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公开(公告)号：US11120983B2
公开(公告)日：2021-09-14
申请号：US16876527
申请日：2020-05-18
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
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公开(公告)号：US10236172B2
公开(公告)日：2019-03-19
申请号：US15645147
申请日：2017-07-10
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
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公开(公告)号：US20140257236A1
公开(公告)日：2014-09-11
申请号：US14280477
申请日：2014-05-16
Applicant: Massachusetts Institute of Technology
Inventor： Brian D. Hemond , Ian W. Hunter , Andrew J. Taberner , Dawn M. Wendell , N. Catherine Hogan
IPC: A61M5/30
CPC classification number: A61M5/30 , A61M5/24 , A61M5/46 , A61M5/486 , A61M2205/3331 , A61M2205/3358 , A61M2205/3368 , A61M2205/50 , A61M2205/8287
Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
Abstract translation: 通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。 当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。 注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，以及（ii）第二时间段，其中物质的剩余体积为 在第二注射压力下注射。 可以确定物质的粘度，并计算基于粘度注入物质的压力。 物质可以通过使用计算的压力与输送装置一起注入。
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公开(公告)号：US20160197542A1
公开(公告)日：2016-07-07
申请号：US15066868
申请日：2016-03-10
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
CPC classification number: H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
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公开(公告)号：US08992466B2
公开(公告)日：2015-03-31
申请号：US13708303
申请日：2012-12-07
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
CPC classification number: H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
Abstract translation: 用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。 称为洛伦兹力致动器的致动器包括固定磁体组件和动圈组件。 线圈组件移动具有位于储存器内的端部的活塞。 致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。 力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。 有利地，致动器可以根据电气输入沿不同方向移动。
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Patent Agency Ranking
公开(公告)号：US20130102957A1
公开(公告)日：2013-04-25
申请号：US13708303
申请日：2012-12-07
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
IPC: A61M5/30
CPC classification number: H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
Abstract translation: 用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。 称为洛伦兹力致动器的致动器包括固定磁体组件和移动线圈组件。 线圈组件移动具有位于储存器内的端部的活塞。 致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。 力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。 有利地，致动器可以根据电气输入沿不同方向移动。
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公开(公告)号：US10658169B2
公开(公告)日：2020-05-19
申请号：US16351700
申请日：2019-03-13
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
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公开(公告)号：US10326347B2
公开(公告)日：2019-06-18
申请号：US15066868
申请日：2016-03-10
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
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公开(公告)号：US20170065769A1
公开(公告)日：2017-03-09
申请号：US15338038
申请日：2016-10-28
Applicant: Massachusetts Institute of Technology
Inventor： Brian D. Hemond , Ian W. Hunter , Andrew J. Taberner , Dawn M. Wendell , N. Catherine Hogan
CPC classification number: A61M5/30 , A61M5/24 , A61M5/46 , A61M5/486 , A61M2205/3331 , A61M2205/3358 , A61M2205/3368 , A61M2205/50 , A61M2205/8287
Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
Abstract translation: 通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。 当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。 注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，和（ii）第二时间段，其中物质的剩余体积为 在第二注射压力下注射。 可以确定物质的粘度，并计算基于粘度注入物质的压力。 物质可以通过使用计算的压力与输送装置一起注入。
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公开(公告)号：US09308326B2
公开(公告)日：2016-04-12
申请号：US14490126
申请日：2014-09-18
Applicant: Massachusetts Institute of Technology
Inventor： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
CPC classification number: H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
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