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公开(公告)号：US09474717B2
公开(公告)日：2016-10-25
申请号：US13844100
申请日：2013-03-15
申请人： Massachusetts Institute of Technology , The Children's Medical Center Corporation , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc.
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
CPC分类号： A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US20200054559A1
公开(公告)日：2020-02-20
申请号：US16544464
申请日：2019-08-19
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US09526702B2
公开(公告)日：2016-12-27
申请号：US13844258
申请日：2013-03-15
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
CPC分类号： A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供了在一些实施方案中能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，其包含至少一种免疫调节剂，并且任选地包含最后一个靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。
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公开(公告)号：US11547667B2
公开(公告)日：2023-01-10
申请号：US16544464
申请日：2019-08-19
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US09539210B2
公开(公告)日：2017-01-10
申请号：US13844382
申请日：2013-03-15
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
CPC分类号： A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供了在一些实施方案中能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，其包含至少一种免疫调节剂，并且任选地包含最后一个靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。
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公开(公告)号：US09308280B2
公开(公告)日：2016-04-12
申请号：US14046827
申请日：2013-10-04
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College
发明人： Jinjun Shi , Frank Alexis , Matteo Iannacone , Elliott Ashley Moseman , Pamela Basto , Robert S. Langer , Omid C. Farokhzad , Ulrich H. von Andrian , Elena Tonti
CPC分类号： A61K47/48869 , A61K39/00 , A61K47/6925 , A61K47/6935
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
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公开(公告)号：US20140037736A1
公开(公告)日：2014-02-06
申请号：US14046827
申请日：2013-10-04
申请人： Massachusetts Institute of Technology , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc.
发明人： Jinjun Shi , Frank Alexis , Matteo Iannacone , Elliott Ashley Moseman , Pamela Basto , Robert S. Langer , Omid C. Farokhzad , Ulrich H. von Andrian , Elena Tonti
IPC分类号： A61K47/48
CPC分类号： A61K47/48869 , A61K39/00 , A61K47/6925 , A61K47/6935
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫电泳表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。
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公开(公告)号：US10307487B2
公开(公告)日：2019-06-04
申请号：US14903964
申请日：2014-07-09
摘要： Disclosed herein are microvessel endothelial cell surface markers and methods, compositions, agents, and kits relating to those surface markers.
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公开(公告)号：US10206941B2
公开(公告)日：2019-02-19
申请号：US14903899
申请日：2014-07-09
IPC分类号： C12N15/11 , A61K31/713 , C07K14/47 , C12Q1/6881 , A61K47/54 , A61K47/69 , A61K48/00
摘要： Disclosed herein are genes which are differentially expressed in venule endothelial cells (V-ECs) compared to non-venule endothelial cells (NV-ECs) and methods and compositions relating to those genes. Also disclosed herein are methods of modulating the venuleness of an endothelial cell or microvessel, methods of modulating leukocyte trafficking, methods of modulating inflammation, methods of targeting agents to tissues based on their ability to bind to surface markers expressed in a microvessel (e.g., venules and non-venules), methods of identifying the venuleness of endothelial cells or microvessels, methods of identifying agents that modulate the venuleness of endothelial cells or microvessels, methods of identifying agents that target microvessels, methods for treating diseases associated with leukocyte trafficking, methods for treating inflammatory diseases, and compositions and kits for use in the methods.
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公开(公告)号：US20160354403A1
公开(公告)日：2016-12-08
申请号：US14903899
申请日：2014-07-09
IPC分类号： A61K31/713 , C12Q1/68 , A61K47/48
CPC分类号： A61K31/713 , A61K47/543 , A61K47/6929 , A61K48/00 , C07K14/47 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要： Disclosed herein are genes which are differentially expressed in venule endothelial cells (V-ECs) compared to non-venule endothelial cells (NV-ECs) and methods, compositions, kits, and agents relating to those genes.
摘要翻译： 本文公开了与非小静脉内皮细胞（NV-EC）相比的小静脉内皮细胞（V-EC）中差异表达的基因以及与这些基因相关的方法，组合物，试剂盒和试剂。
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