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    Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
    3.
    发明授权
    Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties 有权

    公开(公告)号：US10463276B2

    公开(公告)日：2019-11-05

    申请号：US15342718

    申请日：2016-11-03

    Applicant: Massachusetts Institute of Technology

    Inventor： Ian W. Hunter ,  Yi Chen

    IPC: A61B5/00 ,  A61B5/103 ,  A01G7/00 ,  G01N3/24 ,  G01N3/40 ,  A61B9/00

    Abstract: A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.

    Systems, Apparatus, and Methods for Spectral Imaging
    6.
    发明申请
    Systems, Apparatus, and Methods for Spectral Imaging 审中-公开

    公开(公告)号：US20180135970A1

    公开(公告)日：2018-05-17

    申请号：US15870920

    申请日：2018-01-13

    Applicant: Massachusetts Institute of Technology

    Inventor： Yi Chen Mazumdar ,  Ian W. Hunter

    IPC: G01B11/14 ,  G01J3/28 ,  G01J3/26

    CPC classification number: G01B11/14 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4535 ,  G06K9/00288 ,  G06K9/00677 ,  G06K9/00718 ,  G06K9/00771

    Abstract: A spectral imaging system includes an autocorrelator to generate different autocorrelations when the moving reflector in the autocorrelator is at different positions so as to reconstruct spectral images. The system also includes a position measurement system to measure the actual positions of the moving reflector when autocorrelations are taken. These actual locations, instead of the desired locations in conventional methods, are then used to reconstruct the spectral image. This approach can address the misalignment of the moving reflector from its desired location (due to external disturbances, slow actuator dynamics, and other factors) in conventional spectral imaging techniques and allow the development of high-resolution, high-stability, portable imaging spectrometers for the general public.

    INJECTION METHODS USING A SERVO-CONTROLLED NEEDLE-FREE INJECTOR
    9.
    发明申请
    INJECTION METHODS USING A SERVO-CONTROLLED NEEDLE-FREE INJECTOR 审中-公开
    使用伺服控制无针注射器的注射方法

    公开(公告)号：US20140257236A1

    公开(公告)日：2014-09-11

    申请号：US14280477

    申请日：2014-05-16

    Applicant: Massachusetts Institute of Technology

    Inventor： Brian D. Hemond ,  Ian W. Hunter ,  Andrew J. Taberner ,  Dawn M. Wendell ,  N. Catherine Hogan

    IPC: A61M5/30

    CPC classification number: A61M5/30 ,  A61M5/24 ,  A61M5/46 ,  A61M5/486 ,  A61M2205/3331 ,  A61M2205/3358 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/8287

    Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

    Abstract translation: 通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。 当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。 注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，以及（ii）第二时间段，其中物质的剩余体积为 在第二注射压力下注射。 可以确定物质的粘度，并计算基于粘度注入物质的压力。 物质可以通过使用计算的压力与输送装置一起注入。

    Wireless actuators
    10.
    发明授权
    Wireless actuators 有权

    公开(公告)号：US11892015B2

    公开(公告)日：2024-02-06

    申请号：US17284243

    申请日：2019-10-10

    Applicant: Massachusetts Institute of Technology

    Inventor： Seyed M. Mirvakili ,  Ian W. Hunter

    IPC: F15B15/10 ,  F15B21/06 ,  H01F1/44 ,  F15B15/20 ,  F15B15/14 ,  B25J9/14

    CPC classification number: F15B15/103 ,  F15B15/1485 ,  F15B21/065 ,  H01F1/445 ,  H01F1/447 ,  B25J9/142 ,  F15B2015/208 ,  F15B2211/885

    Abstract: A method of performing wireless actuation by inductive heating of magnetic particles. The method provides a bladder having an inner surface and an outer surface, the inner surface forming an interior area, the bladder configured to expand or retract so as to change an area of the interior area, (ii) a plurality of magnetic particles suspended in a fluid medium and disposed within the interior area, and (iii) a sleeve disposed on the outer surface of the bladder. The method excites the plurality of magnetic particles by application of an alternating magnetic field to which the particles reaction. The method causes, by the excited magnetic particles, a phase transition to the fluid medium within the interior area which causes the bladder to expand, such that the sleeve confining the bladder generates actuation from the expansion or retraction of the bladder.

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