公开(公告)号：US07399898B2

公开(公告)日：2008-07-15

申请号：US11100041

申请日：2005-04-06

申请人： Jin Suk Lee ,  Nam Cheol Shin

发明人： Jin Suk Lee ,  Nam Cheol Shin

IPC分类号： C07C7/12 ,  B01J8/18 ,  B01D15/08

CPC分类号： C07C7/12 ,  B01D15/1842 ,  B01D2215/024

摘要： Disclosed is a simulated moving bed (SMB) adsorptive separation system in which at least one component of a fluid mixture is brought into contact with a solid adsorbent and the adsorbed component is desorbed with a desorbent, wherein the improvement comprises an inert ball layer is formed on the upper part of the solid absorbent filled in the simulated moving bed.

摘要翻译： 公开了一种模拟移动床（SMB）吸附分离系统，其中流体混合物的至少一种组分与固体吸附剂接触并且吸附的组分用解吸剂解吸，其中改进包括形成惰性球层 在填充在模拟移动床中的固体吸收剂的上部。

公开(公告)号：US07390412B2

公开(公告)日：2008-06-24

申请号：US10867790

申请日：2004-06-16

申请人： Didier Pavone

发明人： Didier Pavone

IPC分类号： B01D15/08

CPC分类号： B01D15/1828 ,  B01D2215/024 ,  Y10T137/0357

摘要： A method of managing the valves of a simulated moving bed separation system comprising at least one column of adsorbent beds split into several zones delimited by injection and draw-off points, allowing finer monitoring of a determined concentration profile. The method comprises, during each period between the shift times of the injection and draw-off points, in opening and closing a first valve located at one end of a zone according to a determined law, while opening and closing the valve downstream from the first valve in relation to the direction of flow of the recirculation flow, according to the same law with a lag, referred to as overlap time, in relation to the first valve, which is less than or equal to the period, the law imposing a constant total flow rate for the flow passing through the two consecutive valves throughout the overlap time. Applications are any simulated moving bed separation system, preferably those used for relatively small-tonnage production such as fine petrochemistry, pharmaceutical industry, certain food processing industries, etc.

摘要翻译： 一种管理模拟移动床分离系统的阀的方法，该系统包括至少一列吸附床，该吸附床被分成由注射和抽出点限定的若干区域，从而允许更精细地监测确定的浓度分布。 该方法包括在喷射和排出点的换档时间之间的每个周期期间，根据确定的定律打开和关闭位于区域的一端的第一阀，同时在第一阀的下游打开和关闭阀 阀门相对于再循环流动的流动方向，根据相对于第一阀门（称为重叠时间）的延迟相同的规则，该滞后时间小于或等于施加常数的法律的第一阀门 在整个重叠时间内通过两个连续阀的流量的总流量。 应用是任何模拟移动床分离系统，优选用于相对较小吨位生产的移动床分离系统，如精细石油化学，制药工业，某些食品加工业等。

公开(公告)号：US6063285A

公开(公告)日：2000-05-16

申请号：US318574

申请日：1999-05-27

申请人： Gerard Hotier ,  Albert Le Corre ,  Dominique Humeau ,  Pierre Renard

发明人： Gerard Hotier ,  Albert Le Corre ,  Dominique Humeau ,  Pierre Renard

IPC分类号： B01D15/00 ,  B01D15/18 ,  C07C7/12 ,  B01D15/08

CPC分类号： B01D15/1842 ,  C07C7/12 ,  B01D2215/024

摘要： An apparatus and process for regulating the flow rate of at least one fluid or effluent circulating in a simulated moving bed comprises a plurality of beds disposed in a closed loop in at least one chromatographic column (1) and comprising at least one means for recirculating fluid and comprising at least two lines for injecting fluid at a controlled flow rate and at least two lines for withdrawing fluid, one of said withdrawal (extract or raffinate) lines being under flow rate control, the other (60) being under pressure control via at least one control valve (6), and is characterized in that said pressure controlled withdrawal line (60) comprises, in addition to the control valve, comprises at least one restriction means (201) enabling the pressure downstream of at least one of the beds to be reduced. One embodiment of the use of the invention is for separating a xylene isomer.

