公开(公告)号：US20110172928A1

公开(公告)日：2011-07-14

申请号：US12999406

申请日：2009-06-16

申请人： Mathias Gehrmann ,  Udo Stropp ,  Karsten Weber ,  Christian Von Törne ,  Marcus Schmidt

发明人： Mathias Gehrmann ,  Udo Stropp ,  Karsten Weber ,  Christian Von Törne ,  Marcus Schmidt

IPC分类号： G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

摘要： The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.

摘要翻译： 本发明涉及用于预测肿瘤性疾病或癌症的结果的方法。 更具体地，本发明涉及通过在来自所述患者的生物样品中测定多种选自ACTG1，CA12，CALM2，CCND1，CHPT1，CLEC2B的多种基因的表达水平来预测乳腺癌的方法 ，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3，KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5 ，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF。

公开(公告)号：US20110166838A1

公开(公告)日：2011-07-07

申请号：US12999522

申请日：2009-06-16

申请人： Mathias Gehrmann ,  Ralf Kronenwett ,  Udo Stropp ,  Christian Von Törne ,  Karsten Weber

发明人： Mathias Gehrmann ,  Ralf Kronenwett ,  Udo Stropp ,  Christian Von Törne ,  Karsten Weber

IPC分类号： G06F7/60

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

摘要： The invention relates to methods for predicting an outcome of cancer in a patient suffering from cancer, said patient having been previously diagnosed as node positive and treated with cytotoxic chemotherapy, said method comprising determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CAl2, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF; ABCB1, ABCG2, ADAM15, AKR1C1, AKR1C3, AKT1, BANF1, BCL2, BIRC5, BRMS1, CASP10, CCNE2, CENPJ, CHPT1, EGFR, CTTN, ERBB3, ERBB4, FBLN1, FIP1L1, FLT1, FLT4, FNTA, GATA3, GSTP1, Herstatin, IGF1R, IGHM, KDR, KIT, CKRT5, SLC39A6, MAPK3, MAPT, MKI67, MMP7, MTA1, FRAP1, MUC1, MYC, NCOA3, NFIB, OLFM1, TP53, PCNA, PI3K, PPERLD1, RAB31, RAD54B, RAF1, SCUBE2, STAU, TINF2, TMSL8, VGLL1, TRA@, TUBA1, TUBB, TUBB2A.

摘要翻译： 本发明涉及用于预测患有癌症的患者的癌症结果的方法，所述患者先前被诊断为淋巴结阳性并用细胞毒性化疗治疗，所述方法包括在来自所述患者的生物样品中确定多个表达水平 选自ACTG1，CA2，CALM2，CCND1，CHPT1，CLEC2B，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3， KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF; ABCB1，ABCG2，ADAM15，AKR1C1，AKR1C3，AKT1，BANF1，BCL2，BIRC5，BRMS1，CASP10，CCNE2，CENPJ，CHPT1，EGFR，CTTN，ERBB3，ERBB4，FBLN1，FIP1L1，FLT1，FLT4，FNTA，GATA3，GSTP1， Herbatin，IGF1R，IGHM，KDR，KIT，CKRT5，SLC39A6，MAPK3，MAPT，MKI67，MMP7，MTA1，FRAP1，MUC1，MYC，NCOA3，NFIB，OLFM1，TP53，PCNA，PI3K，PPERLD1，RAB31，RAD54B，RAF1， SCUBE2，STAU，TINF2，TMSL8，VGLL1，TRA @，TUBA1，TUBB，TUBB2A。

公开(公告)号：US20120053842A9

公开(公告)日：2012-03-01

申请号：US12999406

申请日：2009-06-16

申请人： Mathias Gehrmann ,  Udo Stropp ,  Karsten Weber ,  Christian Von T+e,uml o+ee ne ,  Marcus Schmidt

发明人： Mathias Gehrmann ,  Udo Stropp ,  Karsten Weber ,  Christian Von T+e,uml o+ee ne ,  Marcus Schmidt

IPC分类号： G06F19/00

CPC分类号： G06F19/24 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G06F19/18 ,  G06F19/20

摘要： The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.

