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公开(公告)号:US4925934A
公开(公告)日:1990-05-15
申请号:US317322
申请日:1989-03-01
申请人: Masatoshi Taniguchi , Michio Sasaoka , Kiyotoshi Matsumura , Ichiro Kawahara , Kenji Kaze , Daisuke Suzuki , Akihiro Shimabayashi
发明人: Masatoshi Taniguchi , Michio Sasaoka , Kiyotoshi Matsumura , Ichiro Kawahara , Kenji Kaze , Daisuke Suzuki , Akihiro Shimabayashi
IPC分类号: C07D499/87 , C07D499/00 , C07D499/08 , C07D499/86 , C07D499/897
CPC分类号: C07D499/00 , Y02P20/55
摘要: The invention provides a process for preparing a .beta.-lactam derivative represented by the formula ##STR1## the process comprising reacting a .beta.-lactam derivative represented by the following formula (II) and having a protected carboxyl group with a cresol; ##STR2## wherein R represents a benzyl group having an electron-donating group as a substituent on the phenyl ring, a diphenylmethyl group which may have an electron-donating group as a substituent on the phenyl ring or a tert-butyl group.
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公开(公告)号:US4912213A
公开(公告)日:1990-03-27
申请号:US241186
申请日:1988-09-07
申请人: Masatoshi Taniguchi , Michio Sasaoka , Kiyotoshi Matsumura , Ichiro Kawahara , Kenji Kase , Daisuke Suzuki , Shigeru Torii , Hideo Tanaka , Motoaki Tanaka , Akira Nakai
发明人: Masatoshi Taniguchi , Michio Sasaoka , Kiyotoshi Matsumura , Ichiro Kawahara , Kenji Kase , Daisuke Suzuki , Shigeru Torii , Hideo Tanaka , Motoaki Tanaka , Akira Nakai
IPC分类号: C07D499/87 , B01J23/14 , B01J27/135 , C07B61/00 , C07D499/00 , C07D499/86 , C07D499/897
CPC分类号: C07D499/00 , Y02P20/55
摘要: The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.
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公开(公告)号:US4906623A
公开(公告)日:1990-03-06
申请号:US172937
申请日:1988-03-25
IPC分类号: C07D501/48 , A61K31/545 , C07D451/06 , C07D501/38 , C07D501/46 , C07D501/57
CPC分类号: C07D501/46
摘要: A cephalosporin compound substituted by imidazolium ring in 3-position of cephem having the following formula (I), and pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 is an organic residue known in .beta.-lactam antibiotics, R.sup.2 is hydrogen atom or methoxy, n is 0 or 1, A is a nitrogen-containing group constituting imidazolium ring, is useful as an agent for preventing and treating bacterial infections.
摘要翻译: 由具有下式(I)的头孢烯3位的咪唑啉环取代的头孢菌素化合物及其药学上可接受的盐,其中R1是β-内酰胺抗生素中已知的有机残基,R2是氢原子 或甲氧基,n为0或1,A为构成咪唑鎓环的含氮基团,可用作预防和治疗细菌感染的药剂。
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公开(公告)号:US6063918A
公开(公告)日:2000-05-16
申请号:US889048
申请日:1997-07-07
申请人: Michio Sasaoka , Daisuke Suzuki , Delsoo Suh , Yoshihisa Tokumaru
发明人: Michio Sasaoka , Daisuke Suzuki , Delsoo Suh , Yoshihisa Tokumaru
IPC分类号: C07D513/04 , A61K31/54 , A61P31/04 , C07D205/08 , C07D498/04 , C07D501/00 , C07D507/08
CPC分类号: C07D205/08 , C07D501/00 , Y02P20/55
摘要: A process for preparing a 2-isocephem derivative characterized in that a thioacetic acid derivative which itself is basic or a mixture of a base and a thioacetic acid derivative is caused to act on a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by the general formula (1) in a water-containing organic solvent to obtain a 3-halomethyl-2-isocephem derivative represented by the general formula (2), and a process for preparing a 2-oxaisocephem derivative characterized in that a base is caused to act on a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by the general formula (1) in a water-containing organic solvent to obtain a 3-halomethyl-2-oxaisocephem derivative represented by the general formula (3) ##STR1## wherein R.sup.1 is a hydrogen atom, amino or protected amino, R.sup.2 is a hydrogen atom or lower alkoxyl, R.sup.1 and R.sup.2, when taken together, form a cyclic amino protecting group, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, W is a leaving group, and X and Y are the same or different and are each a halogen atom.
