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    Communication device, power supplying method therefor, and power supply system
    1.
    发明授权
    Communication device, power supplying method therefor, and power supply system 有权
    通信设备，供电方式和电源系统

    公开(公告)号：US08724277B2

    公开(公告)日：2014-05-13

    申请号：US13161363

    申请日：2011-06-15

    申请人： Masanori Baba ,  Tsuyoshi Yamaguchi ,  Yoshimi Tokunaga ,  Mutsuhiko Ooishi

    发明人： Masanori Baba ,  Tsuyoshi Yamaguchi ,  Yoshimi Tokunaga ,  Mutsuhiko Ooishi

    IPC分类号： G06F1/32

    CPC分类号： H04L12/10 ,  H02J1/06 ,  H04N5/63 ,  Y10T307/766 ,  Y10T307/832

    摘要： A communication device that establishes a communication with another communication device and supplies electric power to the other communication device by way of a transmission channel, the device comprises a supply voltage generation section that generates a supply voltage, a first detection section that detects a connection of an electric device other than the other communication device to the transmission channel, and an output control section that controls a supply of electric power to the other communication device, wherein the output control section supplies no power to the other communication device when the first detection section detects the connection of the electric device.

    摘要翻译： 一种与另一通信设备建立通信并通过传输信道向另一通信设备提供电力的通信设备，所述设备包括产生电源电压的电源电压产生部分，检测连接的第一检测部分 除传送通道以外的其他通信装置的电气装置，以及控制对另一通信装置的电力供给的输出控制部，其中，所述输出控制部在所述第一检测部 检测电气设备的连接。

    Bicyclic compound, production and use thereof
    2.
    发明授权
    Bicyclic compound, production and use thereof 有权
    双环化合物，其生产和使用

    公开(公告)号：US08741943B2

    公开(公告)日：2014-06-03

    申请号：US13476454

    申请日：2012-05-21

    申请人： Mitsuru Shiraishi ,  Masanori Baba ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masaki Seto ,  Yuji Iizawa

    发明人： Mitsuru Shiraishi ,  Masanori Baba ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masaki Seto ,  Yuji Iizawa

    IPC分类号： C07D403/02 ,  A61K31/4178

    CPC分类号： A61K31/4196 ,  A61K31/395 ,  A61K31/4178 ,  C07D225/06 ,  C07D313/20 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12

    摘要： The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atoms; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

    摘要翻译： 本发明提供具有CCR拮抗剂活性，特别是CCR5拮抗剂活性的新的环状化合物及其用途。 本发明化合物由下式表示：其中，R 1为可被取代的5-至6-元环基; X1是债券等; 环A是可以被取代的5至6元环基团; 环B是可以被取代的8至10元环基团; X 2是1至4个原子的二价基团; Z1是二价环状环基等; Z2是键或类似物; R 2为氨基，可以被取代的含氮杂环基等，或其盐。

    HUMAN ANTIBODY CAPABLE OF INDUCING APOPTOSIS
    3.
    发明申请
    HUMAN ANTIBODY CAPABLE OF INDUCING APOPTOSIS 审中-公开
    人类抗体可诱导疫苗

    公开(公告)号：US20110117602A1

    公开(公告)日：2011-05-19

    申请号：US12743739

    申请日：2008-11-18

    申请人： Yuji Ito ,  Masanori Baba ,  Naomichi Arima ,  Yasuo Suda ,  Toshihiro Nakashima ,  Masaharu Torikai

    发明人： Yuji Ito ,  Masanori Baba ,  Naomichi Arima ,  Yasuo Suda ,  Toshihiro Nakashima ,  Masaharu Torikai

    IPC分类号： C07K16/30 ,  C07H21/04 ,  C12N15/63 ,  C12P21/00

    CPC分类号： C07K16/005 ,  C07K16/2833 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  G01N33/57484

    摘要： A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases.

    摘要翻译： 提供了与多种肿瘤细胞系（包括ATL细胞）具有特异性反应性并具有安全性和治疗功效以及所述抗体片段的人类抗体。 可以识别HLA-DR和bgr的人抗体和所述抗体的片段; 获得在肿瘤细胞表面表达的链​​。 特别地，发现所述抗体的scFv（双抗体）的二聚体可能在表达HLA-DR和bgr的细胞中诱导有效的凋亡; 链。 根据本发明获得的抗体和所述抗体的片段可用于检测试剂，诊断剂和用于保护或治疗包括ATL和/或病毒感染性疾病的癌症的药物。

    Tricyclic compound, process for producing the same, and use
    4.
    发明申请
    Tricyclic compound, process for producing the same, and use 审中-公开
    三环化合物，其制备方法和用途