摘要翻译： 本发明涉及用于预测肿瘤性疾病或癌症的结果的方法。 更具体地，本发明涉及通过在来自所述患者的生物样品中测定多种选自ACTG1，CA12，CALM2，CCND1，CHPT1，CLEC2B的多种基因的表达水平来预测乳腺癌的方法 ，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3，KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5 ，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF。

公开(公告)号：US20130065786A1

公开(公告)日：2013-03-14

申请号：US13638360

申请日：2011-03-29

申请人： Mareike Dartmann ,  Inke Sabine Feder ,  Mathias Gehrmann ,  Guido Hennig ,  Karsten Weber ,  Christian Von Törne ,  Ralf Kronenwett ,  Christoph Petry

发明人： Mareike Dartmann ,  Inke Sabine Feder ,  Mathias Gehrmann ,  Guido Hennig ,  Karsten Weber ,  Christian Von Törne ,  Ralf Kronenwett ,  Christoph Petry

IPC分类号： C40B30/04 ,  C40B40/06 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer, said method comprising: (a) determining in a tumor sample from said patient the RNA expression levels of at least 2 of the following 9 genes: UBE2C, BIRC5, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP (b) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is indicative of a prognosis of said patient; and kits and systems for performing said method.

摘要翻译： 本发明涉及用于乳腺癌疾病预后的方法，试剂盒和系统，所述方法包括：（a）在所述患者的肿瘤样品中测定以下9个基因中至少2个的RNA表达水平： UBE2C，BIRC5，RACGAP1，DHCR7，STC2，AZGP1，RBBP8，IL6ST和MGP（b）在数学上组合所述组的基因的表达水平值，其在肿瘤样品中测定以产生组合评分，其中所述组合 评分表示所述患者的预后; 以及用于执行所述方法的套件和系统。

公开(公告)号：US20140228241A1

公开(公告)日：2014-08-14

申请号：US14235168

申请日：2012-07-30

申请人： Mathias Gehrmann ,  Karsten Weber ,  Ralf Kronenwett ,  Christoph Petry ,  Jan Christoph Brase

发明人： Mathias Gehrmann ,  Karsten Weber ,  Ralf Kronenwett ,  Christoph Petry ,  Jan Christoph Brase

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A method for predicting a response to and/or benefit of chemotherapy, including neoadjuvant chemotherapy, in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprising the steps of: (a) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP, indicative of a response to chemotherapy for a tumor, or (b) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP; indicative of a response to chemotherapy for a tumor (c) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is predicting said response and/or benefit of chemotherapy.

摘要翻译： 一种在患有或有发生复发性肿瘤疾病，特别是乳腺癌风险的患者中预测化疗（包括新辅助化疗）的反应和/或益处的方法，所述方法包括以下步骤：（a）在 来自所述患者的肿瘤样品包括以下8个基因：UBE2C，RACGAP1，DHCR7，STC2，AZGP1，RBBP8，IL6ST和MGP的RNA表达水平，其指示对肿瘤的化学疗法的反应，或（b）在肿瘤中测定 来自所述患者的样品来自以下8个基因的RNA表达水平：UBE2C，BIRC5，DHCR7，STC2，AZGP1，RBBP8，IL6ST和MGP; 指示对肿瘤的化学疗法的反应（c）在数学上组合所述组的基因的表达水平值，所述基因在肿瘤样品中测定以产生组合评分，其中所述组合评分预测所述应答和/或益处 的化疗。

公开(公告)号：US20100001444A1

公开(公告)日：2010-01-07

申请号：US12374583

申请日：2007-08-07

申请人： Karsten Weber

发明人： Karsten Weber

IPC分类号： F16F9/05

CPC分类号： B60G11/27 ,  B60G7/04 ,  B60G2202/152 ,  B60G2204/45 ,  B60G2204/4502 ,  F16F9/052 ,  F16F9/057

摘要： An air spring for a vehicle comprises an air bellows that includes an axle-side region and a superstructure-side region movable with respect to one other between a first, adjacent position and a second, spaced-apart position, and a plunger which is arranged on the axle-side region of the air bellows. The air spring further comprising a fastening section adapted to fasten the superstructure-side region of the air bellows to a support element of the vehicle, and a displacement element which is arranged on the fastening section of the air bellows, wherein the displacement element fills at least a substantial portion of the space between the plunger and the fastening section in the first position of the air bellows.