摘要翻译: 制备2-异头孢烯衍生物的方法,其特征在于使本身为碱性的硫代乙酸衍生物或碱和硫代乙酸衍生物的混合物作用于2-氮杂环丁烷基-3,4-二卤代-2-丁烯酸 在含水有机溶剂中由通式(1)表示的酸化合物,得到由通式(2)表示的3-卤代甲基-2-异头孢烯衍生物及其制备方法,其特征在于, 在含水有机溶剂中使碱作用于由通式(1)表示的2-氮杂环丁烷基-3,4-二卤代-2-丁烯酸化合物,得到3-卤代甲基-2-氧代硫代衍生物 通式(3)其中R 1为氢原子,氨基或被保护的氨基,R 2为氢原子或低级烷氧基,R 1和R 2一起形成环状氨基保护基,R 3为氢原子或羧酸 酸保护基,W是离去基团,X a nd Y相同或不同,各自为卤素原子。
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公开(公告)号:US5688942A
公开(公告)日:1997-11-18
申请号:US732446
申请日:1996-11-06
申请人: Michio Sasaoka , Daisuke Suzuki , Delsoo Suh , Yoshihisa Tokumaru
发明人: Michio Sasaoka , Daisuke Suzuki , Delsoo Suh , Yoshihisa Tokumaru
IPC分类号: C07D513/04 , A61K31/54 , A61P31/04 , C07D205/08 , C07D498/04 , C07D501/00 , C07D507/08
CPC分类号: C07D205/08 , C07D501/00 , Y02P20/55
摘要: A process for preparing a 2-isocephem derivative characterized in that a thioacetic acid derivative which itself is basic or a mixture of a base and a thioacetic acid derivative is caused to act on a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by the general formula (1) in a water-containing organic solvent to obtain a 3-halomethyl-2-isocephem derivative represented by the general formula (2), and a process for preparing a 2-oxaisocephem derivative characterized in that a base is caused to act on a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by the general formula (1) in a water-containing organic solvent to obtain a 3-halomethyl-2-oxaisocephem derivative represented by the general formula (3) ##STR1## wherein R.sup.1 is a hydrogen atom, amino or protected amino, R.sup.2 is a hydrogen atom or lower alkoxyl, R.sup.1 and R.sup.2, when taken together, form a cyclic amino protecting group, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, W is a leaving group, and X and Y are the same or different and are each a halogen atom ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and X are the same as above, ##STR3## wherein R.sup.1, R.sup.2, R.sup.3 and X are the same as above.
