公开(公告)号：US20170073311A1

公开(公告)日：2017-03-16

申请号：US15270959

申请日：2016-09-20

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Niels Holten-Andersen ,  Scott Charles Grindy ,  Ken Kawamoto ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07D213/30 ,  A61K47/22 ,  C07F15/00

CPC分类号： C07D213/30 ,  A61K47/22 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/02 ,  C07F15/04 ,  C08G83/008

摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

摘要翻译： 本公开提供通过过渡金属配体（例如，式（A）的Pd（II） - ，Ni（II） - 或Fe（II） - 配体）配位和结合形成的纳米结构（例如纳米球和纳米桨轮） 自组装 本公开还提供包括通过二价连接体Y连接的纳米结构的超分子复合物。所提供的超分子复合物能够形成凝胶（例如水凝胶）。 凝胶是超标记物，表现出优异的机械性能，而不牺牲自愈，显示出高的鲁棒性和储能模量。 本公开进一步提供包含纳米结构或超分子复合物和任选的试剂（例如小分子）的组合物（例如，凝胶），其中超分子复合物的纳米结构和纳米结构部分可以包封并缓慢释放试剂。 纳米结构，超分子复合物和组合物可用于将药物递送至受试者，组织或细胞，作为超吸收材料，以及治疗疾病（例如，遗传性疾病，增殖性疾病（例如癌症或良性） 肿瘤），血液疾病，神经系统疾病，胃肠道疾病（如肝脏疾病），脾脏疾病，呼吸系统疾病（如肺部疾病），疼痛状况，泌尿生殖器疾病，肌肉骨骼疾病，感染性疾病，炎性疾病，自身免疫性疾病，精神疾病 ，或代谢紊乱）。

公开(公告)号：US09932315B2

公开(公告)日：2018-04-03

申请号：US15502678

申请日：2015-08-07

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07D233/16

CPC分类号： C07D233/16

摘要： Persistent carbene adducts and methods of forming the same are generally described, as well as compositions comprising the persistent carbene adduct. In some embodiments, methods are provided comprising heating a persistent carbene to relatively high temperatures to convert the persistent carbene into a persistent carbene-carbodiimide adduct. In certain embodiments, the percent of the persistent carbene that is converted to the persistent carbene-carbodiimide adduct is relatively high (e.g., at least about 50%). In some embodiments, the persistent carbene-carbodiimide adducts formed via the methods described herein may be relatively stable. Compositions comprising the persistent carbene-carbodiimide adducts of the present invention may be useful for applications involving catalysis, organometallic chemistry, sensing, and surface functionalization, amongst others.

公开(公告)号：US09908901B2

公开(公告)日：2018-03-06

申请号：US15183730

申请日：2016-06-15

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07F7/08

CPC分类号： C07F7/0827 ,  C07F7/081 ,  C07F7/0814

摘要： Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

公开(公告)号：US20170233349A1

公开(公告)日：2017-08-17

申请号：US15502678

申请日：2015-08-07

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07D233/16

CPC分类号： C07D233/16

摘要： Persistent carbene adducts and methods of forming the same are generally described, as well as compositions comprising the persistent carbene adduct. In some embodiments, methods are provided comprising heating a persistent carbene to relatively high temperatures to convert the persistent carbene into a persistent carbene-carbodiimide adduct. In certain embodiments, the percent of the persistent carbene that is converted to the persistent carbene-carbodiimide adduct is relatively high (e.g., at least about 50%). In some embodiments, the persistent carbene-carbodiimide adducts formed via the methods described herein may be relatively stable. Compositions comprising the persistent carbene-carbodiimide adducts of the present invention may be useful for applications involving catalysis, organometallic chemistry, sensing, and surface functionalization, amongst others.

