公开(公告)号：US20210347823A1

公开(公告)日：2021-11-11

申请号：US17277783

申请日：2019-09-19

Applicant: Massachusetts Institute of Technology ,  Fundação Universidade Federal do ABC - UFABC (Federal University of ABC Foundation)

Inventor： Timothy Kuan-Ta Lu ,  Cesar de la Fuente Nunez ,  Vani Xavier de Oliveira Junior ,  Marcelo Der Torossian Torres

IPC: C07K7/08 ,  A61P31/04 ,  A61P31/10

Abstract: Described herein are methods of physicochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections.

公开(公告)号：US11026419B2

公开(公告)日：2021-06-08

申请号：US16349800

申请日：2017-11-20

Applicant: Massachusetts Institute of Technology

Inventor： T. Alan Hatton ,  Timothy Kuan-Ta Lu ,  Paul Brown ,  Cesar de la Fuente Nunez ,  Sahag Voskian

IPC: A61K9/00 ,  A01N33/04 ,  A01N25/02 ,  A01N37/18 ,  A01N59/20

Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.

公开(公告)号：US20190327964A1

公开(公告)日：2019-10-31

申请号：US16349800

申请日：2017-11-20

Applicant: Massachusetts Institute of Technology

Inventor： T. Alan Hatton ,  Timothy Kuan-Ta Lu ,  Paul Brown ,  Cesar de la Fuente Nunez ,  Sahag Voskian

IPC: A01N33/04 ,  A01N59/20 ,  A01N25/02 ,  A01N37/18

Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.

公开(公告)号：US20200009611A1

公开(公告)日：2020-01-09

申请号：US16482954

申请日：2018-02-05

Applicant: Massachusetts Institute of Technology

Inventor： Sahag Voskian ,  Cesar de la Fuente Nunez ,  T. Alan Hatton ,  Ryan Alex Shaw ,  Paul Brown

IPC: B05D1/00 ,  B01D53/02 ,  C02F1/467 ,  A01N25/04 ,  A01N59/06 ,  A01N59/16 ,  A01N59/18 ,  A01N59/20 ,  A61L29/08 ,  A61L29/16 ,  A61L29/14

Abstract: Disclosed are polymer-coated surfaces encapsulating task specific ionic liquids (ILs), IL complexes, or oils. Also disclosed are polymer-coated surfaces, wherein the polymer comprises ILs or neutral ethylene diamine compounds. Also disclosed are methods of antimicrobial treatment, metal remediation, and gas absorption using polymer coatings encapsulating ILs, IL complexes, and oils or polymer coatings comprising ILs and neutral ethylene diamine compounds.

公开(公告)号：US11045833B2

公开(公告)日：2021-06-29

申请号：US16482954

申请日：2018-02-05

Applicant: Massachusetts Institute of Technology

Inventor： Sahag Voskian ,  Cesar de la Fuente Nunez ,  T. Alan Hatton ,  Ryan Alex Shaw ,  Paul Brown

IPC: B05D1/00 ,  A01N25/04 ,  A01N59/06 ,  A01N59/16 ,  A01N59/18 ,  A01N59/20 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  B01D53/02 ,  C02F1/467 ,  C02F101/20

Abstract: Disclosed are polymer-coated surfaces encapsulating task specific ionic liquids (ILs), IL complexes, or oils. Also disclosed are polymer-coated surfaces, wherein the polymer comprises ILs or neutral ethylene diamine compounds. Also disclosed are methods of antimicrobial treatment, metal remediation, and gas absorption using polymer coatings encapsulating ILs, IL complexes, and oils or polymer coatings comprising ILs and neutral ethylene diamine compounds.