公开(公告)号：US5434298A

公开(公告)日：1995-07-18

申请号：US30063

申请日：1993-03-12

申请人： Masakazu Negawa ,  Fumihiko Shoji

发明人： Masakazu Negawa ,  Fumihiko Shoji

IPC分类号： B01D15/00 ,  B01D15/18 ,  B01D15/38 ,  C07B57/00 ,  C07C29/76 ,  C07C33/22 ,  C07C67/48 ,  C07C69/16 ,  B01D15/08

CPC分类号： B01D15/185 ,  B01D15/3833 ,  C07B57/00

摘要： A process for recovering and reusing a solvent and optical isomers, characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed column containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

摘要翻译： PCT No.PCT / JP92 / 01024 Sec。 371日期1993年3月12日 102（e）日期1993年3月12日PCT提交1992年8月10日PCT公布。 第WO93 / 04022号公报 日本1993年3月4日。一种用于回收和再利用溶剂和光学异构体的方法，其特征在于使用模拟移动填充床，其包括用于洗脱液的入口，用于含有强烈吸附在包装上的光学异构体的提取物的出口， 含有光学异构体混合物的液体的入口和含有在包装上弱吸附的光学异构体的提余液的出口，该填充床中含有用于光学拆分并排列在溶剂循环通道中的填料床，并且其中 入口和出口间歇地连续地沿填充床中的液体流动方向移动; 从所得萃取物和/或萃余液中回收溶剂和旋光异构体; 将回收的溶剂返回到溶剂循环通道中; 或者当溶剂未回收时，加热提取物或提余液以使不期望的旋光异构体外消旋化并重复使用含有外消旋变体的所得溶液以用模拟移动床系统分离光学异构体。

公开(公告)号：US5434299A

公开(公告)日：1995-07-18

申请号：US156264

申请日：1993-11-22

申请人： Masakazu Negawa ,  Fumihiko Shoji

发明人： Masakazu Negawa ,  Fumihiko Shoji

IPC分类号： B01D15/00 ,  B01D15/18 ,  B01D15/38 ,  C07B57/00 ,  C07C29/76 ,  C07C33/22 ,  C07C67/48 ,  C07C69/16 ,  B01D15/08

CPC分类号： B01D15/185 ,  B01D15/3833 ,  C07B57/00

摘要： A process for recovering and reusing a solvent and optical isomers characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed column containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

摘要翻译： 一种用于回收和再利用溶剂和旋光异构体的方法，其特征在于使用模拟移动填充床，其包括用于洗脱液的入口，用于含有强吸附在包装上的光学异构体的提取物的出口，用于含有光学 异构体混合物和含有在包装上弱吸附的光学异构体的提余液的出口，在包含用于光学拆分的填料的填充床柱中，并且排列在溶剂循环通道中，并且其中入口和出口间歇地和连续地 沿填充床内的液体流动方向移动; 从所得萃取物和/或萃余液中回收溶剂和旋光异构体; 将回收的溶剂返回到溶剂循环通道中; 或者当溶剂未回收时，加热提取物或提余液以使不期望的旋光异构体外消旋化并重复使用含有外消旋变体的所得溶液以用模拟移动床系统分离光学异构体。

公开(公告)号：US5498752A

公开(公告)日：1996-03-12

申请号：US202970

申请日：1994-02-28

申请人： Masakazu Negawa ,  Fumihiko Shoji

发明人： Masakazu Negawa ,  Fumihiko Shoji

IPC分类号： B01D15/18 ,  B01D15/38 ,  C07B57/00 ,  B01D15/08

CPC分类号： B01D15/185 ,  B01D15/3833 ,  C07B57/00

摘要： A process for recovering and reusing a solvent and optical isomers, characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed: recovering the solvent and the optical isomer(s) from The resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

摘要翻译： 一种用于回收和再利用溶剂和光学异构体的方法，其特征在于使用模拟移动填充床，其包括用于洗脱液的入口，用于含有强吸附在所述填料上的光学异构体的提取物的出口， 光学异构体混合物和含有在包装上弱吸附的光学异构体的提余液的出口，在包含用于光学拆分的填料的填充床中，并排列在溶剂循环通道中，并且其中入口和出口间歇地和连续地 在填充床中的液体流动方向上移动：从所得到的提取物和/或残液中回收溶剂和旋光异构体; 将回收的溶剂返回到溶剂循环通道中; 或者当溶剂未回收时，加热提取物或提余液以使不期望的旋光异构体外消旋化并重复使用含有外消旋变体的所得溶液以用模拟移动床系统分离光学异构体。

