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    Mouth Rinse Emulsions
    6.
    发明申请
    Mouth Rinse Emulsions 审中-公开
    口腔冲洗乳液

    公开(公告)号：US20130344120A1

    公开(公告)日：2013-12-26

    申请号：US13529064

    申请日：2012-06-21

    申请人： Douglas Craig Scott ,  Niranjan Ramji ,  Bruce Ernest Tepper

    发明人： Douglas Craig Scott ,  Niranjan Ramji ,  Bruce Ernest Tepper

    IPC分类号： A61K8/92 ,  A61K8/06 ,  C12Q1/18 ,  A61Q11/00

    CPC分类号： A61Q17/005 ,  A61K8/062 ,  A61K8/416 ,  A61Q11/00 ,  C12Q1/18

    摘要： Disclosed are oral care mouth rinse compositions formulated as stable oil-in-water emulsions comprising: (a) at least about 0.025% by weight of a quaternary ammonium antimicrobial agent, (b) at least about 0.05% by weight of an essentially water-insoluble volatile oil, and (c) at least about 50% by weight water, wherein the emulsion comprises oil droplets having an average mean particle size of about 350 nm or less. Examples of quaternary ammonium antimicrobial agent include cetylpyridinium chloride (CPC), tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide.

    摘要翻译： 公开了配制为稳定的水包油乳液的口腔护理口腔漂洗组合物，其包含：（a）至少约0.025重量％的季铵抗微生物剂，（b）至少约0.05重量％ 不溶性挥发油，和（c）至少约50重量％的水，其中所述乳液包含平均粒度为约350nm或更小的油滴。 季铵抗菌剂的实例包括氯化十六烷基吡啶（CPC），氯化十四烷基吡啶，氯化N-十四烷基-4-乙基吡啶鎓或溴化三苯胺。

    Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge
    9.
    发明授权
    Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge 失效
    增强和/或延长主要挑战对具有次要挑战的响应系统的影响的方法

    公开(公告)号：US06756032B1

    公开(公告)日：2004-06-29

    申请号：US09614669

    申请日：2000-07-12

    申请人： Bruce Ernest Tepper ,  Susan Baldwin ,  Scott Edward Osborne ,  Mauricio Odio

    发明人： Bruce Ernest Tepper ,  Susan Baldwin ,  Scott Edward Osborne ,  Mauricio Odio

    IPC分类号： A61B1000

    CPC分类号： A61K49/0006 ,  Y10S530/859

    摘要： The present invention relates to a method comprising subjecting a test site of a responsive system to a primary challenge; subjecting the same test site to a secondary challenge, wherein the secondary challenge is designed to enhance and/or prolong a response of the responsive system to the primary challenge, without confounding the response nor altering the mechanism by which the primary challenge elicits a response from the responsive system; and assessing the response subsequent to the secondary challenge. The methods claimed herein also preferably comprise the additional step(s) of subjecting test site(s) to one or more pre-challenge intervention(s) and/or post-challenge intervention(s) and/or concurrent-challenge intervention(s). The methods of the present invention are also useful in a study design, also claimed herein, wherein the study comprises the steps of the method outlined above in addition to comprising the steps of creating one or more controls selected from the group consisting of negative controls, primary controls, secondary controls, positive controls, and mixtures thereof. The use of the novel methods described herein often significantly shorten the duration of and/or number of subjects needed for studies aimed at understanding the etiology of a disease and/or the ability of a intervention or challenge to prevent, cure, heal, and/or reduce and/or induce damage or injury to a responsive system.

    摘要翻译： 本发明涉及一种方法，包括使响应系统的测试部位进行初步挑战; 对相同的测试场所进行二次挑战，其中次要挑战被设计为增强和/或延长响应系统对主要挑战的响应，而不会混淆响应，也不改变主要挑战引起响应的机制 响应系统; 并评估二次挑战之后的反应。 本文要求保护的方法还优选地包括使试验部位进行一次或多次攻击前干预和/或攻击后干预和/或并发挑战干预的附加步骤（s） ）。 本发明的方法还可用于本文还要求保护的研究设计中，其中所述研究包括上述方法的步骤，此外还包括以下步骤：产生选自以下的一种或多种对照：阴性对照， 初级对照，二级对照，阳性对照及其混合物。 使用本文所述的新颖方法通常显着地缩短旨在了解疾病病因的研究所需的受试者的持续时间和/或数量和/或干预或挑战的能力以预防，治愈，愈合和/ 或减少和/或引起对响应系统的损害或伤害。