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公开(公告)号：US20050284473A1
公开(公告)日：2005-12-29
申请号：US11130970
申请日：2005-05-17
CPC分类号： A61M15/0028 , A61M15/0008 , A61M15/0043 , A61M15/0086 , A61M2202/064 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2206/16
摘要： A unit dose dry powder inhaler includes a chamber housing containing a powder dispersion chamber. A chamber tube extends from the dispersion chamber into the mouthpiece. A cover or cup is rotatably attached to the chamber housing. A dose of a dry powder is contained at a powder location in the chamber housing. An air passageway leading from the powder location to the dispersion chamber is closed off by the cover. When the cover is rotated to an open position, the air passageway is opened. The user inhales on the mouthpiece drawing air through the powder location, the air passageway, the dispersion chamber and the chamber tube, through the mouthpiece and into the users lungs. The unit dose of dry powder is stored directly in, or is part of, the inhaler.
摘要翻译： 单位剂量干粉吸入器包括容纳粉末分散室的室壳体。 室管从分散室延伸到接口管中。 盖或杯可旋转地附接到腔室壳体。 干燥粉末的剂量被容纳在腔室中的粉末位置。 从粉末位置到分散室的空气通道由盖封闭。 当盖旋转到打开位置时，空气通道打开。 使用者吸入吹口，通过粉末位置，空气通道，分散室和室管抽吸空气，通过吸嘴并进入使用者的肺部。 干粉的单位剂量直接储存在吸入器中，或者是吸入器的一部分。
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公开(公告)号：US20050263153A1
公开(公告)日：2005-12-01
申请号：US11130959
申请日：2005-05-17
CPC分类号： A61M15/0028 , A61M15/0008 , A61M15/0031 , A61M15/0086 , A61M2202/064 , A61M2205/583 , A61M2205/6045
摘要： A unit dose dry powder inhaler has a dose unit within an inhaler housing. As the dose unit is pushed into the inhaler housing, a container on the dose unit is opened, releasing a pharmaceutical powder into the housing. The user inhales on a mouthpiece, drawing the powder and air into a dispersion chamber. The powder disperses in air, and the powder/air mixture is inhaled. The inhaler is inexpensive, compact, and simple to use.
摘要翻译： 单位剂量干粉吸入器在吸入器外壳内具有剂量单位。 当剂量单元被推入吸入器壳体中时，打开剂量单元上的容器，将药物粉末释放到壳体中。 使用者吸入吹嘴，将粉末和空气吸入分散室。 粉末分散在空气中，并且粉末/空气混合物被吸入。 吸入器便宜，紧凑，使用简单。
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公开(公告)号：US07069929B2
公开(公告)日：2006-07-04
申请号：US10099592
申请日：2002-03-15
申请人： Matthew Young , Stuart Kay , Neil Harrison , James Welsh , Michael Ligotke
发明人： Matthew Young , Stuart Kay , Neil Harrison , James Welsh , Michael Ligotke
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0026 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0071 , A61M15/0075 , A61M15/02 , A61M2202/064 , A61M2205/583 , A61M2205/6045 , A61M2206/16
摘要： A dry powder inhaler includes an actuator pivotably mounted on a base. Movement of the actuator from a first position to a second position drives the a dobber to open a blister. A dispersion engine sub-assembly has a blister hood positioned over a blister opening position. A powder pathway connects from the blister hood into a powder dispersion engine. Upon inhalation, air flow draws powder up and out of an opened blister, into the blister hood and to the powder dispersion engine. Movement of the actuator causes the dobber to shear open a blister and also to press the blister hood down over the blister. This increases air flows up and around the open blister, carrying the pharmaceutical powder up and out of the blister and into the dispersion engine.
摘要翻译： 干粉吸入器包括可枢转地安装在基座上的致动器。 致动器从第一位置到第二位置的移动驱动一个阻挡器以打开水泡。 分散发动机子组件具有位于泡罩打开位置上方的泡罩罩。 粉末通道从泡罩罩连接成粉末分散发动机。 吸入后，空气流将粉末从开放的水泡中抽出，进入泡罩罩和粉末分散发动机。 执行机构的运动导致踩踏器打开水泡并且还将泡罩罩向下压过水泡。 这增加了空气在开放的水泡周围流动，并将药剂粉末从泡罩中提出并进入分散发动机。
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公开(公告)号：US20090084380A1
公开(公告)日：2009-04-02
申请号：US12328657
申请日：2008-12-04
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US07958890B2
公开(公告)日：2011-06-14
申请号：US12328657
申请日：2008-12-04
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06715486B2
公开(公告)日：2004-04-06
申请号：US09773261
申请日：2001-01-31
IPC分类号： A61M1600
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US20060005833A1
公开(公告)日：2006-01-12
申请号：US11224406
申请日：2005-09-12
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06427688B1
公开(公告)日：2002-08-06
申请号：US09495494
申请日：2000-02-01
申请人： Michael Ligotke , Andrew W. Gieschen , Robert F. Eisele , Thomas R. Jackson , Jeffrey Chen , Bernard Greenspan , Clyde Witham , Gary Ward
发明人： Michael Ligotke , Andrew W. Gieschen , Robert F. Eisele , Thomas R. Jackson , Jeffrey Chen , Bernard Greenspan , Clyde Witham , Gary Ward
IPC分类号： A61M1500
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06971384B2
公开(公告)日：2005-12-06
申请号：US10782449
申请日：2004-02-19
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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