摘要翻译： 一种用于车辆的空气弹簧包括空气波纹管，其包括轴侧区域和在第一相邻位置和第二间隔位置之间可相对于彼此移动的上部结构侧区域，以及布置成 在空气波纹管的轴侧区域。 空气弹簧还包括紧固部分，其适于将空气波纹管的上部结构侧区域紧固到车辆的支撑元件;以及位移元件，其布置在空气波纹管的紧固部分上，其中位移元件填充在 在空气波纹管的第一位置的柱塞和紧固部分之间的空间的至少大部分。

公开(公告)号：US20130189702A1

公开(公告)日：2013-07-25

申请号：US13642358

申请日：2011-04-07

申请人： Gabriela Altmann ,  Mareike Dartmann ,  Inke Sabine Feder ,  Tanja Ropers ,  Claudia Roth ,  Karsten Weber

发明人： Gabriela Altmann ,  Mareike Dartmann ,  Inke Sabine Feder ,  Tanja Ropers ,  Claudia Roth ,  Karsten Weber

IPC分类号： G06F19/10

CPC分类号： G16B99/00 ,  C12Q1/6851 ,  G16B40/00 ,  C12Q2537/165

摘要： The invention is in the field of analytical technology and relates to an improved procedure for determining the concentration or activity of an analyte in a sample. Specifically the invention provides an automated algorithm for the quality control of (RT-)qPCR reactions. Plotting the fluorescence intensity of a reporter dye divided by the fluorescence intensity of a passive reference dye against the cycle number leads to a so-called sigmoid function which is characterized by a background phase, an exponential growth phase and a plateau phase. Since the fluorescence intensity as a function of cycles relates to the initial number of template molecules in the sample, qPCR curves can be used to quantify the amount of RNA or DNA fragments in the sample by determination of a so-called Cq value.

摘要翻译： 本发明涉及分析技术领域，涉及用于测定样品中分析物的浓度或活性的改进方法。 具体地，本发明提供了用于（RT-）qPCR反应的质量控制的自动化算法。 报道染料的荧光强度除以被动参比染料的荧光强度与循环次数的关系，得出所谓的乙状结晶功能，其特征在于背景相，指数生长期和平台期。 由于作为循环的函数的荧光强度与样品中模板分子的初始数量有关，因此qPCR曲线可用于通过确定所谓的Cq值来定量样品中RNA或DNA片段的量。

公开(公告)号：US20120018565A1

公开(公告)日：2012-01-26

申请号：US13143820

申请日：2009-10-23

申请人： Karsten Weber

发明人： Karsten Weber

IPC分类号： B65H75/24

CPC分类号： B65H75/243

摘要： The present invention relates to an expandable shaft (1) for insertion into a core, the expandable shaft have a longitudinal extension and comprising: a profile (4), which extends in the longitudinal direction of the shaft, the profile comprising a plurality of longitudinal grooves; inflatable and expandable chambers which are adapted to be arranged in the grooves; gripping means (3) which are arranged in connection to the expandable chambers, the gripping means being adapted to radial movement between a first position and a second position in view of an expansion of the inflatable and expandable chambers so that the gripping means (3) are movable in a radial direction between a first position and a second position depending on an expansion of the expandable chambers wherein an outer cylindrical tube is arranged outside the profile (4), the outer cylindrical tube comprising a plurality of openings, and wherein the gripping means (3) are aligned with the openings of the tube so that the gripping means can project through and beyond the tube in a radial direction of the shaft during the expansion of the expandable chambers.

