液体基质，其特征在于在酸性条件下含有水溶性聚合物胶凝，凝胶的断裂应力为约3.00×10 3 N / SUP> 2以上。 液体口服制剂即使是液体也具有良好的缓释特性。

    COMPOSITE PRODUCT OF LOW-SOLUBILITY DRUG AND SURFACTANT, AND PROCESS FOR PRODUCTION THEREOF
    6.
    发明申请
    COMPOSITE PRODUCT OF LOW-SOLUBILITY DRUG AND SURFACTANT, AND PROCESS FOR PRODUCTION THEREOF 审中-公开
    低溶解性药物和表面活性剂的复合产品及其生产方法

    公开(公告)号：US20100298447A1

    公开(公告)日：2010-11-25

    申请号：US12740590

    申请日：2008-10-29

    申请人： Takeru Fujii ,  Eiji Hayakawa ,  Akihiko Hirata

    发明人： Takeru Fujii ,  Eiji Hayakawa ,  Akihiko Hirata

    IPC分类号： A61K47/44 ,  A61P31/12 ,  A61P19/02

    CPC分类号： A61K9/107 ,  A61K9/145

    摘要： This invention is intended to improve the solubility and permeability of low-solubility drugs, including drugs hardly soluble in water, classified as Class 2 or 4 in accordance with BCS by modifying such drugs into S/W, S/O, or S/O/W preparations. The S/W, S/O, or S/O/W preparations of low-solubility drugs of this invention are prepared by a method for preparing a composite of a low-solubility drug and surfactant by introducing air or nonflammable gas into the gas phase in the upper portion of a liquid level of the dispersion, dissolution, and emulsification tanks, respectively, at a pressure of 1 to 10 atm.

    摘要翻译： 本发明旨在通过将这些药物改性成S / W，S / O或S / O来改善低溶解性药物（包括难溶于水的溶解性和渗透性），按照BCS分类为2类或4类 / W准备。 本发明的低溶解度药物的S / W，S / O或S / O / W制剂是通过将空气或不可燃气体引入气体中制备低溶解度药物和表面活性剂的复合物的方法制备的 分别在分散体，溶解和乳化罐的液面的上部相分别以1至10个大气压的压力。

    Biguanide drug-containing jelly preparation
    7.
    发明申请
    Biguanide drug-containing jelly preparation 审中-公开
    双胍药物含果冻制剂

    公开(公告)号：US20070053939A1

    公开(公告)日：2007-03-08

    申请号：US10576209

    申请日：2004-10-15

    申请人： Hideakira Yokoyama ,  Akihiko Hirata ,  Hidetoshi Hamamoto ,  Masaki Ishibashi ,  Keiko Yamasaki ,  Takeru Fujii

    发明人： Hideakira Yokoyama ,  Akihiko Hirata ,  Hidetoshi Hamamoto ,  Masaki Ishibashi ,  Keiko Yamasaki ,  Takeru Fujii

    IPC分类号： A61K31/155 ,  A61K9/00

    CPC分类号： A61K47/02 ,  A61K9/0056 ,  A61K31/155 ,  A61K47/36

    摘要： The invention provides a biguanide drug-containing jelly preparation of which discomfort upon administration is decreased by the control of its harshness or bitterness. In addition, the preparation has stability and excellent ability for releasing a drug in the digestive tract. The biguanide drug-containing jelly preparation of the invention is characterized by comprising a biguanide drug, an inorganic acid, and a water-soluble polymer. The jelly preparation of the invention is excellent in both stability and ability for releasing a drug, which are usually incompatible characters, particularly by the action of the inorganic acid.

    摘要翻译： 本发明提供了一种含双胍类药物的果冻制剂，其通过控制其粗糙度或苦味来降低给药后的不适。 另外，该制剂具有在消化道中释放药物的稳定性和极好的能力。 本发明的双胍药物凝胶制剂的特征在于包含双胍药物，无机酸和水溶性聚合物。 本发明的果冻制剂在稳定性和释放药物的能力方面都是优异的，这通常是不相容的特征，特别是通过无机酸的作用。

    SASH WINDOW ASSEMBLY
    10.
    发明申请
    SASH WINDOW ASSEMBLY 审中-公开
    SASH WINDOW装配

    公开(公告)号：US20080202046A1

    公开(公告)日：2008-08-28

    申请号：US12027354

    申请日：2008-02-07

    申请人： Takeru Fujii

    发明人： Takeru Fujii

    IPC分类号： E06B3/96 ,  E06B1/04

    CPC分类号： E06B3/5821

    摘要： A sash window assembly includes a face material provided in an opening section open to an indoor and outdoor side, a frame section provided within the opening section, and beads attached to the frame section with the ends of the beads angled and butted against one another, the beads for pressing upon the face material from one of the indoor and outdoor directions, wherein each of the beads includes a first engaging section and a second engaging section, the first engaging section engaging with the frame section at a front-side in a movement direction, the second engaging section engaging with the frame further toward a rear-side in the movement direction than the first engaging section, when the bead is moved in the movement direction along a depth direction; the frame section includes a first engaging projection that engages with the first engaging section, a second engaging projection that engages with the second engaging section, and a recess provided between the first engaging projection and the second engaging projection, the recess being recessed toward an inner side of the frame section; and each of the beads is moved with the first engaging section of each bead inserted into the recess, the first engaging section being engaged with the first engaging projection in a state where the bead is tilted so that the second engaging section moves away from the frame section, the second engaging section being engaged with the second engaging projection by rotating the bead in a direction that brings the second engaging section closer to the frame section.

    摘要翻译： 窗扇组件包括：设置在开放室内和室外侧的开口部分中的面材，设置在开口部分内的框架部分，以及附接到框架部分的小珠，其两端彼此成角度对接， 用于从室内和室外的一个方向按压在面材上的珠，其中每个珠包括第一接合部和第二接合部，第一接合部在运动的前侧与框架部接合 所述第二接合部在所述凸缘沿着深度方向的移动方向移动时，与所述框架进一步朝向所述移动方向的后侧与所述第一接合部接合; 框架部分包括与第一接合部分接合的第一接合突起，与第二接合部分接合的第二接合突起，以及设置在第一接合突起和第二接合突起之间的凹部，凹部朝向内部 框架部分的侧面; 并且每个珠粒随着每个珠粒的第一接合部分插入凹部而移动，第一接合部分在第一接合突起处于凸起倾斜的状态下与第二接合部分从框架移开 所述第二接合部通过使所述胎圈沿使所述第二接合部更靠近所述框架部的方向旋转而与所述第二接合突起接合。