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11 条记录 (耗时 0.021 秒)

    ENZYME SUBSTRATE FOR LABELING OF PROTEIN
    1.
    发明申请
    ENZYME SUBSTRATE FOR LABELING OF PROTEIN 审中-公开
    用于标记蛋白质的酶基质

    公开(公告)号：US20110184147A1

    公开(公告)日：2011-07-28

    申请号：US13001929

    申请日：2009-07-03

    申请人： Noriho Kamiya ,  Masahiro Goto ,  Hiroki Abe

    发明人： Noriho Kamiya ,  Masahiro Goto ,  Hiroki Abe

    IPC分类号： C07K5/08 ,  C07K5/06 ,  C07K19/00 ,  C12P21/02

    CPC分类号： C07K1/13 ,  C07K5/06113 ,  G01N33/535

    摘要： The present invention provides a substrate of TGase represented by (fluorescent group)-(linker)-(a portion containing a Gln residue capable of recognition by transglutaminase (TGase))-R, wherein the fluorescent group is fluorescein isothiocyanate (FITC), Texas Red (TE) or dansyl (Dns) or a group derived therefrom; the linker is a group represented by —NH—(CH2)n—CO— (n is an integer of 1 to 6); the portion containing a Gln residue capable of recognition by TGase is a group derived from a peptide selected from among QG and the like; and R is a hydroxyl group, or biotin, nucleic acid, azide, alkyne, maleimide or cyclopentadiene, or a group derived therefrom.

    摘要翻译： 本发明提供由（荧光基团） - （接头） - （含有能够被转谷氨酰胺酶（TGase）识别的Gln残基的部分）-R表示的TGase的底物，其中荧光基团是异硫氰酸荧光素（FITC），得克萨斯 红（TE）或丹酰基（Dns）或衍生自其的基团; 接头是由-NH-（CH 2）n -CO-（n为1至6的整数）表示的基团。 含有能够通过TGase识别的Gln残基的部分是衍生自选自QG等的肽的基团; R为羟基，或生物素，核酸，叠氮化物，炔，马来酰亚胺或环戊二烯，或由其衍生的基团。

    S/O TYPE TRANSDERMAL IMMUNIZING AGENT
    4.
    发明申请
    S/O TYPE TRANSDERMAL IMMUNIZING AGENT 审中-公开
    S / O型超声波灭菌剂

    公开(公告)号：US20110159035A1

    公开(公告)日：2011-06-30

    申请号：US13055989

    申请日：2008-08-01

    申请人： Masahiro Goto ,  Noriho Kamiya ,  Akihiko Hirata ,  Takeru Fujii

    发明人： Masahiro Goto ,  Noriho Kamiya ,  Akihiko Hirata ,  Takeru Fujii

    IPC分类号： A61K39/02 ,  A61K39/00 ,  A61K39/12 ,  A61P37/04

    CPC分类号： A61K39/39 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/113 ,  A61K2039/54 ,  A61K2039/55555

    摘要： It is an objective of the present invention to provide a non-invasive transdermal immunizing technology by which inflammation and lump do not appear at the skin unlike conventional transdermal immunizing methods with subcutaneous administration and the development amount of antibody in serum is increased. The S/O type transdermal immunizing agent according to the present invention comprises an antigen-surfactant complex and an oil phase; wherein the antigen is covered with the surfactant in the complex; the complex is in a solid state; and the complex is dissolved or dispersed in the oil phase.

    摘要翻译： 本发明的目的是提供一种非侵入性透皮免疫技术，通过皮下给药，常规的经皮免疫方法，炎症和肿块不会出现在皮肤上，并且血清中抗体的显影量增加。 根据本发明的S / O型透皮免疫剂包含抗原 - 表面活性剂复合物和油相; 其中所述抗原被所述复合物中的表面活性剂覆盖; 复合体处于固体状态; 并且复合物溶解或分散在油相中。

    S/O type external preparation
    5.
    发明申请
    S/O type external preparation 审中-公开
    S / O型外用剂

    公开(公告)号：US20090238846A1

    公开(公告)日：2009-09-24

    申请号：US11661292

    申请日：2005-08-31

    申请人： Takeru Fujii ,  Akihiko Hirata ,  Masahiro Goto ,  Noriho Kamiya

    发明人： Takeru Fujii ,  Akihiko Hirata ,  Masahiro Goto ,  Noriho Kamiya

    IPC分类号： A61K9/00 ,  A61K31/196

    CPC分类号： A61K9/0014 ,  A61K9/113 ,  A61K31/196 ,  A61K31/405

    摘要： The present invention provides an external preparation which can improve a skin permeability of a hydrophilic medicine such as NSAID so that the medicine can act directly on a diseased area without passing through gastrointestinal tract or mucosa. The S/O type external preparation external preparation excellent in percutaneous absorbability of the present invention comprises a medicine-containing complex dissolved or dispersed in an oil phase, wherein the complex contains a hydrophilic medicine covered with a surfactant and is in a form of a solid.

    摘要翻译： 本发明提供一种能够改善亲水性药物如NSAID的皮肤渗透性的外用制剂，使得药物可以直接作用于患病区域而不通过胃肠道或粘膜。 本发明的经皮吸收性优异的S / O型外用剂组合物含有溶解或分散在油相中的药物复合物，其中复合物含有用表面活性剂覆盖的亲水性药物，为固体形式 。

    S/O Type Pharmaceutical Preparation and Method for Producing the Same
    10.
    发明申请
    S/O Type Pharmaceutical Preparation and Method for Producing the Same 审中-公开
    S / O型药物制备及其制备方法

    公开(公告)号：US20070207138A1

    公开(公告)日：2007-09-06

    申请号：US11547090

    申请日：2005-03-31

    申请人： Masahiro Goto ,  Noriho Kamiya ,  Aklhiko Hirata ,  Takeru Fujii

    发明人： Masahiro Goto ,  Noriho Kamiya ,  Aklhiko Hirata ,  Takeru Fujii

    IPC分类号： A61K9/20 ,  A61K38/46 ,  A61K38/47 ,  A61K31/727 ,  A61K31/405 ,  A61K31/192

    CPC分类号： A61K9/167 ,  A61K9/10 ,  A61K31/196 ,  A61K31/405

    摘要： The present invention provides a pharmaceutical preparation that significantly reduces leakage of a low-molecule medicine in a strong acidic environment, while allowing release of the low-molecule medicine in the enteric canal or the like which is in a weak acidic to neutral environment. The S/O type pharmaceutical preparation of the present invention is characterized in comprising a medicine-containing complex dissolved or dispersed in an oil phase, wherein the complex contains a mixture and a surfactant, the mixture is covered by the surfactant, and the mixture contains a hydrophilic low molecule medicine, and a hydrophilic medicine-leakage-suppressive protein and/or a medicine-leakage-suppressive polysaccharide.

    摘要翻译： 本发明提供了一种药物制剂，其在强酸性环境中显着降低低分子药物的泄漏，同时允许在弱酸性至中性环境中释放肠道等中的低分子药物。 本发明的S / O型药物组合物的特征在于，含有溶解或分散在油相中的含药复合物，其中复合物含有混合物和表面活性剂，混合物被表面活性剂覆盖，混合物含 亲水性低分子药物和亲水性药物泄漏抑制蛋白质和/或药物渗漏抑制性多糖。