摘要翻译: PCT No.PCT / JP96 / 00538 Sec。 371日期:1996年11月6日 102(e)日期1996年11月6日PCT 1996年3月6日PCT公布。 公开号WO96 / 28453 日期1996年9月19日制备2-异头孢烯衍生物的方法,其特征在于使本身为碱性的硫代乙酸衍生物或碱和硫代乙酸衍生物的混合物作用于2-氮杂环丁烷基-3,4- 由通式(1)表示的二卤代-2-丁烯酸化合物在含水有机溶剂中得到由通式(2)表示的3-卤代甲基-2-异头孢烯衍生物,以及制备2- 恶唑磺酸衍生物,其特征在于使碱在含水有机溶剂中作用于由通式(1)表示的2-氮杂环丁烷基-3,4-二卤代-2-丁烯酸化合物,得到3-卤代甲基 - 由通式(3)表示的2-氧代硫代衍生物无或被保护的氨基,R2是氢原子或低级烷氧基,R1和R2一起形成环状氨基保护基,R3是氢原子或羧酸保护基 组,W是离职小组,X和Y是sam e或不同,各自为卤素原子,其中R1,R2,R3和X与上述相同,其中R1,R2,R3和X与上述相同。
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公开(公告)号:US6011151A
公开(公告)日:2000-01-04
申请号:US732444
申请日:1996-11-06
申请人: Sigeru Torii , Hideo Tanaka , Michio Sasaoka , Yutaka Kameyama , Daisuke Suzuki
发明人: Sigeru Torii , Hideo Tanaka , Michio Sasaoka , Yutaka Kameyama , Daisuke Suzuki
IPC分类号: C07D205/08 , C07D205/085 , C07D205/09 , C07D205/095
CPC分类号: C07D205/08 , C07D205/085 , C07D205/09 , C07D205/095 , Y02P20/55
摘要: A process for preparing a .beta.-lactam halide compound represented by the formula (2) characterized by halogenating the allenyl group of an allenyl .beta.-lactam compound represented by the formula (1) with a cupric halide and a metal halide to obtain the .beta.-lactam halide compound ##STR1## wherein R.sup.1 is a hydrogen atom or amino or protected amino, R.sup.2 is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, or lower alkyl having a hydroxyl group or protected hydroxyl group as a substituent, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, and R.sup.4 is a hydrocarbon group which may have a substituent, or the group --S--S(O)n-Ar, n being 0 to 2, Ar being aryl which may have a substituent ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as defined above, X and Y are each halogen atom.
摘要翻译: PCT No.PCT / JP96 / 00489 Sec。 371日期:1996年11月6日 102(e)日期1996年11月6日PCT 1996年3月1日PCT公布。 WO96 / 28421 PCT出版物 日本1996年9月19日制备式(2)表示的β-内酰胺化合物化合物的制备方法,其特征在于用卤化铜和金属卤化物卤化由式(1)表示的烯丙基β-内酰胺化合物的全烯基 得到其中R1为氢原子或氨基或被保护的氨基,R2为氢原子,卤素原子,低级烷氧基,低级酰基或具有羟基或被保护的羟基作为取代基的低级烷基的β-内酰胺化合物, R3为氢原子或羧酸保护基,R4为可具有取代基的烃基,或-SS(O)n-Ar,n为0〜2,Ar为可具有取代基的芳基, R1,R2,R3和R4与上述定义相同,X和Y各自为卤素原子。
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公开(公告)号:US5770729A
公开(公告)日:1998-06-23
申请号:US530292
申请日:1996-01-22
申请人: Michio Sasaoka , Daisuke Suzuki , Takashi Shiroi
发明人: Michio Sasaoka , Daisuke Suzuki , Takashi Shiroi
IPC分类号: C07B33/00 , C07B41/06 , C07C45/40 , C07C46/04 , C07C51/34 , C07C323/12 , C07C323/20 , C07C323/52 , C07C323/60 , C07D205/095 , C07D205/10 , C07D403/04 , C07D513/04 , C07J1/00 , C07J13/00 , C07J71/00 , C07B31/00
CPC分类号: C07D403/04 , C07B33/00 , C07B41/06 , C07C323/12 , C07C323/20 , C07C323/52 , C07C323/60 , C07C45/40 , C07C46/04 , C07C51/34 , C07D205/095 , C07D205/10 , C07D513/04 , C07J1/0011 , C07J13/007 , C07J71/0005
摘要: The present invention provides an ozonide reducing agent for use in the ozonolysis reaction of an organic compound, the ozonide reducing agent finding wide applications, and being safe and inexpensive from a commercial viewpoint and easy to treat for disposal. The ozonide reducing agent of the invention is a compound wherein sulfur has, at both ends of its molecule, a hydrocarbon residue substituted by a polar functional group.
