利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

189 条记录 (耗时 0.035 秒)

    Nitrogen-containing heterocyclic compound
    3.
    发明申请
    Nitrogen-containing heterocyclic compound 审中-公开
    含氮杂环化合物

    公开(公告)号：US20050096322A1

    公开(公告)日：2005-05-05

    申请号：US10505939

    申请日：2003-02-27

    申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    IPC分类号： A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503

    CPC分类号： C07D487/04

    摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

    摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

    Nitrogen-containing heterocyclic compound
    4.
    发明授权
    Nitrogen-containing heterocyclic compound 失效
    含氮杂环化合物

    公开(公告)号：US07173033B2

    公开(公告)日：2007-02-06

    申请号：US11190859

    申请日：2005-07-28

    申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P19/08

    CPC分类号： C07D487/04

    摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention.Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

    摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

    Bearing structure using resin bush
    9.
    发明授权
    Bearing structure using resin bush 有权
    轴承结构采用树脂衬套

    公开(公告)号：US08827369B2

    公开(公告)日：2014-09-09

    申请号：US12978835

    申请日：2010-12-27

    申请人： Hiroshi Izawa ,  Makoto Takeuchi ,  Takahiro Kobori

    发明人： Hiroshi Izawa ,  Makoto Takeuchi ,  Takahiro Kobori

    IPC分类号： A47C7/54 ,  B60N2/46 ,  F16C17/00 ,  F16C17/02 ,  F16C33/20

    CPC分类号： A47C7/54 ,  B60N2/753 ,  F16C17/02 ,  F16C33/20 ,  F16C2208/66 ,  F16C2208/76 ,  Y10T403/3981

    摘要： According to a first aspect of the invention, there is provided a bearing structure including: a resin bush having a flange formed to be brought into contact with a plate face around a bearing hole from one side, a locking edge formed to be locked with the plate face around the bearing hole from the other side, and a circular through-hole formed to bear the support shaft inserted therethrough, wherein, upon receiving a load applied to the support shaft, the entire resin bush is flexibly displaced so that an inner circumferential surface of the through-hole is aligned with a hole edge of the bearing hole and the support shaft is born by the hole edge of the bearing hole.

    摘要翻译： 根据本发明的第一方面，提供了一种轴承结构，其包括：树脂衬套，其具有形成为与来自一侧的轴承孔周围的板面接触的凸缘，形成为与所述轴承孔锁定的锁定边缘 板形面从另一侧围绕轴承孔，形成为承载插入其中的支撑轴的圆形通孔，其中，在接收到施加到支撑轴上的负载时，整个树脂衬套被灵活地移位，使得内周 通孔的表面与轴承孔的孔边缘对齐，支撑轴由轴承孔的孔边缘承受。

    Heat engine
    10.
    发明授权
    Heat engine 有权
    热机

    公开(公告)号：US08640453B2

    公开(公告)日：2014-02-04

    申请号：US12821859

    申请日：2010-06-23

    申请人： Makoto Takeuchi

    发明人： Makoto Takeuchi

    IPC分类号： F01B29/08 ,  F01K25/00 ,  F01B29/10 ,  F02G1/04

    CPC分类号： F02G1/044 ,  F02G2243/06

    摘要： A heat engine includes: a high-temperature space portion and a low-temperature space portion, each of which has a working gas with a different temperature range from each other; a regenerator provided between both of the space portions; a first piston configured to cause volumetric changes of the working gases in the space portions and transmit motive energy on receipt of pressure changes of the working gases; and a second piston and a third piston configured to transfer the working gases between both of the space portions and move with a 180° phase difference from each other with respect to the regenerator. The second piston is slidably housed in a cylinder portion included in the first piston. Heat and motive energy are exchanged by using the volumetric changes in both of the space portions, as well as by using the transfer of the working gases.

    摘要翻译： 热机包括：高温空间部分和低温空间部分，每个部分具有彼此具有不同温度范围的工作气体; 设置在两个空间部分之间的再生器; 第一活塞构造成在空间部分中引起工作气体的体积变化，并在接收到工作气体的压力变化时传递动能; 以及第二活塞和第三活塞，其构造成在两个空间部分之间传递工作气体，并相对于再生器以180°的相位差移动。 第二活塞可滑动地容纳在包括在第一活塞中的气缸部分中。 通过使用两个空间部分中的体积变化以及通过使用工作气体的转移来交换热量和动能。