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    OF4949
    6.
    发明授权
    OF4949 失效

    公开(公告)号：US4554289A

    公开(公告)日：1985-11-19

    申请号：US564923

    申请日：1983-12-23

    申请人： Susumu Sano ,  Katsushige Ikai ,  Hiroyuki Kuroda ,  Teruya Nakamura ,  Hiroshi Enomoto ,  Yoji Ezure

    发明人： Susumu Sano ,  Katsushige Ikai ,  Hiroyuki Kuroda ,  Teruya Nakamura ,  Hiroshi Enomoto ,  Yoji Ezure

    IPC分类号： C07K5/087 ,  A61K31/395 ,  C07D273/08 ,  C12P17/14

    CPC分类号： C12R1/80 ,  C07K5/0812

    摘要： Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen, alkyl of 1 to 10 carbon atoms or acyl of 1 to 6 carbon atoms; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms or acyl of 1 to 6 carbon atoms; R.sup.4 is hydrogen or alkyl of 1 to 6 carbon atoms; R.sup.5 is hydrogen or acyl of 1 to 6 carbon atoms; X is CONH.sub.2, hydroxyalkyl of 1 to 4 carbon atoms or COOR.sup.6 wherein R.sup.6 is hydrogen or alkyl of 1 to 4 carbon atoms; and Y is CONH.sub.2, hydroxyalkyl of 1 to 4 carbon atoms or COOR.sup.7 wherein R.sup.7 is hydrogen, alkyl of 1 to 10 carbon atoms or benzyl are useful for inhibiting the activity of amino-peptidase B, exhibit immunomodulating action against living organisms and exhibit anti-inflammatory activity.

    摘要翻译： 式（I）化合物：其中R 1为氢，1至10个碳原子的烷基或1至6个碳原子的酰基的药学上可接受的盐; R2是氢或卤素; R3是氢，1至6个碳原子的烷基或1至6个碳原子的酰基; R4是氢或1至6个碳原子的烷基; R5是氢或1至6个碳原子的酰基; X是CONH 2，1至4个碳原子的羟烷基或COOR 6，其中R 6是氢或1至4个碳原子的烷基; Y为CONH 2，1〜4个碳原子的羟基烷基或COOR 7，其中R 7为氢，1〜10个碳原子的烷基或苄基可用于抑制氨基肽酶B的活性，表现出对活生物体的免疫调节作用， 炎症活动。

    Glucosylmoranoline derivatives
    9.
    发明授权
    Glucosylmoranoline derivatives 失效
    葡糖基吗啉衍生物

    公开(公告)号：US4855415A

    公开(公告)日：1989-08-08

    申请号：US91822

    申请日：1987-09-01

    申请人： Makoto Sugiyama ,  Yoji Ezure ,  Yoshiaki Yoshikuni ,  Yukio Fujita

    发明人： Makoto Sugiyama ,  Yoji Ezure ,  Yoshiaki Yoshikuni ,  Yukio Fujita

    IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P3/08 ,  C07H17/02

    CPC分类号： C07H17/02 ,  Y10S514/866

    摘要： A compound of formula (I) ##STR1## wherein: B is a divalent substituted or unsubstituted, cyclic or acyclic, saturated or unsaturated hydrocarbon group;A is a linking group selected from the group consisting of --O--, --S--, --N(H)--, --N(R)--, --C(O)-- and combinations of two or more thereof or A is a direct bond; andR is a monovalent substituted or unsubstituted, cyclic or acyclic, saturated or unsaturated hydrocarbon group, a monovalent substituted or unsubstituted aromatic hydrocarbon group, or a monovalent substituted or unsubstituted heterocyclyl provided that B--A--R may not represent hydrogen, lower alkyl, or a monovalent cyclic or acyclic hydrocarbon group having one or more hydroxyl groups, which is useful for inhibiting an increase in blood glucose in humans and for the treatment of diabetes mellitus.