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    ASYMMETRIC CATALYST AND PROCESS FOR PREPARING OPTICALLY ACTIVE ALCOHOLS USING THE SAME
    2.
    发明申请
    ASYMMETRIC CATALYST AND PROCESS FOR PREPARING OPTICALLY ACTIVE ALCOHOLS USING THE SAME 有权
    不对称催化剂及其制备使用其的光学活性醇的方法

    公开(公告)号：US20100261924A1

    公开(公告)日：2010-10-14

    申请号：US12758257

    申请日：2010-04-12

    申请人： Masahito Watanabe ,  Junichi Hori

    发明人： Masahito Watanabe ,  Junichi Hori

    IPC分类号： C07C35/18 ,  C07F15/00 ,  C07C307/02

    CPC分类号： C07B53/00 ,  B01J31/1805 ,  B01J31/2295 ,  B01J2231/643 ,  B01J2531/827 ,  C07F15/0046 ,  C07F17/02

    摘要： The present invention provides an organic metal compound, a ligand, an asymmetric catalyst, and a process for preparing optically-active alcohols using the asymmetric catalyst. The organic metal compound of the present invention is expressed by the following general formula (1): wherein in general formula (1), R1 and R2 are a mutually identical or mutually different, unsubstituted or substituted alkyl group, aryl group, cycloalkyl group, or R1 and R2 are bound to form an alicyclic ring, R3 is a hydrogen atom or an alkyl group, R4 is a branched alkyl group or an alkyl group that does or does not form a ring by itself, or an unsubstituted or substituted aryl group, or an unsubstituted or substituted heterocyclic group, Ar is an unsubstituted or substituted cyclopentadienyl group that is bound to M via a π bond, or an unsubstituted or substituted benzene, X is a hydride group or an anionic group, M is ruthenium, rhodium or iridium, L is a solvent molecule or a water molecule, l is 1 or 2, m is an integer from 0 to 2, n is 0 or 1, and when n is 0, X does not exist, and * represents asymmetric carbon, wherein R4 is not a camphor group, a camphor derivative group, an isopropyl group or a phenyl group whenever R1 and R2 are both a phenyl group.

    摘要翻译： 本发明提供有机金属化合物，配体，不对称催化剂，以及使用不对称催化剂制备光学活性醇的方法。 本发明的有机金属化合物由以下通式（1）表示：其中，通式（1）中，R 1和R 2为相互相同或相互不同的未取代或取代的烷基，芳基，环烷基， 或R 1和R 2结合形成脂环，R 3为氢原子或烷基，R 4为支链烷基或自身不形成环的烷基或未取代或取代的芳基 ，或未取代或取代的杂环基团，Ar是未经取代或取代的环戊二烯基，其经由＆pgr与M结合; 键或未取代或取代的苯，X为氢化物基团或阴离子基团，M为钌，铑或铱，L为溶剂分子或水分子，l为1或2，m为0〜 2，n为0或1，当n为0时，X不存在，*表示不对称碳，其中R 4不是樟脑基，樟脑衍生物基，异丙基或苯基，只要R1和R2为 均为苯基。

    Asymmetric catalyst and process for preparing optically active alcohols using the same
    3.
    发明授权
    Asymmetric catalyst and process for preparing optically active alcohols using the same 有权
    不对称催化剂及使用其制备光学活性醇的方法

    公开(公告)号：US08232420B2

    公开(公告)日：2012-07-31

    申请号：US12758257

    申请日：2010-04-12

    申请人： Masahito Watanabe ,  Junichi Hori

    发明人： Masahito Watanabe ,  Junichi Hori

    IPC分类号： C07F15/00 ,  C07C27/00 ,  C07C303/00

    CPC分类号： C07B53/00 ,  B01J31/1805 ,  B01J31/2295 ,  B01J2231/643 ,  B01J2531/827 ,  C07F15/0046 ,  C07F17/02

    摘要： The present invention provides an organic metal compound, a ligand, an asymmetric catalyst, and a process for preparing optically-active alcohols using the asymmetric catalyst. The organic metal compound of the present invention is expressed by the following general formula (1): wherein in general formula (1), R1 and R2 are a mutually identical or mutually different, unsubstituted or substituted alkyl group, aryl group, cycloalkyl group, or R1 and R2 are bound to form an alicyclic ring, R3 is a hydrogen atom or an alkyl group, R4 is a branched alkyl group or an alkyl group that does or does not form a ring by itself, or an unsubstituted or substituted aryl group, or an unsubstituted or substituted heterocyclic group, Ar is an unsubstituted or substituted cyclopentadienyl group that is bound to M via a π bond, or an unsubstituted or substituted benzene, X is a hydride group or an anionic group, M is ruthenium, rhodium or iridium, L is a solvent molecule or a water molecule, l is 1 or 2, m is an integer from 0 to 2, n is 0 or 1, and when n is 0, X does not exist, and * represents asymmetric carbon, wherein R4 is not a camphor group, a camphor derivative group, an isopropyl group or a phenyl group whenever R1 and R2 are both a phenyl group.