摘要翻译: PCT No.PCT / JP94 / 02224 Sec。 371日期1996年1月22日 102(e)日期1996年1月22日PCT 1994年12月26日PCT公布。 公开号WO95 / 18082 日期1995年7月6日本发明提供了一种用于有机化合物的臭氧分解反应的臭氧化物还原剂,该臭氧化物还原剂广泛应用,并且从商业观点来看是安全和便宜的,并且易于处理以便处理。 本发明的臭氧化物还原剂是其分子的两端具有被极性官能团取代的烃残基的化合物。
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公开(公告)号:US10965145B2
公开(公告)日:2021-03-30
申请号:US16213026
申请日:2018-12-07
申请人: Daisuke Suzuki , Takafumi Goto , Kensuke Kuroda
发明人: Daisuke Suzuki , Takafumi Goto , Kensuke Kuroda
摘要: A charge control device for controlling charging of a secondary battery by using a current limit function of an external power supply includes: a charge control element arranged to be connected in series between the external power supply and the secondary battery; a constant current control unit configured to control an output current of the charge control element to be constant; a constant voltage control unit configured to control an output voltage of the charge control element to be constant; and an ON state setting unit configured to set the charge control element to an ON state, wherein the charge control element includes a control terminal to which a control signal for controlling the output current and the output voltage is input, and is composed of a single output element.
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公开(公告)号:US09391772B2
公开(公告)日:2016-07-12
申请号:US14115251
申请日:2011-06-02
申请人: Daisuke Suzuki
发明人: Daisuke Suzuki
CPC分类号: H04L9/0866 , G06F12/14 , G06F21/50 , G06F21/70 , G06F2221/21 , G11B20/00086 , H04L9/3278
摘要: In initial generation (for example, shipping from the factory), a security device generates an identifier w specific to the security device, with the PUF technology, generates key information k (k=HF(k)) from the identifier w, generates encrypted confidential information x by encrypting (x=Enc(mk, k)) confidential information mk with the key information k, and stores the encrypted confidential information x and an authentication code h (h=HF′(k)) of the key information k, in a nonvolatile memory. In operation, the security device generates the identifier w with the PUF technology, generates the key information k from the identifier w, and decrypts the encrypted confidential information x with the key information k. At a timing where the identifier w is generated in the operation, the security device checks whether the current operating environment has largely changed from the initial generation (S311). If a change in operating environment is detected (S311→S312), the security device conducts a reset-up process (S312 to S315) of an authentication code h which is confidential information, and the encrypted confidential information x.
摘要翻译: 在初始阶段(例如,出厂时),安全设备生成特定于安全设备的标识符w,利用PUF技术,从标识符w生成密钥信息k(k = HF(k)),生成加密 机密信息x通过用密钥信息k加密(x = Enc(mk,k))机密信息mk,并且将加密的机密信息x和密钥信息k的认证码h(h = HF'(k))存储 ,在非易失性存储器中。 在操作中,安全设备利用PUF技术生成标识符w,从标识符w生成密钥信息k,并用密钥信息k对加密的机密信息进行解密。 在操作中生成标识符w的定时,安全装置检查当前的操作环境是否从初始生成发生了很大的变化(S311)。 如果检测到操作环境发生变化(S311→S312),则安全装置进行作为机密信息的认证码h的复位处理(S312〜S315)和加密的机密信息x。
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公开(公告)号:US09197084B2
公开(公告)日:2015-11-24
申请号:US13748174
申请日:2013-01-23
IPC分类号: H02J7/00
摘要: A charge controller includes a charge control circuit that, when detecting that a charging power supply is connected, controls the charging transistor to apply the charge current; a first and second control switch element connected in series between one terminal of a secondary battery and an external terminal; and a protection circuit that, when the secondary battery is over-discharged, turns off the first control switch element to stop discharge current and when deeply discharged, turns off the second control switch element. The protection circuit sends a charge inhibit signal to the charge control circuit when the secondary battery is deeply discharged, and while receiving the charge inhibit signal, the charge control circuit keeps the charging transistor off to prevent the charge current from flowing even if detecting that the charging power supply is connected.
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