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公开(公告)号：US07118909B2
公开(公告)日：2006-10-10
申请号：US10146683
申请日：2002-05-15
CPC分类号： C12M25/04
摘要： An apparatus to facilitate precise and efficient evaluation of biomaterials using direct contact cell culture techniques. The apparatus positions the biomaterial and creates the potential to form a fluid-tight seal between the biomaterial and the apparatus, at which point the biomaterial is exposed to cells and/or media. An assay method based on the apparatus is claimed.
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公开(公告)号：US08293531B1
公开(公告)日：2012-10-23
申请号：US12201297
申请日：2008-08-29
申请人： Karen J. L. Burg , Chih-Chao Yang
发明人： Karen J. L. Burg , Chih-Chao Yang
IPC分类号： C12N5/02
CPC分类号： C12N5/0062 , C12N2533/30 , C12N2533/74
摘要： Disclosed are three-dimensional (3D) systems as may be utilized for ex vivo tissue or cell growth and development. A system generally includes a base material and at least one wicking fiber embedded therein through which a liquid can be spontaneously drawn by capillary action. Wicking fibers can define a plurality of colinear channels along the exterior surface of the axial length of the fiber. Wicking fibers can be present in disclosed systems as individual fibers or in bundles. Disclosed systems can be useful in various scientific studies, including, but not limited to, drug discovery, vaccine development, cell biology studies, and biomaterial development.
摘要翻译： 公开了可用于离体组织或细胞生长和发育的三维（3D）系统。 系统通常包括基材和嵌入其中的至少一个芯吸纤维，液体可以通过毛细管作用自发地被吸引。 芯吸纤维可以沿着纤维的轴向长度的外表面限定多个共线通道。 在所公开的系统中，芯吸纤维可以作为单独的纤维或捆束存在。 公开的系统可用于各种科学研究，包括但不限于药物发现，疫苗开发，细胞生物学研究和生物材料开发。
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公开(公告)号：US06206930B1
公开(公告)日：2001-03-27
申请号：US09131470
申请日：1998-08-10
IPC分类号： A61F224
CPC分类号： A61F2/0063 , A61F2/02
摘要： The invention relates to an absorbable implantable tissue expander device that can be used in surgeries as a gradually diminishing space filler. The absorbable tissue expander has a fluid-tight or semipermeable envelope having a bio-absorbable biocompatible shell defining a chamber. The envelope is inflatable upon infusion of a fluid into the chamber and deflatable upon removal of the fluid from the chamber. The tissue expander also enables the controlled inflation and deflation of the envelope after the device is implanted in a tissue.
摘要翻译： 本发明涉及一种可吸收植入式组织扩张装置，其可用作手术中逐渐减小的空间填充物。 可吸收组织扩张器具有流体密封或半透膜封套，其具有限定腔室的生物可吸收生物相容性外壳。 当将流体输入到腔室中时，该信封可充气，并且在从腔室移除流体时可以充气。 在将装置植入组织中之后，组织扩张器还能够使包膜受到控制的充气和放气。
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公开(公告)号：US06991652B2
公开(公告)日：2006-01-31
申请号：US09879360
申请日：2001-06-12
申请人： Karen J. L. Burg
发明人： Karen J. L. Burg
IPC分类号： A61F2/12
CPC分类号： A61L27/50 , A61F2/0059 , A61F2/28 , A61F2/30756 , A61F2/3099 , A61F2/442 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00365 , A61F2310/00982 , A61L27/48 , A61L27/52 , A61L27/56
摘要： The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered to an area of interest in a living subject. The biodegradable construct provides an ideal surface for cell or cell extract attachment, while the gel matrix or viscous fluid acts as both a carrier material and a separator for maintaining the space between the constructs as well as the structural integrity of the developing issue.
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公开(公告)号：US06666893B2
公开(公告)日：2003-12-23
申请号：US09819847
申请日：2001-03-28
IPC分类号： A61F202
CPC分类号： A61F2/0063 , A61F2/02
摘要： A method of reconstructing tissue is provided. The method includes implanting an absorbable tissue expander having a fluid-tight or semipermeable envelope and having a bio-absorbable biocompatible shell defining a chamber. The envelope is inflatable upon infusion of a fluid into the chamber and deflatable upon removal of the fluid from the chamber. The tissue expander also has an injection port for the controlled inflation and deflation of the envelope after the device is implanted in a tissue. The method also may include a plurality of envelopes.
摘要翻译： 提供了一种重建组织的方法。 该方法包括植入具有流体密封或半透性封套的可吸收组织扩张器，并具有限定腔室的生物可吸收生物相容性外壳。 当将流体输入到腔室中时，该信封可充气，并且在从腔室移除流体时可以充气。 组织扩张器还具有注射端口，用于在将装置植入组织后用于受控的包膜放气和放气。 该方法还可以包括多个信封。
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公开(公告)号：US08865460B2
公开(公告)日：2014-10-21
申请号：US11996610
申请日：2006-08-11
申请人： David E. Orr , Karen J. L. Burg
发明人： David E. Orr , Karen J. L. Burg
摘要： Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.
摘要翻译： 公开了多室细胞共培养系统。 该系统可用于在动态三维体外环境中促进分离细胞的生长和发育。 系统的细胞室（10）可以与包含不同类型的细胞的相邻室进行生物化学连通，但不同的细胞类型彼此保持物理分离。 此外，每个电池室的局部环境可以独立控制。 例如，通过单个电池室的流体流动特性可以被独立地控制并维持在系统的每个分开的室中。
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公开(公告)号：US08475531B1
公开(公告)日：2013-07-02
申请号：US12763515
申请日：2010-04-20
申请人： Scott A. Maxson , Karen J. L. Burg
发明人： Scott A. Maxson , Karen J. L. Burg
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/30772 , A61F2002/30878 , A61L27/18 , A61L27/20 , A61L27/3834 , A61L27/46 , A61L27/52 , A61L27/56 , A61L2430/24 , C08L5/12 , C08L67/04 , C08L75/04
摘要： Disclosed are osteochondral constructs that can be utilized to encourage both bone and articular cartilage tissue repair in synovial joints. Disclosed constructs are composites including a hydrogel portion for implant in a cartilage defect site and an adjacent portion for implant in a bone defect site. The portion to be implanted in a bone defect site can include a polymeric/ceramic composite material. Disclosed constructs also include a polymeric anchor that can secure the construct at the desired site. Disclosed constructs can also include capillary channeled fibers within the bone portion of the construct that can provide improved nutrient flow to and waste flow from cells growing and developing on and in the construct.
摘要翻译： 公开了可用于鼓励关节软骨关节软骨组织修复的骨软骨构建体。 公开的构建体是包括用于植入在软骨缺损部位中的水凝胶部分和用于植入在骨缺损部位中的相邻部分的复合材料。 植入骨缺损部位的部分可以包括聚合物/陶瓷复合材料。 所公开的构建体还包括能够将构建体固定在所需位点的聚合物锚。 所公开的构建体还可以包括在构建体的骨部分内的毛细管通道纤维，其可以提供改善的营养物流和来自在构建体上和在构建体中生长和发育的细胞的流动。
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