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公开(公告)号：US20190167795A1
公开(公告)日：2019-06-06
申请号：US16181109
申请日：2018-11-05
Applicant: Massachusetts Institute of Technology
Inventor： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC: A61K47/22 , C12N15/113 , A61K47/69 , C07D273/08 , A61K47/59 , A61K47/54 , A61K47/34 , C07D295/084 , A61K9/127 , C07D273/00 , C07D257/02 , C08G73/10 , A61K9/00
Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
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公开(公告)号：US20160206740A1
公开(公告)日：2016-07-21
申请号：US14995842
申请日：2016-01-14
Applicant: Massachusetts Institute of Technology
Inventor： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC: A61K47/22 , C07D273/00 , C07D295/084 , C12N15/113 , A61K9/127
CPC classification number: A61K47/22 , A61K9/0019 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/59 , A61K47/6907 , A61K47/6911 , A61K47/6921 , C07D257/02 , C07D273/00 , C07D273/08 , C07D295/084 , C08G73/10 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/32
Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
Abstract translation: 本发明提供含有一个或多个式（ⅲ）基团的本发明共轭聚乙烯亚胺（PEI）聚合物和共轭氮杂 - 大环化合物（统称为“共轭脂族”或“脂聚合物”）：其中R3和R4定义如上 这里。 还提供了包含本发明的共轭脂族物的组合物，以及制备和使用方法。
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公开(公告)号：US20140228715A1
公开(公告)日：2014-08-14
申请号：US14116628
申请日：2012-05-14
Inventor： Avraham D. Schroeder , Carlo Giovanni Traverso , Baris E. Polat , Kathryn A. Whitehead , Daniel G. Anderson , Robert S. Langer, Jr. , Carl Magnus Schoellhammer , Daniel Blankschtein
IPC: A61N7/00
CPC classification number: A61N7/00 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/14546 , A61B5/4839 , A61M31/002 , A61M37/0092
Abstract: A method of delivering a substance includes providing a substance at a location in a gastrointestinal (GI) tract, excluding a buccal membrane, of a biological body; and applying ultrasonic waves, having a frequency between about 20 kHz and about 10 MHz, at the location. The method can include storing the substance in at least one reservoir and exposing a medium within or of the GI tract to the substance. The method can further include delivering a device into the GI tract, the device including at least one ultrasound transducer and circuitry; powering the at least one ultrasound transducer and circuitry from within the device; and driving the at least one ultrasound transducer, using the circuitry, in a manner causing the at least one ultrasound transducer to emit ultrasonic waves to a medium within or of the GI tract.
Abstract translation: 递送物质的方法包括在生物体的胃肠（GI）道（不包括颊膜）的位置处提供物质; 并且在该位置施加具有约20kHz至约10MHz之间的频率的超声波。 该方法可以包括将物质储存在至少一个储存器中并将GI道内或介质中的介质暴露于物质。 该方法还可以包括将装置递送到胃肠道，该装置包括至少一个超声换能器和电路; 为设备内的至少一个超声换能器和电路供电; 以及使得所述至少一个超声换能器以使得所述至少一个超声换能器向胃肠道内或胃肠道内的介质发射超声波的方式来驱动所述至少一个超声换能器。
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Patent Agency Ranking
公开(公告)号：US20210260195A1
公开(公告)日：2021-08-26
申请号：US17122068
申请日：2020-12-15
Applicant: Massachusetts Institute of Technology
Inventor： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC: A61K47/22 , A61K47/54 , A61K47/59 , A61K47/69 , C07D257/02 , C07D273/08 , A61K9/00 , A61K47/34 , C08G73/10 , A61K9/127 , C07D273/00 , C07D295/084 , C12N15/113
Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
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公开(公告)号：US10117934B2
公开(公告)日：2018-11-06
申请号：US14995842
申请日：2016-01-14
Applicant: Massachusetts Institute of Technology
Inventor： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC: C07D257/02 , A61K47/22 , C07D273/08 , C08G73/10 , A61K9/00 , A61K47/34 , A61K9/127 , C07D273/00 , C07D295/084 , C12N15/113 , A61K47/54 , A61K47/59 , A61K47/69
Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
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公开(公告)号：US10933139B2
公开(公告)日：2021-03-02
申请号：US16181109
申请日：2018-11-05
Applicant: Massachusetts Institute of Technology
Inventor： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC: A61K47/22 , A61K47/54 , A61K47/59 , A61K47/69 , C07D257/02 , C07D273/08 , A61K9/00 , A61K47/34 , C08G73/10 , A61K9/127 , C07D273/00 , C07D295/084 , C12N15/113
Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
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公开(公告)号：US10814115B2
公开(公告)日：2020-10-27
申请号：US13728300
申请日：2012-12-27
Inventor： Carlo Giovanni Traverso , Avraham D. Schroeder , Baris Erinc Polat , Carl Magnus Schoellhammer , Daniel Blankschtein , Daniel G. Anderson , Robert S. Langer
Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.
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公开(公告)号：US20130165772A1
公开(公告)日：2013-06-27
申请号：US13728300
申请日：2012-12-27
Inventor： Carlo Giovanni Traverso , Avraham D. Schroeder , Baris Erinc Polat , Carl Magnus Schoellhammer , Daniel Blankschtein , Daniel G. Anderson , Robert S. Langer
Abstract: The present disclosure provides devices and uses thereof A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.
Abstract translation: 本公开提供了装置及其用途。本文公开的装置包括适于从装置突出的多个微针。 在一些实施例中，将装置的尺寸设计和构造为承载有效载荷，使得有效载荷可以在与微针相互作用之后被递送到受试者的内部组织或通过血管的壁。 在一些实施方案中，装置可用于口服或静脉内施用。 在一些实施例中，装置可用于植入，例如阴道，直肠，尿道或膀胱栓剂或子宫托。
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