摘要翻译： 用于调节在模拟移动床中循环的至少一种流体或流出物的流速的装置和方法包括在至少一个色谱柱（1）中设置在闭环中的多个床，并且包括至少一个用于再循环流体的装置 并且包括用于以受控流速喷射流体的至少两条线和用于抽出流体的至少两条线，所述抽出（提取物或提余液）管线之一处于流量控制之下，另一条管线（60）在压力控制下通过 至少一个控制阀（6），其特征在于，所述压力控制抽出管线（60）除了所述控制阀之外还包括至少一个限制装置（201），所述至少一个限制装置能使所述床中的至少一个床 要减少 本发明使用的一个实施方案是分离二甲苯异构体。

公开(公告)号：US5972224A

公开(公告)日：1999-10-26

申请号：US42572

申请日：1998-03-17

申请人： Gerard Hotier ,  Pierre Renard ,  Annick Pucci ,  Didier Pavone

发明人： Gerard Hotier ,  Pierre Renard ,  Annick Pucci ,  Didier Pavone

IPC分类号： B01D15/18 ,  B01D15/08

CPC分类号： B01D15/1842 ,  B01D15/1828 ,  B01D2215/023 ,  B01D2215/024

摘要： The device comprises at least one column 1 that is filled with a number of beds A.sub.n having an adsorbent that are separated by a fluid distributor plate P.sub.i. Each plate is divided into a number of sectors P.sub.10 and P.sub.11, and each sector comprises at least one fluid distribution chamber 13 that is pierced with openings and a circulation space 8 in the vicinity of the openings. The chambers of the plate are connected to a line 10 for transfer to the outside. With respect to the chambers on a plate, transfer line 10 P.sub.i is connected to another transfer line 20 relative to chambers 23 on another plate (P.sub.i+1 or P.sub.i+2) that is arranged downstream by a bypass line L.sub.1,2. The latter comprises means 14, 15, 16 for monitoring and adjustment of the flow of fluid that circulates there, such that the distribution chambers are flushed by a fluid which has approximately the same composition as that of the fluid that circulates through circulation space 8 at each of the chambers.

摘要翻译： 该装置包括至少一个填充有多个床的柱1，其具有由流体分配器板Pi分离的吸附剂。 每个板被分成多个扇区P10和P11，并且每个扇区包括至少一个在开口附近被开口的流体分配室13和循环空间8。 板的腔室连接到管线10以转移到外部。 相对于板上的室，传输线10 Pi相对于另一个板（Pi + 1或Pi + 2）上的腔室23连接到另一个传输线20，该另一个板（Pi + 1或Pi + 2）被布置在旁路线L1,2的下游。 后者包括用于监测和调节在那里循环的流体流动的装置14,15,16，使得分配室被流体冲洗，流体具有与通过循环空间8循环的流体大致相同的组成 每个房间。

公开(公告)号：US12097448B2

公开(公告)日：2024-09-24

申请号：US17330652

申请日：2021-05-26

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： Jyrki Airaksinen ,  Kari Laiho

IPC分类号： B01D15/18 ,  B01D15/36 ,  C13B20/14 ,  C13B35/06 ,  C13K13/00

CPC分类号： B01D15/1828 ,  B01D15/185 ,  B01D15/362 ,  C13B20/148 ,  C13B35/06 ,  C13K13/007 ,  B01D2215/024

摘要： The present invention relates to a method for fractionating a feedstock into two or more fractions enriched with different components, and more particularly to a method for fractionating a feedstock into two or more fractions by a chromatographic sequential simulated moving bed (SMB) system, wherein the SMB system comprises a separation loop comprising at least 2 compartments; and wherein the method comprises a separation cycle comprising at least one feeding step, at least one circulating step and at least one eluting step; wherein the dissolved substances in the feedstock form a separation profile as they progress through the separation loop; and the separation profile is progressed more than once or less than once through the separation loop in each separation cycle; and wherein at least two flow paths are present in the separation loop during each feeding step of the separation cycle; and at least one of said flow paths is an active flow path and at least one of said flow paths is an inactive flow path.