公开(公告)号：US10023536B2

公开(公告)日：2018-07-17

申请号：US15270959

申请日：2016-09-20

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Niels Holten-Andersen ,  Scott Charles Grindy ,  Ken Kawamoto ,  Aleksandr V. Zhukhovitskiy

IPC分类号： A61K47/22 ,  C07D213/30 ,  C07F15/00 ,  C07F15/02 ,  C07F15/04 ,  C08G83/00

摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

公开(公告)号：US20160355484A1

公开(公告)日：2016-12-08

申请号：US15171998

申请日：2016-06-02

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07D233/20 ,  C07D233/06 ,  C08F292/00 ,  C07D403/14

CPC分类号： C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C07D403/14 ,  C08F292/00

摘要： Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

摘要翻译： 提供了包含持续卡宾的制品和方法以及相关组合物。 在一些实施方案中，持久卡宾可以与基底的一部分（例如，基底上的表面的至少一部分）相关联。 在某些实施方案中，持久卡宾与底物的缔合可用于影响底物的某些性质（例如，表面化学，稳定性）。 在一些情况下，持续卡宾可以在与一部分底物缔合后进行官能化。 在一些实施方案中，持久卡宾和至少一种次级化合物可与底物的一部分缔合。 本发明的制品和方法可用于涉及电子学，感测，微细加工，纳米技术，仿制和药物递送等应用。

公开(公告)号：US09382210B2

公开(公告)日：2016-07-05

申请号：US14210187

申请日：2014-03-13

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07D233/20 ,  C07D403/10 ,  C07D403/14

CPC分类号： C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C07D403/14 ,  C08F292/00

摘要： Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

摘要翻译： 提供了包含持续卡宾的制品和方法以及相关组合物。 在一些实施方案中，持久卡宾可以与基底的一部分（例如，基底上的表面的至少一部分）相关联。 在某些实施方案中，持久卡宾与底物的缔合可用于影响底物的某些性质（例如，表面化学，稳定性）。 在一些情况下，持续卡宾可以在与一部分底物缔合后进行官能化。 在一些实施方案中，持久卡宾和至少一种次级化合物可与底物的一部分缔合。 本发明的制品和方法可用于涉及电子学，感测，微细加工，纳米技术，仿制和药物递送等应用。

公开(公告)号：US20150225438A1

公开(公告)日：2015-08-13

申请号：US14617747

申请日：2015-02-09

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Niels Holten-Andersen ,  Scott Charles Grindy ,  Ken Kawamoto ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07F15/00 ,  A61K47/22

CPC分类号： C07D213/30 ,  A61K47/22 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/02 ,  C07F15/04 ,  C08G83/008

摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

摘要翻译： 本公开提供通过过渡金属配体（例如，式（A）的Pd（II） - ，Ni（II） - 或Fe（II） - 配体）配位和结合形成的纳米结构（例如纳米球和纳米桨轮） 自组装 本公开还提供包括通过二价连接体Y连接的纳米结构的超分子复合物。所提供的超分子复合物能够形成凝胶（例如水凝胶）。 凝胶是超标记物，表现出优异的机械性能，而不牺牲自愈，显示出高的鲁棒性和储能模量。 本公开进一步提供包含纳米结构或超分子复合物和任选的试剂（例如小分子）的组合物（例如，凝胶），其中超分子复合物的纳米结构和纳米结构部分可以包封并缓慢释放试剂。 纳米结构，超分子复合物和组合物可用于将药物递送至受试者，组织或细胞，作为超吸收材料，以及治疗疾病（例如，遗传性疾病，增殖性疾病（例如癌症或良性） 肿瘤），血液疾病，神经系统疾病，胃肠道疾病（如肝脏疾病），脾脏疾病，呼吸系统疾病（如肺部疾病），疼痛状况，泌尿生殖器疾病，肌肉骨骼疾病，感染性疾病，炎性疾病，自身免疫性疾病，精神疾病 ，或代谢紊乱）。

公开(公告)号：US09815793B2

公开(公告)日：2017-11-14

申请号：US15171998

申请日：2016-06-02

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C08F292/00 ,  C07D403/14

CPC分类号： C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C07D403/14 ,  C08F292/00

摘要： Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

公开(公告)号：US20160289248A1

公开(公告)日：2016-10-06

申请号：US15183730

申请日：2016-06-15

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

IPC分类号： C07F7/08

CPC分类号： C07F7/0827 ,  C07F7/081 ,  C07F7/0814

摘要： Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.