摘要翻译： 本发明涉及一种用于插入到芯中的可膨胀轴（1），该可膨胀轴具有一纵向延伸部分，并包括：一个在轴的纵向延伸的型材（4），该型材包括多个纵向 凹槽 适于布置在凹槽中的充气和可膨胀室; 夹持装置（3），其布置成与可膨胀腔室相连接，所述夹持装置适于在可膨胀和可膨胀腔室的膨胀的情况下考虑到第一位置和第二位置之间的径向移动，使得夹持装置（3） 可根据可膨胀室的膨胀在第一位置和第二位置之间沿径向方向移动，其中外圆柱形管布置在型材（4）的外侧，外圆柱形管包括多个开口，并且其中夹紧 装置（3）与管的开口对准，使得夹持装置可以在可膨胀室的膨胀期间沿着轴的径向突出并超过管。

公开(公告)号：US07634896B2

公开(公告)日：2009-12-22

申请号：US11949926

申请日：2007-12-04

申请人： Steven Multer ,  Karsten Weber

发明人： Steven Multer ,  Karsten Weber

IPC分类号： B65B1/04 ,  B65B3/04

CPC分类号： B65G69/181 ,  B65B1/28 ,  B65B69/0008 ,  B65B69/0075

摘要： A liner emptying device and a liner filling device as well as methods using them for contamination-free filling and emptying of a liner. This contamination-free filling and emptying prevents any danger to the health of the people working with the packaged substances. Both the liner emptying device and the liner filling device are connected to the liner via a fastening device and the residual films sealing off the device can be removed via an access port, whereby the liner can be filled or emptied without contaminating the surroundings.

摘要翻译： 衬管排空装置和衬管填充装置以及使用它们的方法用于无衬里的无污染填充和排空。 这种无污染的填充和排空可以防止使用包装物质的人的健康受到任何危害。 衬管排空装置和衬垫填充装置都通过紧固装置连接到衬套，并且可以通过进入口移除密封装置的残留膜，由此衬垫可以被填充或排空而不污染周围环境。

公开(公告)号：US20070098904A1

公开(公告)日：2007-05-03

申请号：US11440796

申请日：2006-05-25

申请人： Helmut Aschner ,  Patrick Schmid ,  Thomas Theiler ,  Ottmar Heudorfer ,  Karsten Weber ,  Conor O'Carroll

发明人： Helmut Aschner ,  Patrick Schmid ,  Thomas Theiler ,  Ottmar Heudorfer ,  Karsten Weber ,  Conor O'Carroll

IPC分类号： B05D3/02 ,  H01L21/00

CPC分类号： H01L21/67115 ,  F27B5/04 ,  F27B17/0025 ,  F27D5/0037 ,  H01L21/324 ,  H01L21/6719 ,  H01L21/68792

摘要： A device and a method for reducing particle exposure to substrates during thermal treatment are disclosed. Semiconductor wafers may be rotated on a device within a process chamber divided into two partial chambers such that a first partial chamber contains the substrate to be thermally treated and a second partial chamber contains at least parts of the rotation device. Between the partial chambers, a flow of gas is set such that gas from the second partial chamber is substantially prevented from passing into the first partial chamber. In this way, particles which are produced by rotation abrasion in the second partial chamber are largely prevented from passing onto the substrate to be thermally treated. This device and this method are particularly advantageous if the rotation is realized by means of a gas drive, wherein the gas used for the rotation can be introduced directly into the second partial chamber.

摘要翻译： 公开了一种用于在热处理期间减少颗粒暴露于基板的装置和方法。 半导体晶片可以在分成两个部分室的处理室内的装置上旋转，使得第一部分室包含待热处理的基板，并且第二部分室至少包含旋转装置的一部分。 在部分室之间，设置气流，使得基本上防止来自第二部分室的气体进入第一部分室。 以这种方式，通过第二部分室中的旋转磨损产生的颗粒被大大地防止被传递到待热处理的基板上。 如果通过气体驱动实现旋转，则该装置和该方法是特别有利的，其中用于旋转的气体可以直接引入第二部分室。