公开(公告)号：US5456825A

公开(公告)日：1995-10-10

申请号：US85444

申请日：1993-06-30

申请人： Masakazu Negawa ,  Fumihiko Shoji

发明人： Masakazu Negawa ,  Fumihiko Shoji

IPC分类号： B01D53/00 ,  B01D15/18 ,  B01J8/04 ,  C07B57/00 ,  B01D24/10 ,  C07C7/12

CPC分类号： B01D15/1842 ,  B01J8/04 ,  B01J8/0457 ,  C07B57/00 ,  B01D2215/023 ,  B01D2215/024 ,  B01D2215/027

摘要： An improved simulated moving bed separation system is disclosed. The improved novel system is characterized by being provided with rotary valves or check valves or both. The rotary valves are provided at the position where desorbing liquid is introduced, the position where the extract is taken out, the position where the feedstock is introduced and the position where the raffinate is taken out and the rotary valves are intermittently switched on and off, whereby the liquid take out of the unit packed bed preceding the position where the desorbing liquid is introduced is supplied to the circulation pump. The check valves are provided in the fluid flow passage between a unit packed bed and an extract draw-out port positioned in the next unit packed bed in the direction in the next unit packed bed in the direction of fluid flow. Thus liquid flow is smoothly controlled and the more effective separation is realized.

摘要翻译： 公开了一种改进的模拟移动床分离系统。 改进的新型系统的特征在于设置有旋转阀或止回阀或两者。 旋转阀设置在引入解吸液体的位置，取出提取物的位置，引入原料的位置和取出残液的位置以及旋转阀间断地打开和关闭， 从而在引入解吸液体的位置之前将液体从单元填充床中取出供给循环泵。 止回阀设置在位于下一个单元填充床中的单元填充床和抽出物抽出口之间的流体流动通道中，沿着流体流动方向在下一个单元填充床中的方向。 因此，液体流动被平稳地控制并且实现更有效的分离。

公开(公告)号：US5770088A

公开(公告)日：1998-06-23

申请号：US771430

申请日：1996-12-20

申请人： Hirokazu Ikeda ,  Masakazu Negawa ,  Fumihiko Shoji

发明人： Hirokazu Ikeda ,  Masakazu Negawa ,  Fumihiko Shoji

IPC分类号： B01D15/18 ,  B01J8/04 ,  B01D15/08

CPC分类号： B01D15/1828 ,  B01J8/0457 ,  B01D2215/027

摘要： In the simulated moving bed chromatographic separation process, preferably using a simulated moving bed chromatographic separation apparatus with rotary valves and/or check valves, a supercritical fluid is used as an eluent and thereby efficiency in separation and operation is remarkably improved and the concentration step after the chromatographic separation is not required.

摘要翻译： 在模拟移动床层析分离方法中，优选使用具有旋转阀和/或止回阀的模拟移动床色谱分离装置，使用超临界流体作为洗脱剂，从而显着提高分离和操作的效率，并且浓缩步骤 不需要色谱分离。

公开(公告)号：US5763645A

公开(公告)日：1998-06-09

申请号：US556568

申请日：1995-11-13

申请人： Masakazu Negawa ,  Fumihiko Shoji

发明人： Masakazu Negawa ,  Fumihiko Shoji

IPC分类号： B01D15/18 ,  B01D15/38 ,  C07B57/00 ,  C07C67/48

CPC分类号： B01D15/185 ,  B01D15/3833 ,  C07B57/00

摘要： A process for recovering and reusing a solvent and optical isomers, characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