公开(公告)号：US20240082752A1

公开(公告)日：2024-03-14

申请号：US18509100

申请日：2023-11-14

申请人： Novasep Process Solutions

发明人： Cédric Prieur ,  Eric Valéry

IPC分类号： B01D15/18 ,  C13K1/04 ,  C13K11/00

CPC分类号： B01D15/1828 ,  B01D15/185 ,  C13K1/04 ,  C13K11/00 ,  B01D2215/024

摘要： The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.

公开(公告)号：US06896812B1

公开(公告)日：2005-05-24

申请号：US10621622

申请日：2003-07-17

申请人： Stanley J. Frey

发明人： Stanley J. Frey

IPC分类号： B01D15/08 ,  B01D15/18

CPC分类号： B01D15/1828 ,  B01D2215/024

摘要： Fluctuations, such as perturbations in the quality of the extract and/or raffinate streams removed from the circuit in a simulated moving bed (SMB) adsorptive process having at least one discrete non-separating section are eliminated or significantly reduced. This is accomplished by increasing the fluid flow rate in a portion of the circuit in response to the location of a discrete non-separating section and changing the flow rate of at least one stream that is in fluid communication with the circuit consistent with the increased flow rate in the portion of the circuit. Multiple adjustments to the flow rates of the input and/or output streams and multiple increases in the fluid flow rates in portions of the circuit may be used simultaneously when for example there is more than one discrete non-separating section.

摘要翻译： 在具有至少一个离散非分离部分的模拟移动床（SMB）吸附方法中，从电路中除去的提取物和/或提余液流的质量的波动被消除或显着减少。 这是通过响应于离散的非分离部分的位置增加电路的一部分中的流体流速来实现的，并且改变与电路流体连通的至少一个流的流速，与流动的流量一致 率在电路部分。 当例如存在多于一个离散的非分离部分时，可以同时使用输入和/或输出流的流量的多个调整以及电路部分中的流体流速的多次增加。

公开(公告)号：US06332982B1

公开(公告)日：2001-12-25

申请号：US09525454

申请日：2000-03-15

申请人： Gérard Hotier ,  Albert Le Corre ,  Dominique Humeau ,  Pierre Renard

发明人： Gérard Hotier ,  Albert Le Corre ,  Dominique Humeau ,  Pierre Renard

IPC分类号： B01D1508

CPC分类号： B01D15/1842 ,  B01D2215/024 ,  C07C7/12 ,  C07C15/08

摘要： An apparatus and process for regulating the flow rate of at least one fluid or effluent circulating in a simulated moving bed comprises a plurality of beds disposed in a closed loop in at least one chromatographic column (1) and comprising at least one means for recirculating fluid and comprising at least two lines for injecting fluid at a controlled flow rate and at least two lines for withdrawing fluid, one of said withdrawal (extract or raffinate) lines being under flow rate control, the other (60) being under pressure control via at least one control valve (6), and is characterized in that said pressure controlled withdrawal line (60) comprises, in addition to the control valve, comprises at least one restriction means (201) enabling the pressure downstream of at least one of the beds to be reduced. One embodiment of the use of the invention is for separating a xylene isomer.