    公开(公告)号：US20060178359A1

    公开(公告)日：2006-08-10

    申请号：US10544470

    申请日：2004-02-05

    申请人： Mitsuru Shiraishi ,  Masaki Seto ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masanori Baba

    发明人： Mitsuru Shiraishi ,  Masaki Seto ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masanori Baba

    IPC分类号： A61K31/55 ,  A61K31/4745 ,  C07D487/14

    CPC分类号： C07D471/04 ,  A61K31/4353 ,  A61K31/55

    摘要： A compound of the formula: wherein R1 is a 5- or 6-membered ring; Z1 is a 5- or 6-membered aromatic ring; Z2 is a group -Z2a-W2-Z2b-, wherein Z2a and Z2b are each O, S(O)q (wherein q is 0, 1 or 2), an imino group, or a bond; and W2 is an alkylene chain; W is a group represented by wherein R3 and R3′ are each a hydrogen atom, a lower alkyl group, or a lower alkoxy group; X is CH or N; n and n′ are each an integer of 0 or 1 to 4; m and m′ are each 1 or 2; Y is O, S(O)p (wherein p is 0, 1 or 2), CH2 or NR4 (wherein R4 is a hydrogen atom, a lower alkyl group, or a lower acyl group); and R2 is (1) an amino group, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide, or (2) a nitrogen-containing heterocyclic group which may contain a sulfur atom or an oxygen atom as the ring-constituting atom, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide; or a salt thereof. The compound exhibits excellent CCR antagonist activity against CCR5, and is useful as a prophylactic and/or therapeutic agent for HIV infection in human peripheral blood mononuclear cells, especially for AIDS.

    摘要翻译： 下式的化合物：其中R 1是5或6元环; Z 1是5或6元芳环; Z 2是基团-Z 2 O 2 -W 2 -Z 2b 2，其中Z 2a 和/或O 2各自为O，S（O）q q（其中q为0,1或2），亚氨基或键; 和W 2是亚烷基链; W是由R 3和R 3'表示的基团各自为氢原子，低级烷基或低级烷氧基; X是CH或N; n和n'各自为0或1〜4的整数; m和m'分别为1或2; Y是O，S（O）p（其中p是0,1或2），CH 2或NR 4（其中R' SUP> 4 是氢原子，低级烷基或低级酰基）; R 2是（1）可以将氮原子转化为季铵或氧化物的氨基，或者（2）可含有硫原子的含氮杂环基 或氧原子作为构成环的原子，其中氮原子可以转化为季铵或氧化物; 或其盐。 该化合物对CCR5表现出优异的CCR拮抗剂活性，并且可用作人外周血单核细胞（特别是AIDS）中HIV感染的预防和/或治疗剂。

    Therapeutic drug for adult T-cell leukemia
    9.
    发明授权
    Therapeutic drug for adult T-cell leukemia 有权
    成人T细胞白血病治疗药物

    公开(公告)号：US08765719B2

    公开(公告)日：2014-07-01

    申请号：US13120114

    申请日：2009-08-20

    申请人： Masanori Baba ,  Yuichi Hashimoto

    发明人： Masanori Baba ,  Yuichi Hashimoto

    IPC分类号： A61K31/12 ,  A61K31/166 ,  A61K31/11 ,  A61K31/695 ,  A61K31/352 ,  A61K31/095 ,  A61K31/135 ,  C07C49/83 ,  C07C325/02 ,  C07C233/65 ,  C07C47/546 ,  C07F7/08 ,  C07C225/18

    CPC分类号： C07C49/83 ,  A61K31/10 ,  A61K31/11 ,  A61K31/12 ,  A61K31/166 ,  A61K31/352 ,  A61K31/695

    摘要： An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, wherein R1 is H, OH, an alkoxy group, an acyl group, or a thioacyl group, R2 is an acyl group, a thioacyl group, CONR7R8, or CSNR7R8 (R7 and R8 being each independently H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group), or R1 and R2 together may form a ring, X1 and X2 may be the same or different and are each —CR3R4—, —SiR3R4— or oxygen, and R3 and R4 may be the same or different and are each an alkyl group containing 1 to 6 carbon atoms.

    摘要翻译： 目的是提供一种具有ATL细胞特异性抗肿瘤作用的成人T细胞白血病的新型治疗药物。 根据本发明的成人T细胞白血病的治疗药物的特征在于含有式I化合物或其前体药物，其中R1是H，OH，烷氧基，酰基或硫代酰基，R2 是酰基，硫代酰基，CONR7R8或CSNR7R8（R7和R8各自独立地为H，含有1至3个碳原子的烷基或苯基），或者R1和R2一起可以形成环，X1和 X2可以相同或不同，各自为-CR 3 R 4 - ， - SiR 3 R 4 - 或氧，R 3和R 4可以相同或不同，并且各自为含有1至6个碳原子的烷基。