摘要翻译： 一种用于回收和再利用溶剂和光学异构体的方法，其特征在于使用模拟移动填充床，其包括用于洗脱液的入口，用于含有强吸附在所述填料上的光学异构体的提取物的出口， 光学异构体混合物和含有在包装上弱吸附的光学异构体的提余液的出口，在包含用于光学拆分的填料的填充床中，并排列在溶剂循环通道中，并且其中入口和出口间歇地和连续地 沿填充床内的液体流动方向移动; 从所得萃取物和/或萃余液中回收溶剂和旋光异构体; 将回收的溶剂返回到溶剂循环通道中; 或者当溶剂未回收时，加热提取物或提余液以使不期望的旋光异构体外消旋化并重复使用含有外消旋变体的所得溶液以用模拟移动床系统分离光学异构体。

公开(公告)号：USRE35919E

公开(公告)日：1998-10-13

申请号：US911680

申请日：1997-08-15

申请人： Akira Yamashita ,  Fumihiko Shoji

发明人： Akira Yamashita ,  Fumihiko Shoji

IPC分类号： B01D15/00 ,  C07B57/00 ,  C07C29/76 ,  C07C33/22 ,  C07C67/56 ,  C07C69/16 ,  B01D15/08

CPC分类号： C07B57/00 ,  B01D15/1821 ,  B01D15/3833

摘要： A process for separating optical isomers in a simulated moving bed system, which comprises introducing a solution containing an optical isomer mixture and a desorbing liquid into a packed bed containing an optical resolution packing therein and having front and rear ends thereof connected to each other endlessly via a fluid passage to circulate a fluid unidirectionally and at the same time drawing out a solution containing one of the separated isomers and another solution containing the other isomer from the packed bed, wherein a port 13 for introducing a desorbing liquid, a port 14 for drawing out a solution containing a strongly adsorbable optical isomer, i.e. an extract, a port 15 for introducing a solution containing a mixture of optical isomers, and a port 16 for drawing out a solution containing a weakly adsorbable optical isomer, i.e. a raffinate, are arranged in the packed bed in this order along the direction of fluid flow and the positions of these ports are successively moved in the direction of fluid flow in the packed bed intermittently.

摘要翻译： PCT No.PCT / JP91 / 00213 Sec。 371日期1991年8月21日 102（e）日期1991年8月21日PCT 1991年2月20日PCT PCT。 公开号WO91 / 13046 日本1991年9月5日在模拟移动床系统中分离光学异构体的方法，其包括将含有光学异构体混合物和解吸液体的溶液引入到其中包含光学分辨率包装的填充床中，并且其前端和后端连接 通过流体通道彼此不间断地循环流体，同时从填充床中抽出含有一种分离异构体的溶液和另一种含有其它异构体的溶液，其中用于引入解吸液体的端口13， 用于抽出含有强吸附光学异构体的溶液的端口14，即提取物，用于引入含有光学异构体混合物的溶液的端口15和用于抽出含有弱吸附光学异构体的溶液的端口16，即， 一个提余液沿着流体流动的方向排列在填充床中，并且这些端口的位置 连续地在填充床中的流体流动方向间歇地移动。

公开(公告)号：US5126055A

公开(公告)日：1992-06-30

申请号：US752663

申请日：1991-08-21

申请人： Akira Yamashita ,  Fumihiko Shoji

发明人： Akira Yamashita ,  Fumihiko Shoji

IPC分类号： B01D15/00 ,  C07B57/00 ,  C07C29/76 ,  C07C33/22 ,  C07C67/56 ,  C07C69/16

CPC分类号： C07B57/00 ,  B01D15/1821 ,  B01D15/3833

摘要： A process for separating optical isomers in a simulated moving bed system, which comprises introducing a solution containing an optical isomer mixture and a desorbing liquid into a packed bed containing an optical resolution packing therein and having front and rear ends thereof connected to each other endlessly via a fluid passage to circulate a fluid unidirectionally and at the same time drawing out a solution containing one of the separated isomers and another solution containing the other isomer from the packed bed, wherein a port 13 for introducing a desorbing liquid, a port 14 for drawing out a solution containing a strongly adsorbable optical isomer, i.e. an extract, a port 15 for introducing a solution containing a mixture of optical isomers, and a port 16 for drawing out a solution containing a weakly adsorbable optical isomer, i.e. a raffinate, are arranged in the packed bed in this order along the direction of fluid flow and the positions of these ports are successively moved in the direction of fluid flow in the packed bed intermittently.