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公开(公告)号：US11547347B2
公开(公告)日：2023-01-10
申请号：US16152785
申请日：2018-10-05
IPC分类号： A61B5/00 , A61B5/07 , A61B5/11 , H01L41/04 , H01L41/047 , H01L41/053 , H01L41/113 , H01L41/187 , H01L41/23 , H01L41/29 , H01L41/333 , G01L1/16 , G01L19/08 , G01L9/00
摘要： Improvements in ingestible electronics with the capacity to sense physiologic and pathophysiologic states have transformed the standard of care for patients. Yet despite advances in device development, significant risks associated with solid, non-flexible gastrointestinal transiting systems remain. Here, we disclose an ingestible, flexible piezoelectric device that senses mechanical deformation within the gastric cavity. We demonstrate the capabilities of the sensor in both in vitro and ex vivo simulated gastric models, quantified its key behaviors in the GI tract by using computational modeling, and validated its functionality in awake and ambulating swine. Our piezoelectric devices can safely sense mechanical variations and harvest mechanical energy inside the gastrointestinal tract for diagnosing and treating motility disorders and for monitoring ingestion in bariatric applications.
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公开(公告)号：US11783627B2
公开(公告)日：2023-10-10
申请号：US17163410
申请日：2021-01-30
发明人： Canan Dagdeviren , Farita Tasnim
CPC分类号： G06V40/166 , G06F3/012 , G06F3/017 , G06N20/00 , G06V40/172 , G06V40/174
摘要： A conformable sensor module may conform to skin of a user's face. The sensor module may include multiple piezoelectric strain sensors. The sensor module may measure mechanical strain of facial skin that occurs while the user makes facial gestures. To do so, the sensor module may take a time series of multiple measurements of strain of the user's facial skin at each of multiple locations on the user's face, while the user makes a facial gesture. The resulting spatiotemporal data regarding facial strain may be fed as an input into a trained machine learning algorithm. The trained machine learning algorithm may, based on this input, classify a facial gesture. A computer may determine content associated with the classification. The content may be outputted in audible or visual format. This may facilitate communication by patients with neuromuscular disorders who are unable to vocalize intelligible speech.
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公开(公告)号：US20210256246A1
公开(公告)日：2021-08-19
申请号：US17163410
申请日：2021-01-30
发明人： Canan Dagdeviren , Farita Tasnim
摘要： A conformable sensor module may conform to skin of a user's face. The sensor module may include multiple piezoelectric strain sensors. The sensor module may measure mechanical strain of facial skin that occurs while the user makes facial gestures. To do so, the sensor module may take a time series of multiple measurements of strain of the user's facial skin at each of multiple locations on the user's face, while the user makes a facial gesture. The resulting spatiotemporal data regarding facial strain may be fed as an input into a trained machine learning algorithm. The trained machine learning algorithm may, based on this input, classify a facial gesture. A computer may determine content associated with the classification. The content may be outputted in audible or visual format. This may facilitate communication by patients with neuromuscular disorders who are unable to vocalize intelligible speech.
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公开(公告)号：US20230397901A1
公开(公告)日：2023-12-14
申请号：US18458406
申请日：2023-08-30
发明人： Canan Dagdeviren , Lin Zhang
CPC分类号： A61B8/0825 , A61B8/466 , A61B8/4209 , A61B8/4477 , A61B8/4488 , A61B8/4472 , A61B8/5207
摘要： An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.
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公开(公告)号：US11779302B2
公开(公告)日：2023-10-10
申请号：US16658237
申请日：2019-10-21
发明人： Canan Dagdeviren , Lin Zhang
CPC分类号： A61B8/0825 , A61B8/4209 , A61B8/4477 , A61B8/4488 , A61B8/466 , A61B8/4472 , A61B8/5207
摘要： An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.
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公开(公告)号：US20210145608A1
公开(公告)日：2021-05-20
申请号：US16969142
申请日：2019-02-12
发明人： Hugh M. Herr , Kevin Mattheus Moerman , Dana Solav , Bryan James Ranger , Rebecca Steinmeyer , Stephanie Lai Ku , Canan Dagdeviren , Matthew Carney , German A. Prieto-Gomez , Xiang Zhang , Jonathan Randall Fincke , Micha Feigin-Almon , Brian W. Anthony, Ph.D. , Zixi Liu , Aaron Jaeger , Xingbang Yang
摘要： Devices and methods for obtaining external shapes and internal tissue geometries, as well as tissue behaviors, of a biological body segment are provided. A device for three-dimensional imaging of a biological body segment includes a structure configured to receive the biological body segment, the structure including a first array of imaging devices disposed about a perimeter of the device to capture side images of the biological body segment and a second array of imaging devices disposed at an end of the device to capture images of a distal portion of the biological body segment. The second array has a generally axial viewing angle relative to the perimeter. A controller is configured to generate a three-dimensional reconstruction of the biological body segment based on cross-correlation of captured images from the first and second arrays.
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公开(公告)号：US20210100460A1
公开(公告)日：2021-04-08
申请号：US17032699
申请日：2020-09-25
IPC分类号： A61B5/0205 , G01K13/00 , G01P15/08 , G01K7/00 , G01K1/14 , G01P15/18 , G01C19/00 , G01P1/00 , A61B5/00 , A61B5/0408 , A41D1/00 , A41D31/18
摘要： A conformable garment may fit snugly against, and may exert pressure against, skin in a region of a user's body. The garment may house multiple sensors that touch the user's skin. Each sensor may exposed to the user's skin through a hole in an inner surface of the garment. The garment may include elongated channels. Flexible, stretchable wiring may pass through a hollow central region of each channel. This wiring may provide electrical power to the sensors, and may enable wired communication between the sensors and a main hub. Each sensor may include an integrated chip and may be encapsulated in a waterproof material. Each sensor may output electrical signals that encode digital data and that are transmitted, via the wiring, to a main hub housed in the garment. The encapsulated sensors and the wiring may remain in the garment when the garment is washed.
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