摘要:
2-Oxo-1,2-dihydro-1,8-naphthyridine derivatives characterized by bearing a specific substituent, —X—R6, at the 3-position and a cyclic substituent, R5, at the 4-position; or salts thereof. The derivatives and the salts are useful as drugs, particularly preventive or therapeutic agents for respiratory diseases related to PDE IV.
摘要:
The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein R1, R2: hydrogen, a halogen, a lower alkyl, a lower alkoxy, or the like, R3, R4: hydrogen, a (substituted) lower alkyl, a halogen, or the like, R5: hydrogen, a lower alkyl, a lower alkoxycarbonyl, or the like, and n: 0 or 1).
摘要:
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要:
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要:
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要:
A flat acoustic transducer (100) includes a permanent magnet (10) and a magnetic member (20), which are arranged adjacent to each other with a predetermined interval, a flat vibrating membrane (30), provided facing the permanent magnet (10) and the magnetic member (20), and at least one coil (40), fixed to the vibrating membrane (30). In the flat acoustic transducer (100), an electrical signal is applied to the coil (40), to obtain vibration force (F) on the vibrating membrane (30) by way of a magnetic flux Φ generated between a magnetic pole face (12) of the permanent magnet (10) and the magnetic member (20), a step (50) is provided between the magnetic pole face (12) and the upper face (22) of the magnetic member (20), while at least part of a winding (42) of the coil (40) at the time of no application of an electrical signal is arranged inside the step (50).
摘要:
An information processing apparatus includes a storage unit that stores a first user identifier that identifies respective users in the information processing apparatus, and plural second user identifiers stored in respective authentication apparatuses and identify the users in each authentication apparatus, so as to correspond with each other; a first authentication request unit that transmits authentication information input by a user to at least one of the authentication apparatuses and requests authentication of the user; a first user identifier acquisition unit that, when authentication of the user has been successful, acquires the second user identifier of that user stored in that authentication apparatus; and a use allowing unit that specifies the first user identifier stored in the storage unit corresponding with the second user identifier acquired by the first user identifier acquisition unit, and allows the user identified by the specified first user identifier to use the information processing apparatus.
摘要:
A seat reclining apparatus for an automotive vehicle which employs a differential transmission mechanism in which an inner gear and an outer gear having slightly smaller number of teeth than the inner gear are supported in their partly engaged states by a rotation shaft part and an eccentric shaft which is eccentric with respect to the rotation shaft, wherein the eccentric shaft part includes two wedge plates sandwichingly inserted between a bearing ring inner peripheral surface of the outer gear and a bearing cylinder outer peripheral surface of the inner gear when the seatback is in the fixed position, a spring rod for biasing the two wedge plates in opposite peripheral directions, and an operation piece part for releasing the sandwichingly inserting states of the wedge plates when the seatback is in the fixed position by being rotated together with the rotation shaft and rotated together with the wedge plates when the seatback is in an adjusting position, each of the wedge plates being in a crescent shape including an arcuate outer surface part which is slid into contact with the inner peripheral surface of the bearing ring and an arcuate inner surface part which is slid into contact with the outer peripheral surface of the bearing cylinder when the seatback is in the adjusting position, and each of the wedge plates being approximately 180 degrees or more in arcuate angle which is formed between the arcuate outer surface part and the arcuate inner surface part, the two wedge plates being arranged in an overlapping relation in the axial direction of the rotation shaft.
摘要:
1,8-Naphthyridine derivatives represented by the following general formula (I), salts thereof, hydrates thereof and solvates thereof. ##STR1## They have an activity to inhibit type IV phosphodiesterase and are useful as agents for the prevention and treatment of respiratory diseases, inflammatory diseases accompanying organ transplantation, systemic or local arthropathy, proliferative diseases, micturition-related diseases and diseases in which tumor necrosis factor (TNF) and other cytokine (IL-1, IL-6 or the like) are concerned.
摘要:
This invention relates to compounds (I) or pharmaceutically acceptable salts thereof, having a function to inhibit type IV phosphodiesterase (PDE) ##STR1## [X: an oxygen atom or a sulfur atom, R.sup.1 : a lower alkyl group, a cycloalkyl-lower alkyl group or a cycloalkyl group,R.sup.2 : a hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxy-lower alkyl group, a mercapto-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkylthio-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a lower alkanoylthio-lower alkyl group, a lower alkanoyl-lower alkyl group, a hydroxyimino-lower alkyl group, a lower alkoxyimino-lower alkyl group, a cycloalkyl group, an aryl group or a lower alkanoyl group,R.sup.3 : a hydrogen atom, a halogen atom or a lower alkyl group,R.sup.4 : a hydrogen atom or a lower alkyl group,R.sup.5 : a cycloalkyl group; a naphthyl group substituted; a five- or six-membered monocyclic hetero ring group having 1 to 4 hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom; or a group represented by the formula ##STR2## amd F.sup.6 : a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxyl group, a lower alkoxy group, a cyano group or a nitro group].