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公开(公告)号：US20140302116A1
公开(公告)日：2014-10-09
申请号：US14201615
申请日：2014-03-07
IPC分类号： A61K9/70 , A61K31/713
CPC分类号： A61K45/06 , A61K31/7105 , A61L27/12 , A61L27/22 , A61L27/46 , A61L31/026 , A61L31/047 , A61L31/127 , A61L31/16 , A61L2400/12 , A61L2420/08
摘要： The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes a substrate; and a multilayer film coated on the substrate, wherein adjacent layers of the multilayer film are associated with one another via one or more non-covalent interactions, wherein the multilayer film comprises a first nucleic acid agent present at a loading density, and further wherein the multilayer film is characterized in that, when the structure is placed on a subject so that the multilayer film contacts cells, the first nucleic acid agent is released with a profile characterized by a feature selected from the group consisting of 1) being a burst-free release; 2) being a sustained release; and 3) exhibiting in vitro and/or in vivo biological effectiveness.
摘要翻译： 本发明尤其提供了多层膜涂料组合物，涂覆的基材及其方法。 在一些实施例中，结构包括基底; 以及涂覆在所述基底上的多层膜，其中所述多层膜的相邻层通过一种或多种非共价相互作用彼此相关联，其中所述多层膜包含以负载密度存在的第一核酸试剂，并且其中 多层膜的特征在于，当将结构放置在受试者上使得多层膜与细胞接触时，第一核酸试剂以具有选自以下的特征的轮廓被释放：1）是无突变的 发布; 2）持续释放; 和3）展现体外和/或体内生物学效力。
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2.发明授权公开(公告)号：US11590240B2
公开(公告)日：2023-02-28
申请号：US15739487
申请日：2016-06-23
摘要： Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders. In an embodiment, the conjugated polymer comprises poly (vinyl alcohol) covalently bound to ATRA through an ester linkage.
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