    摘要翻译： 本发明提供有机金属化合物，配体，不对称催化剂，以及使用不对称催化剂制备光学活性醇的方法。 本发明的有机金属化合物由以下通式（1）表示：其中，通式（1）中，R 1和R 2为相互相同或相互不同的未取代或取代的烷基，芳基，环烷基， 或R 1和R 2结合形成脂环，R 3为氢原子或烷基，R 4为支链烷基或自身不形成环的烷基或未取代或取代的芳基 ，或未取代或取代的杂环基团，Ar是未经取代或取代的环戊二烯基，其经由＆pgr与M结合; 键或未取代或取代的苯，X为氢化物基团或阴离子基团，M为钌，铑或铱，L为溶剂分子或水分子，l为1或2，m为0〜 2，n为0或1，当n为0时，X不存在，*表示不对称碳，其中R 4不是樟脑基，樟脑衍生物基，异丙基或苯基，只要R1和R2为 均为苯基。

    NOVEL ORGANIC METAL COMPLEX AND PROCESS FOR PREPARING AMINE COMPOUND
    4.
    发明申请
    NOVEL ORGANIC METAL COMPLEX AND PROCESS FOR PREPARING AMINE COMPOUND 有权
    新的有机金属复合物和制备胺化合物的方法

    公开(公告)号：US20100234596A1

    公开(公告)日：2010-09-16

    申请号：US12722819

    申请日：2010-03-12

    申请人： Masahito Watanabe ,  Junichi Hori ,  Kunihiko Murata

    发明人： Masahito Watanabe ,  Junichi Hori ,  Kunihiko Murata

    IPC分类号： C07C209/28 ,  C07F15/00 ,  C07C253/30 ,  C07C227/18

    CPC分类号： B01J31/2295 ,  C07C209/78 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/008

    摘要： [Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups.[Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.

    摘要翻译： 本发明的目的在于提供一种新的有机金属化合物，其可以用作对官能团具有优异选择性的通用高活性催化剂。 解决问题的手段本发明涉及具有通式（1）的新特异性结构的有机金属化合物：和用于还原胺化反应中的一般用途的高活性催化剂，对包含所述有机金属的官能团具有优异的选择性 化合物，以及通过使用所述催化剂的还原胺化反应制备胺化合物的方法。

    Gene detection method, and intercalator
    7.
    发明授权
    Gene detection method, and intercalator 有权
    基因检测方法和嵌入剂

    公开(公告)号：US07833406B2

    公开(公告)日：2010-11-16

    申请号：US11631609

    申请日：2005-06-30

    申请人： Junichi Hori ,  Ryusuke Murayama ,  Jinpei Tabata ,  Katsuhiko Bando ,  Naoyoshi Egashira

    发明人： Junichi Hori ,  Ryusuke Murayama ,  Jinpei Tabata ,  Katsuhiko Bando ,  Naoyoshi Egashira

    IPC分类号： G01N27/327 ,  G01N21/76 ,  C09K3/00

    CPC分类号： G01N21/66 ,  C12Q1/6825 ,  C12Q2563/173 ,  C12Q2563/113 ,  C12Q2523/313

    摘要： A gene detection method for detecting a gene having a specific sequence with high sensitivity is provided. The gene detection method comprises a double-stranded nucleic acid formation step of forming double-stranded nucleic acid by hybridizing a nucleic acid probe immobilized on an electrode and a gene sample; a step of adding an intercalator which comprises a compound having a double-stranded nucleic acid binding site Ia that is specifically intercalated into the double-stranded nucleic acid and is covalently bonded to the double-stranded nucleic acid by light irradiation, an electrochemical active site Fa having electrochemical activity, and a connecting site La for connecting the double-stranded nucleic acid binding site Ia and the electrochemical active site Fa, and has an substitution group comprising one of compounds represented by -Lb-Ib and -Lc-Fb or a combination of the both compounds, at each of the respective sites; a light irradiation step of covalently bonding the double-stranded nucleic acid and the intercalator; and a detection step of detecting the intercalator covalently bonded to the double-stranded nucleic acid by electrochemical measurement.

