公开(公告)号：US20180353435A1

公开(公告)日：2018-12-13

申请号：US16002965

申请日：2018-06-07

Applicant: Massachusetts Institute of Technology

Inventor： Michael Mitchell ,  Amanda Chung ,  Pedro P. G. Guimaraes ,  Omar F. Khan ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K9/51 ,  C12N15/113

CPC classification number: A61K9/5146 ,  A61K9/5123 ,  A61K31/7088 ,  A61K47/544 ,  A61K47/60 ,  A61K47/6935 ,  A61K48/00 ,  A61P35/00 ,  C07C215/14 ,  C07F9/106 ,  C12N15/1138 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32

Abstract: The present invention provides compositions (e.g., nanoparticles) comprising a conjugated polyethyleneimine (PEI) polymer (a “conjugated lipomer”), or a pharmaceutically acceptable salt thereof, and a lipid-PEG conjugate, wherein the conjugated lipomer of Formula (I) contains one or more groups of the formula (iii). Compositions of the invention are useful for the delivery of active agents, for example, for the treatment of disease.