摘要翻译： 用于调节在模拟移动床中循环的至少一种流体或流出物的流速的装置和方法包括在至少一个色谱柱（1）中设置在闭环中的多个床，并且包括至少一个用于再循环流体的装置 并且包括用于以受控流速喷射流体的至少两条线和用于抽出流体的至少两条线，所述抽出（提取物或提余液）管线之一处于流量控制之下，另一条管线（60）在压力控制下通过 至少一个控制阀（6），其特征在于，所述压力控制抽出管线（60）除了所述控制阀之外还包括至少一个限制装置（201），所述至少一个限制装置能使所述床中的至少一个床 要减少 本发明使用的一个实施方案是分离二甲苯异构体。

公开(公告)号：US5422007A

公开(公告)日：1995-06-06

申请号：US170248

申请日：1993-12-27

申请人： Roger Nicoud ,  Michel Perrut ,  Gerard Hotier

发明人： Roger Nicoud ,  Michel Perrut ,  Gerard Hotier

IPC分类号： B01D20060101 ,  B01D15/02 ,  B01D15/08 ,  B01D15/18 ,  G01N30/00 ,  G01N30/02 ,  G01N30/44 ,  G01N30/46

CPC分类号： B01D15/1842 ,  B01D2215/023 ,  B01D2215/024 ,  B01D2215/025 ,  B01D2215/027

摘要： An apparatus and process for fractionation of component mixtures by chromatography or adsorption on a simulated mobile bed comprising three, four or five zones is described. A compressed gas is injected as eluent (IE, IR) using a compressor or pump, the pressure being lower than the critical pressure of the gas. At any point in at least one zone and preferably at any point in at least two zones from the eluent injection point (IR), the gas has a compressibility coefficient substantially different to 1. A supercritical fluid or a subcritical liquid may equally be injected as the eluent. The pressure between each zone may be altered.

摘要翻译： PCT No.PCT / FR93 / 00419 Sec。 371日期1993年12月27日第 102（e）日期1993年12月27日PCT提交1993年4月28日PCT公布。 出版物WO93 / 22022 日期11月11日，1993年。描述了通过色谱法或吸附在包含三个，四个或五个区域的模拟移动床上分馏组分混合物的装置和方法。 使用压缩机或泵将压缩气体作为洗脱液（IE，IR）注入，压力低于气体的临界压力。 在至少一个区域中的任何点，优选地在至少两个洗脱液注入点（IR）的区域中的任何点处，该气体具有与1大致不同的压缩系数。超临界流体或亚临界液体可同样注入 洗脱液。 每个区域之间的压力可能会改变。

公开(公告)号：US5156736A

公开(公告)日：1992-10-20

申请号：US696515

申请日：1991-05-07

申请人： Karlheinz W. R. Schoenrock

发明人： Karlheinz W. R. Schoenrock

IPC分类号： B01D15/18

CPC分类号： B01D15/1842 ,  B01D2215/023 ,  B01D2215/024

摘要： An apparatus and process for concentrating a selected component from a multi-component liquid using a sorbent bed having a preferential sorption rate for the selected component. The sorbent bed is enclosed in a single vessel and is operated in a simulated moving bed technique whereby the flow profile of the liquid is continually moved downwardly through the sorbent bed. Recirculation is continuous but variable and is accompanied by the injection of eluent and feedstock and the removal of extract and raffinate at preselected times, locations, and amounts as a function of the kinetics and voidage of the sorbent bed. Extract purity and operational efficiency of the sorbent bed are the result of this novel apparatus and process.

摘要翻译： 一种用于使用对所选择的组分具有优选吸附速率的吸附剂床从多组分液体中浓缩选定组分的装置和方法。 吸附剂床封闭在单个容器中并且以模拟移动床技术操作，由此液体的流动分布不断地向下移动通过吸附剂床。 再循环是连续的但可变的，伴随着洗脱剂和原料的注入以及在预选时间，位置和量下除去萃取物和萃余液作为吸附剂床的动力学和空隙度的函数。 提取吸附剂床的纯度和操作效率是这种新型设备和工艺的结果。