    摘要翻译： 提供了用于检测具有高灵敏度的特定序列的基因的基因检测方法。 基因检测方法包括通过杂交固定在电极上的核酸探针和基因样品来形成双链核酸的双链核酸形成步骤; 添加嵌段剂的步骤，其包含具有特异插入到双链核酸中并通过光照射共价结合到双链核酸的双链核酸结合位点Ia的化合物，电化学活性位点 具有电化学活性的Fa，以及用于连接双链核酸结合位点Ia和电化学活性位点Fa的连接位点La，并且具有包含由-Lb-Ib和-Lc-Fb表示的化合物之一的取代基或 两个化合物的组合，在各个位置的每一个; 共价键合双链核酸和嵌入剂的光照射步骤; 以及通过电化学测定来检测共价键合到双链核酸的嵌入剂的检测步骤。

    Gene Detection Method, and Intercalator
    8.
    发明申请
    Gene Detection Method, and Intercalator 有权
    基因检测方法和嵌入剂

    公开(公告)号：US20090000962A1

    公开(公告)日：2009-01-01

    申请号：US11631609

    申请日：2005-06-30

    申请人： Junichi Hori ,  Ryusuke Murayama ,  Jinpei Tabata ,  Katsuhiko Bando ,  Naoyoshi Egashira

    发明人： Junichi Hori ,  Ryusuke Murayama ,  Jinpei Tabata ,  Katsuhiko Bando ,  Naoyoshi Egashira

    IPC分类号： G01N27/26 ,  C07H21/00

    CPC分类号： G01N21/66 ,  C12Q1/6825 ,  C12Q2563/173 ,  C12Q2563/113 ,  C12Q2523/313

    摘要： A gene detection method for detecting a gene having a specific sequence with high sensitivity is provided. The gene detection method comprises a double-stranded nucleic acid formation step of forming double-stranded nucleic acid by hybridizing a nucleic acid probe immobilized on an electrode and a gene sample; a step of adding an intercalator which comprises a compound having a double-stranded nucleic acid binding site Ia that is specifically intercalated into the double-stranded nucleic acid and is covalently bonded to the double-stranded nucleic acid by light irradiation, an electrochemical active site Fa having electrochemical activity, and a connecting site La for connecting the double-stranded nucleic acid binding site Ia and the electrochemical active site Fa, and has an substitution group comprising one of compounds represented by -Lb-Ib and -Lc-Fb or a combination of the both compounds, at each of the respective sites; a light irradiation step of covalently bonding the double-stranded nucleic acid and the intercalator; and a detection step of detecting the intercalator covalently bonded to the double-stranded nucleic acid by electrochemical measurement.

    摘要翻译： 提供了用于检测具有高灵敏度的特定序列的基因的基因检测方法。 基因检测方法包括通过杂交固定在电极上的核酸探针和基因样品来形成双链核酸的双链核酸形成步骤; 添加嵌段剂的步骤，其包含具有特异插入到双链核酸中并通过光照射共价结合到双链核酸的双链核酸结合位点Ia的化合物，电化学活性位点 具有电化学活性的Fa，以及用于连接双链核酸结合位点Ia和电化学活性位点Fa的连接位点La，并且具有包含由-Lb-Ib和-Lc-Fb表示的化合物之一的取代基或 两个化合物的组合，在各个位置的每一个; 共价键合双链核酸和嵌入剂的光照射步骤; 以及通过电化学测定来检测共价键合到双链核酸的嵌入剂的检测步骤。

    Inflating type occupant restraint device
    9.
    发明授权
    Inflating type occupant restraint device 失效
    充气式乘员约束装置

    公开(公告)号：US4148503A

    公开(公告)日：1979-04-10

    申请号：US729848

    申请日：1976-10-05

    申请人： Harunori Shiratori ,  Yoshio Yamazaki ,  Takaharu Yoshimi ,  Junichi Hori

    发明人： Harunori Shiratori ,  Yoshio Yamazaki ,  Takaharu Yoshimi ,  Junichi Hori

    IPC分类号： B60R21/20 ,  B60R21/203 ,  B60R21/215 ,  B60R21/2165 ,  B60R21/08

    CPC分类号： B60R21/21656 ,  B60R21/2035

    摘要： A receiving case for receiving a gas bag is formed of a side wall portion secured to a fixed member and a lid surface portion thinner than the side wall portion by the use of a material having a comparatively high hardness and a ductility. Further, the lid surface portion is formed with fragile portions contiguous to one another. At the inflation of the gas bag, the receiving case for the gas bag is prevented from scattering in the form of broken pieces, and the gas bag is prevented from being damaged by a sharp edge otherwise arising at the fracture surface of the receiving case.

    摘要翻译： 用于接收气囊的接收盒由通过使用具有较高硬度和延展性的材料固定到固定部件的侧壁部分和比侧壁部分更薄的盖表面部分形成。 此外，盖表面部分形成有彼此相邻的易碎部分。 在气囊膨胀的情况下，防止气囊的接收壳体以碎片的形式散射，并且防止气囊被接收壳体的断裂面处的尖锐边缘损坏。