公开(公告)号：US10717769B2

公开(公告)日：2020-07-21

申请号：US16530047

申请日：2019-08-02

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane KA-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  A61N5/06 ,  C12N13/00 ,  G01N33/487 ,  A61K41/00 ,  G01N33/50 ,  A61K38/00

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

公开(公告)号：US10472399B2

公开(公告)日：2019-11-12

申请号：US15359875

申请日：2016-11-23

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  A61N5/06 ,  C12N13/00 ,  G01N33/487 ,  A61K41/00 ,  G01N33/50 ,  A61K38/00

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

公开(公告)号：US10882892B2

公开(公告)日：2021-01-05

申请号：US14817335

申请日：2015-08-04

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: A61K38/00 ,  A61K38/16 ,  A61P9/10 ,  A61P27/02 ,  C07K14/705 ,  A61K41/00 ,  A61N5/06 ,  C07K14/435 ,  G01N33/68

Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.

公开(公告)号：US11274128B2

公开(公告)日：2022-03-15

申请号：US16885457

申请日：2020-05-28

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  A61N5/06 ,  C12N13/00 ,  G01N33/487 ,  A61K41/00 ,  G01N33/50 ,  A61K38/00

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

公开(公告)号：US20170088590A1

公开(公告)日：2017-03-30

申请号：US15359875

申请日：2016-11-23

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  A61N5/06 ,  A61K41/00 ,  C12N13/00 ,  G01N33/50

CPC classification number: C07K14/405 ,  A61K38/00 ,  A61K41/0023 ,  A61N5/062 ,  A61N2005/0661 ,  A61N2005/0662 ,  C12N13/00 ,  G01N33/48728 ,  G01N33/5041 ,  G01N33/5058

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

公开(公告)号：US20140324134A1

公开(公告)日：2014-10-30

申请号：US14357635

申请日：2012-11-12

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C12N13/00 ,  G01N33/487 ,  A61N5/06 ,  C07K14/405

CPC classification number: C07K14/405 ,  A61K38/00 ,  A61K41/0023 ,  A61N5/062 ,  A61N2005/0661 ,  A61N2005/0662 ,  C12N13/00 ,  G01N33/48728 ,  G01N33/5041 ,  G01N33/5058

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

Abstract translation: 本发明在一些方面涉及用于改变细胞活性和功能以及引入和使用光活化离子通道的组合物和方法。

公开(公告)号：US10711044B2

公开(公告)日：2020-07-14

申请号：US16570429

申请日：2019-09-13

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  C12N13/00 ,  A61N5/06 ,  G01N33/487 ,  A61K41/00 ,  G01N33/50 ,  A61K38/00

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

公开(公告)号：US10590181B2

公开(公告)日：2020-03-17

申请号：US14653040

申请日：2015-04-18

Applicant: Massachusetts Institute of Technology

Inventor： Edward S. Boyden ,  Yongku Peter Cho ,  Nathan C. Klapoetke ,  Amy S. Chuong ,  Fei Chen

IPC: C07K14/705 ,  C07K14/405 ,  G01N33/50 ,  A61K38/00

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.

公开(公告)号：US20200031883A1

公开(公告)日：2020-01-30

申请号：US16570429

申请日：2019-09-13

Applicant: Massachusetts Institute of Technology ,  The Governors of the University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  A61N5/06 ,  C12N13/00 ,  G01N33/487 ,  A61K41/00 ,  G01N33/50

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

公开(公告)号：US10472398B2

公开(公告)日：2019-11-12

申请号：US14357635

申请日：2012-11-12

Applicant: Massachusetts Institute of Technology ,  The Governors of The University of Alberta

Inventor： Nathan Klapoetke ,  Brian Yichiun Chow ,  Edward Boyden ,  Gane Ka-Shu Wong ,  Yongku Peter Cho

IPC: C07K14/405 ,  A61N5/06 ,  C12N13/00 ,  G01N33/487 ,  A61K41/00 ,  G01N33/50 ,  A61K38/00

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.